RS 100329 hydrochloride
Chemical Name: 5-Methyl-3-[3-[3-[4-[2-(2,2,2,-trifluroethoxy)phenyl]-1-piperazinyl]propyl]-2,4-(1H,3H)-pyrimidinedione hydrochloride
Purity: ≥99%
Biological Activity
RS 100329 hydrochloride is a subtype-selective α1A-adrenoceptor antagonist (pKi = 9.6 for human cloned α1A receptors). Displays 126- and 50-fold selectivity over human α1B and α1D receptors respectively. Active in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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The role of α1-adrenoceptors and 5-HT1A receptors in the control of the micturition reflex in male anaesthetized rats.
Conley et al.
Br.J.Pharmacol., 2001;133:61 -
α1L-Adrenoceptor mediation of smooth muscle contraction in rabbit bladder neck: a model for lower urinary tract tissues of man.
Shannon Kava et al.
Br.J.Pharmacol., 1998;123:1359 -
In vitro α1-adrenoceptor pharmacology of Ro 70-0004 and RS-100329, novel α1A-adrenoceptor selective antagonists.
Williams et al.
Br.J.Pharmacol., 1999;127:252
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Citations for RS 100329 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for RS 100329 hydrochloride include:
3 Citations: Showing 1 - 3
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Identification of a new pharmacological activity of the phenylpiperazine derivative naftopidil: tubulin-binding drug.
Authors: Ishii and Sugimura
Front Cell Neurosci 2015;8:42618
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High vascular tone of mouse femoral arteries in vivo is determined by sympathetic nerve activity via α1A- and α1D-adrenoceptor subtypes.
Authors: Zacharia Et al.
PLoS One 2013;8:e65969
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Sympathectomy reveals alpha 1A- and alpha 1D-adrenoceptor components to contractions to noradrenaline in rat vas deferens.
Authors: Cleary Et al.
Br J Pharmacol 2004;143:745
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