Recombinant Mouse BMPR-IA/ALK-3 Fc Chimera Protein Summary
Product Specifications
| Mouse BMPR-IA (Gln24 - Arg152) Accession # Q60607 |
IEGRMD | Human IgG1 (Pro100 - Lys330) |
6-His tag |
| N-terminus | C-terminus | ||
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
437-MR
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein. |
| Reconstitution | Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
437-MR/CF
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
| Reconstitution | Reconstitute at 100 μg/mL in sterile PBS. |
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Reconstitution Calculator
Background: BMPR-IA/ALK-3
Bone Morphogenetic Protein Receptor IA (BMPR-IA), also known as ALK-3, BRK-1, and CD292, is a glycosylated 60 ‑ 65 kDa type I receptor in the TGF‑ beta serine/threonine kinase receptor family (1 ‑ 3). Binding of TGF‑ beta superfamily ligands induces formation of a heterotetrameric complex that contains two chains each of a type I and a type II receptor in multiple combinations. The type II receptors phosphorylate the type I receptors which then phosphorylate and activate Smad signal transduction proteins (1, 2). Mature mouse BMPR-IA consisits of a 129 amino acid (aa) extracellular domain (ECD), a 24 aa transmembrane segment, and a 356 aa cytoplasmic region that contains the tyrosine kinase domain (4, 5). Within the ECD, mouse BMPR-IA shares 98% aa sequence identity with human and rat BMPR-IA. BMPR-IA is involved in the development and function of a wide range of tissues. During early embryogenesis it is required for migration of the anterior visceral endoderm (AVE) and proper development of the anterior-posterior axis (6). Tissue-specific conditional knockout experiments have demonstrated the importance of BMPR-IA in the development and morphogenesis of the heart, lung, palate, teeth, and mandible (7 - 9). In the adult, BMPR-IA plays a role in glucose-stimulated insulin secretion by pancreatic beta cells, osteoclast activity and bone remodeling, reactive astrocyte-mediated scar formation following spinal cord injury, and ovulation and fertility (10 - 13).
- Wu, M.Y. and C.S. Hill (2009) Dev. Cell 16:329.
- Nickel, J. et al. (2009) Cytokine Growth Factor Rev. 20:367.
- de Caestecker, M. (2004) Cytokine Growth Factor Rev. 15:1.
- Dewulf, N. et al. (1995) Endocrinology 136:2652.
- Koenig, B.B. et al. (1994) Mol. Cell. Biol. 14:5961.
- Miura, S. et al. (2010) Dev. Biol. 341:246.
- Gaussin, V. et al. (2002) Proc. Natl. Acad. Sci. 99:2878.
- Sun, J. et al. (2008) Am. J. Pathol. 172:571.
- Li, L. et al. (2011) Dev. Biol. 349:451.
- Goulley, J. et al. (2007) Cell Metab. 5:207.
- Kamiya, N. et al. (2008) J. Bone Miner. Res. 23:2007.
- Sahni, V. et al. (2010) J. Neurosci. 30:1839.
- Edson, M.A. et al. (2010) Mol. Endocrinol. 24:1251.
Citations for Recombinant Mouse BMPR-IA/ALK-3 Fc Chimera Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs.
Authors: Chen, Jiekai, Liu, He, Liu, Jing, Qi, Jing, Wei, Bei, Yang, Jiaqi, Liang, Hanquan, Chen, You, Chen, Jing, Wu, Yaran, Guo, Lin, Zhu, Jieying, Zhao, Xiangjie, Peng, Tianran, Zhang, Yixin, Chen, Shen, Li, Xuejia, Li, Dongwei, Wang, Tao, Pei, Duanqing
Nat Genet, 2012-12-02;45(1):34-42.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
BMP signalling permits population expansion by preventing premature myogenic differentiation in muscle satellite cells.
Authors: Ono Y, Calhabeu F, Morgan JE
Cell Death Differ., 2010-08-06;18(2):222-34.
Species: Mouse
Sample Types: In Vivo, Whole Cells
Applications: Bioassay, In Vivo -
ALK1 signaling regulates early postnatal lymphatic vessel development.
Authors: Niessen K, Zhang G, Ridgway JB, Chen H, Yan M
Blood, 2009-11-10;115(8):1654-61.
Applications: ELISA (Standard) -
Developmental pattern of expression of BMP receptors and Smads and activation of Smad1 and Smad5 by BMP9 in mouse basal forebrain.
Authors: Lopez-Coviella I, Mellott TM, Kovacheva VP, Berse B, Slack BE, Zemelko V, Schnitzler A, Blusztajn JK
Brain Res., 2006-04-13;1088(1):49-56.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay
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