Home / Noggin / Recombinant Human Noggin Protein

Recombinant Human Noggin Protein

Catalog #: 6057-NG
207 Citations 9 Reviews Datasheet / COA / SDS
GMP Version Available: 6057-GMP
GMP
Analyzed by SEC-MALS

Carrier Free

Catalog # Availability Size / Price Qty
6057-NG-025/CF
6057-NG-100/CF
6057-NG-01M/CF

With Carrier

Catalog # Availability Size / Price Qty
6057-NG-025
6057-NG-100
6057-NG-01M
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Recombinant Human Noggin Protein SEC-MALS.
6 Images
Product Details
Citations (207)
FAQs
Supplemental Products
Reviews (9)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human Noggin Protein Summary

Product Specifications

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to inhibit BMP-4-induced alkaline phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 0.0200-0.160 μg/mL in the presence of 50 ng/mL of Recombinant Human BMP‑4 (Catalog # 314-BP).
Source
Mouse myeloma cell line, NS0-derived human Noggin protein
Gln28-Cys232
Accession #
Q13253
N-terminal Sequence
Analysis
No results obtained: Gln28 predicted
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
23 kDa (monomer)
SDS-PAGE
30-33 kDa, reducing conditions

Product Datasheets

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6057-NG (with carrier)

Product Datasheet
COA
SDS

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6057-NG/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

6057-NG

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 250 μg/mL in PBS  containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

6057-NG/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 250 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

SEC-MALS View Larger

Recombinant human Noggin (Catalog # 6057-NG) has a molecular weight (MW) of 58.9 kDa as analyzed by SEC-MALS, suggesting that this protein is a homodimer.  MW may differ from predicted MW due to post-translational modifications (PTMs) present (i.e. Glycosylation).

Bioactivity Superior and Consistent Pluripotent Stem Cell Differentiation with R&D Systems Recombinant Human Noggin. View Larger

BG01V human embryonic stem cells were cultured in Mouse Embryonic Fibroblast Conditioned Media supplemented with FGF basic (5 ng/mL). Stem cells were driven into early cells of the neuroectoderm using a 3 day incubation in recombinant human Noggin (25 µg/mL) from either R&D Systems (Lot 1, Lot 2; Catalog # 6057-NG) or from two separate competitors (Competitor 1, Competitor 2). Control cells were not incubated in Noggin (No Noggin). The cells were stained for the early ectoderm marker, Otx2, and the neuroectoderm marker, SOX1. (A) Representative images of SOX1 (green), Otx2 (red), and DAPI (blue) staining in embryonic stem cells differentiated with Noggin from R&D Systems or Noggin from Competitor 2. (B) SOX1+ clusters were quantified under each of the indicated culture conditions. Cells treated with R&D Systems Noggin showed an increase in SOX1+ cells compared to both untreated and competitor-treated cells. R&D Systems Noggin showed consistent differentiation across the lots tested. BG01V human embryonic stem cells are licensed from ViaCyte, Inc.

Bioactivity Superior and Consistent Pluripotent Stem Cell Differentiation with R&D Systems Recombinant Human Noggin. View Larger

Recombinant Human Noggin (Catalog # 6057-NG) inhibits BMP-4 induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line. The activity is approximately 30-fold greater than the top competitor's Noggin.

Bioactivity View Larger

The lot-to-lot consistency of Recombinant Human Noggin (Catalog # 6057-NG) was assessed by testing the ability of three independent lots of the protein to inhibit BMP-4-induced alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line (orange, green, red lines). Each trace on the graph represents data obtained from Recombinant Human Noggin from a different manufacturing run. The ED50 for this effect is 0.020-0.160 ug/mL in the presence of 50 ng/mL Recombinant Human BMP-4 (314-BP). The dark blue line on the graph is showing the ability of Recombinant Human BMP-4 (ng/mL) to induce alkaline phosphatase production in the ATDC5 mouse chondrogenic cell line.

Bioactivity View Larger

iPSC-derived cerebral organoids (day 45) were cultured using Cultrex UltiMatrix RGF Basement Membrane Extract (BME001-05) and brain organoid culture medium, which includes Recombinant Human FGF-basic (3718-FB) and Recombinant Human Noggin (Catalog # 6057-NG), along with the other reagents listed in the brain organoid culture recipe. Cerebral organoids were stained for Syto6 (blue), Pax6 (red), and Vimentin (green). (A) Image taken at 4x magnification. (B) An enlarged view of the area shown within the white box in part A of the figure. (C) Image taken at 15x magnification. Images courtesy of LifeCanvas Technologies.

Bioactivity View Larger

iPSC-derived cerebral organoids (day 45) were cultured using Cultrex UltiMatrix RGF Basement Membrane Extract (BME001-05) and brain organoid culture medium, which includes Recombinant Human FGF-basic (3718-FG) and Recombinant Human Noggin (Catalog # 6057-NG), along with the other reagents listed in the brain organoid culture recipe. (A) Representative brightfield image of day 30 iPSC-derived cerebral organoids. (B) Cerebral organoids stained for beta III-tubulin (green) and Prox1 (red), and counterstained with DAPI (blue).

