Human LIMPII/SR-B2 Antibody Summary
Arg27-Thr432
Accession # Q14108
Applications
Human LIMPII/SR-B2 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: LIMPII/SR-B2
LIMPII (Lysosomal Integral Membrane Protein II), also known as LPG85 (85 kDa lysosomal membrane sialoglycoprotein) and as CD36 antigen-like 2 (CD36L2), is a major lysosomal membrane protein. It belongs to the scavenger receptor class B subfamily and is designated member 2 (SR-B2). Other mammalian members of this family include SR-B1 (alternatively known as Cla-1 and CD36L1), and SR-B3 (CD36) (1 - 3). SR-B/CD36 family members are type III integral membrane proteins with an N- as well as a C-terminal cytoplasmic tail, and a large extracellular (or lumenal in the case of LIMPII) loop containing similarly spaced cysteine residues and multiple glycosylation sites. The C-terminal cytoplasmic tail has a di-leucine-based motif that mediates effective lysosomal targeting. LIMPII is widely expressed on all tissues and cell types so far examined. It is also expressed on the surface of activated platelets. LIMPII binds thrombospondin-1, but the biological significance of this interaction is not known. LIMPII-thrombospondin interaction may contribute to the pro-adhesive changes of activated platelets during coagulation, and inflammation (1). Overexpression of LIMPII causes an enlargement of early endosomes and late endosomes, suggesting that LIMPII may play a role in lysosome/endosome biogenesis (4). Mice deficient in LIMPII are impaired in membrane transport processes, resulting in ureteric pelvic junction obstruction, deafness and peripheral neuropathy (5).
- Crombie, R. and R. Silverstein (1998) J. Biol. Chem. 273:4855.
- Febbraio, M. et al. (2001) J. Clin. Invest. 108:785.
- Eskelinen, E-L. et al. (2003) Trends in Cell Biology 13:137.
- Kuronita, T. et al. (2002) J. Cell Sci. 115:4117.
- Gamp, A-C. et al. (2003) Human Molecular Genetics 12:631.
Product Datasheets
Citations for Human LIMPII/SR-B2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Human SCARB2 Acts as a Cellular Associator for Helping Coxsackieviruses A10 Infection
Authors: SL Yu, NH Chung, YC Lin, YA Liao, YC Chen, YH Chow
Viruses, 2023-04-08;15(4):.
Species: Human
Sample Types: Cell Lysates
Applications: Immunoprecipitation -
Human SCARB2 Acts as a Cellular Associator for Helping Coxsackieviruses A10 Infection
Authors: SL Yu, NH Chung, YC Lin, YA Liao, YC Chen, YH Chow
Viruses, 2023;15(4):.
Species: Human
Sample Types: Cell Lysates
Applications: Immunoprecipitation -
Cross-linking of the endolysosomal system reveals potential flotillin structures and cargo
Authors: J Singh, H Elhabashy, P Muthukotti, M Stepath, M Eisenacher, O Kohlbacher, V Gieselmann, D Winter
Nature Communications, 2022-10-20;13(1):6212.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Proteomics of Primary Uveal Melanoma: Insights into Metastasis and Protein Biomarkers
Authors: GF Jang, JS Crabb, B Hu, B Willard, H Kalirai, AD Singh, SE Coupland, JW Crabb
Cancers, 2021-07-14;13(14):.
Species: Human
Sample Types: Tissue Homogenates
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Involvement of VCP/UFD1/Nucleolin in the viral entry of Enterovirus A species
Authors: J Yan, M Wang, M Wang, Y Dun, L Zhu, Z Yi, S Zhang
Virus Res., 2020-04-11;283(0):197974.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Heparan sulfate attachment receptor is a major selection factor for attenuated enterovirus 71 mutants during cell culture adaptation
Authors: K Kobayashi, K Mizuta, S Koike
PLoS Pathog., 2020-03-18;16(3):e1008428.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Fibronectin facilitates EV71 infection by mediating its entry
Authors: QQ He, S Ren, ZC Xia, ZK Cheng, NF Peng, Y Zhu
J. Virol., 2018-04-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
The binding of a monoclonal antibody to the apical region of SCARB2 blocks EV71 infection
Authors: X Zhang, P Yang, N Wang, J Zhang, J Li, H Guo, X Yin, Z Rao, X Wang, L Zhang
Protein Cell, 2017-04-26;0(0):.
Species: Human, Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Transcriptome analysis reveals dynamic changes in coxsackievirus A16 infected HEK 293T cells
Authors: J Jin, R Li, C Jiang, R Zhang, X Ge, F Liang, X Sheng, W Dai, M Chen, J Wu, J Xiao, W Su
BMC Genomics, 2017-01-25;18(0):933.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Amphotericin B Inhibits Enterovirus 71 Replication by Impeding Viral Entry
Sci Rep, 2016-09-09;6(0):33150.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
The role of Misshapen NCK-related kinase (MINK), a novel Ste20 family kinase, in the IRES-mediated protein translation of human enterovirus 71.
Authors: Leong, Shi Yun, Ong, Bryan Ki, Chu, Justin J
PLoS Pathog, 2015-03-06;11(3):e1004686.
Species: Human
Sample Types: Whole Cells
Applications: Functional Assay -
Scavenger receptor B2 is a cellular receptor for enterovirus 71.
Authors: Yamayoshi S, Yamashita Y, Li J, Hanagata N, Minowa T, Takemura T, Koike S
Nat. Med., 2009-06-21;15(7):798-801.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry, Neutralization
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