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TL 13-110

Catalog #: 6746 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6746/5
TL 13-110 | CAS No. 2229037-09-4 | Active Degrader Negative Controls
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Description: Negative control for TL 13-112 (Cat. No. 6745)

Chemical Name: N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)piperidin-1-yl)ethoxy)ethoxy)ethyl)-2-((1,3-dioxo-2-(2-oxopiperidin-3-yl)isoindolin-4-yl)amino)acetamide

Purity: ≥98%

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Biological Activity

TL 13-110 is a negative control for TL 13-112 (Cat. No. 6745). Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM).

Technical Data

M.Wt:
988.59
Formula:
C49H62ClN9O9S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2229037-09-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license from Dana-Farber Cancer Institute

Background References

  1. Chemically induced degradation of anaplastic lymphoma kinase.
    Powell et al.
    J.Med.Chem., 2018;61:4249

Product Datasheets

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