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TL 13-112

Catalog #: 6745
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6745/5
TL 13-112 | CAS No. 2229037-19-6 | Active Degraders
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Description: Selective ALK Degrader (PROTAC®)

Chemical Name: N-[2-[2-[2-[4-[4-[[5-Chloro-4-[[2-[(1-methylethyl)sulfonyl]phenyl]amino]-2-pyrimidinyl]amino]-2-methyl-5-(1-methylethoxy)phenyl]-1-piperidinyl]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]acetamide

Purity: ≥98%

Product Details
Citations (3)
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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

TL 13-112 is a selective anaplastic lymphoma kinase (ALK) Degrader (PROTAC®) (DC50 values are 10 and 40 nM in H3122 and Karpas 299 cells, respectively). Comprises the cereblon E3 ligase ligand Pomalidomide (Cat. No. 6302) conjugated to an ALK inhibitor. Inhibits proliferation of ALK-positive cancer cell lines. Maximum degradation exhibited at 16 h.

Negative control TL 13-110 (Cat. No. 6746), and ALK antibody validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF4210.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data

M.Wt:
1002.57
Formula:
C49H60ClN9O10S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2229037-19-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

Background References

  1. Chemically induced degradation of anaplastic lymphoma kinase (ALK).
    Powell et al.
    J.Med.Chem., 2019;61:4249

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Citations for TL 13-112

The citations listed below are publications that use Tocris products. Selected citations for TL 13-112 include:

3 Citations: Showing 1 - 3

  1. Engineered PROTAC-CID systems for mammalian inducible gene regulation.
    Authors: Ma Et al.
    J Am Chem Soc  2023;145:1593
  2. Regulation of CD45 phosphatase by oncogenic ALK in anaplastic large cell lymphoma.
    Authors: Martina Et al.
    Front Oncol  2023;12:1085672
  3. Tyrosine phosphatases regulate resistance to ALK inhibitors in ALK+ anaplastic large cell lymphoma.
    Authors: Cinzia Et al.
    Blood  2022;139:717-731

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