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Sacubitril calcium

Catalog #: 5772 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5772/10
5772/50
Sacubitril calcium | CAS No. 1369773-39-6 | Additional Synthetic Protease Inhibitors
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Description: Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable
Alternative Names: AHU 377

Chemical Name: Ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl-[1,1'-biphenyl]-4-pentanoate hemicalcium salt

Purity: ≥98%

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Biological Activity

Sacubitril calcium is a membrane metallo-endopeptidase (neprilysin) inhibitor prodrug. Increases ANF-induced natriuresis without affecting diuresis in rats. Orally bioavailable.

Technical Data

M.Wt:
430.52
Formula:
C24H28NO5.½Ca
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1369773-39-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors.
    Ksander et al.
    J.Med.Chem., 1995;38:1689

Product Datasheets

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