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RS 17053 hydrochloride

Catalog #: 0985 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0985/10
0985/50
RS 17053 hydrochloride | CAS No. 169505-93-5 | Adrenergic alpha-1 Receptor Antagonists
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Description: α1A antagonist

Chemical Name: (N-[2-(2-Cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α,α-dimethyl-1H-indole-3-ethanamine) hydrochloride

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Biological Activity

RS 17053 hydrochloride is an α1A-adrenoceptor antagonist, with very high affinity for α1A receptors (pKi and pA2 estimates of 9.1 - 9.9) and a 30 - 100 fold selectivity over the α1B and α1D subtypes (pKi and pA2 estimates 7.7 - 7.8).

Technical Data

M.Wt:
449.42
Formula:
C24H29N2O2Cl.HCl
Solubility:
Soluble to 10 mM in ethanol and to 50 mM in DMSO
Storage:
Store at RT
CAS No:
169505-93-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Roche Bioscience

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Different subtypes of α1A-adrenoceptor mediating contraction of rat epididymal vas deferens, rat hepatic portal vein and human prostate distinguished by the antagonist RS 17053.
    Marshall et al.
    Br.J.Pharmacol., 1996;119:407
  3. Do α1A (α1C)-adrenoceptors (AR) mediate prostatic smooth muscle contraction in man? Studies with a novel, selective α1A-AR antagonist, RS 17053.
    Ford et al.
    Br.J.Pharmacol., 1995;114:C25
  4. RS 17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α,α-dimethyl-1H-indole-3-ethanamine hydrochloride, a selective α1A-adrenoceptor antagonist, displays low affinity for functional α1-adrenoceptors in huma
    Ford et al.
    Mol.Pharmacol., 1996;49:209

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