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Learn MoreMicroglia Steady-State Markers
This interactive graphic lists some of the markers most commonly used to detect steady-state microglia including CD11b and Ionized Calcium-Binding Adapter Molecule 1 (Iba1). Clicking on a molecule will take you to the R&D Systems product selection for researching that molecule. Clicking on a molecule that is designated by (novusbio.com) will take you to the Novus Biologicals’ website and their antibody offerings for that protein. Additionally, use the buttons below to see markers associated with different microglia phenotypes.
Factors
Factors
Overview
Under nonpathological conditions, microglia function to maintain homeostasis of the surrounding nervous tissue. Steady-state, or ramified, microglia possess an extensive arborization of thin processes that repeatedly extend and retract into the surrounding tissue so to monitor the local microenvironment. Upon detection of injury or an invading pathogen, microglia become activated and initiate an immune response resulting in the production of inflammatory molecules, secretion of trophic factors, and phagocytizing cellular debris. Ramified microglia have also been shown to be important for neuronal circuit remodeling. They promote synapse formation and elimination in both the developing and mature brain, and regulate the maturation and plasticity of previously established synaptic connections.