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Noggin

Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs) (1, 2). Human Noggin cDNA encodes a 232 amino acid (aa) precursor protein; cleavage of a 19 aa signal peptide generates the 213 aa mature protein which contains an N-terminal acidic region, a central basic heparin‑binding segment and a C-terminal cysteine-knot structure (2). Secreted Noggin probably remains close to the cell surface due to its binding of heparin‑containing proteoglycans (3). Noggin is very highly conserved among vertebrates, such that mature human Noggin shares 99%, 99%, 98%, 97% and 89% aa sequence identity with mouse, rat, bovine, equine and chicken Noggin, respectively. Noggin binds some BMPs such as BMP-4 with high affinity and others such as BMP-7 with lower affinity. It antagonizes BMP bioactivities by blocking epitopes on BMPs that are needed for binding to both type I and type II receptors (2, 4). During embryogenesis, Noggin antagonizes specific BMPs at defined times, for example, during neural tube, somite and cardiomyocyte growth and patterning (5-7). During skeletal development, Noggin prevents chondrocyte hyperplasia, thus allowing proper formation of joints (4). Mutations within the cysteine-knot region of human Noggin are linked to multiple types of skeletal dysplasias that result in apical joint fusions (8). Noggin is expressed in defined areas of the adult central nervous system and peripheral tissues such as lung, skeletal muscle and skin (1). During culture of human embryonic stem cells (hESC) or neural stem cells under certain conditions, addition of Noggin to antagonize BMP activity may allow stem cells to proliferate while maintaining their undifferentiated state, or alternatively, to differentiate into dopaminergic neurons (6, 9 - 13). Noggin also appears to maintain adult stem cell populations in-vivo, for example, maintaining neural stem cells within the hippocampus (13).

References
  1. Valenzuela, D.M. et al. (1995) J. Neurosci. 15:6077.
  2. Groppe, J. et al. (2002) Nature 420:636.
  3. Paine-Saunders, S et al. (2002) J. Biol. Chem. 277:2089.
  4. Brunet, L. J. et al. (1998) Science 280:1455.
  5. McMahon, J. A. et al. (1998) Genes Dev. 12:1438.
  6. Itsykson, P. et al. (2005) Mol. Cell. Neurosci. 30:24.
  7. Yuasa, S. et al. (2005) Nat. Biotechnol. 23:607.
  8. Gong, Y. et al. (1999) Nat. Genet. 21:302.
  9. Xu, R.-H. et al. (2005) Nat. Methods 2:185.
  10. Wang, G. et al. (2005) Biochem. Biophys. Res. Commun. 330:934.
  11. Chaturvedi, G. et al. (2009) Cell Prolif. 42:425.
  12. Chiba, S. et al. (2008) Stem Cells 26:2810.
  13. Bonaguidi, M.A. et al. (2008) J. Neurosci. 28:9194.
Entrez Gene IDs
9241 (Human); 18121 (Mouse)
Alternate Names
NOG; Noggin; SYM1; symphalangism 1 (proximal); synostoses (multiple) syndrome 1; SYNS1; SYNS1A

Citations for Recombinant Human Noggin Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

207 Citations: Showing 1 - 10
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  1. Establishment of human pluripotent stem cell-derived cortical neurosphere model to study pathomechanisms and chemical toxicity in Kleefstra syndrome
    Authors: Balogh, A;Bódi-Jakus, M;Karl, VR;Bellák, T;Széky, B;Farkas, J;Lamberto, F;Novak, D;Fehér, A;Zana, M;Dinnyés, A;
    Scientific reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Enhanced Maturity and Functionality of Vascularized Human Liver Organoids through 3D Bioprinting and Pillar Plate Culture
    Authors: Lekkala, VKR;Shrestha, S;Al Qaryoute, A;Dhinoja, S;Acharya, P;Raheem, A;Jagadeeswaran, P;Lee, MY;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. NUAK1 activates STAT5/GLI1/SOX2 signaling to enhance cancer cell expansion and drives chemoresistance in gastric cancer
    Authors: Cao, L;Lin, G;Fan, D;Weng, K;Chen, Y;Wang, J;Li, P;Zheng, C;Huang, C;Xie, J;
    Cell reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Glycogen myophosphorylase loss causes increased dependence on glucose in iPSC-derived retinal pigment epithelium
    Authors: Basu, B;Karwatka, M;China, B;McKibbin, M;Khan, K;Inglehearn, CF;Ladbury, JE;Johnson, CA;
    The Journal of biological chemistry
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Ube3a unsilencer for the potential treatment of Angelman syndrome
    Authors: Vihma, H;Li, K;Welton-Arndt, A;Smith, AL;Bettadapur, KR;Gilmore, RB;Gao, E;Cotney, JL;Huang, HC;Collins, JL;Chamberlain, SJ;Lee, HM;Aubé, J;Philpot, BD;
    Nature communications
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Paracrinal regulation of neutrophil functions by coronaviral infection in iPSC-derived alveolar type II epithelial cells
    Authors: Chien, Y;Huang, XY;Yarmishyn, AA;Chien, CS;Liu, YH;Hsiao, YJ;Lin, YY;Lai, WY;Huang, SC;Lee, MS;Chiou, SH;Yang, YP;Chiou, GY;
    Virus research
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. The secreted protein Amuc_1409 from Akkermansia muciniphila improves gut health through intestinal stem cell regulation
    Authors: Kang, EJ;Kim, JH;Kim, YE;Lee, H;Jung, KB;Chang, DH;Lee, Y;Park, S;Lee, EY;Lee, EJ;Kang, HB;Rhyoo, MY;Seo, S;Park, S;Huh, Y;Go, J;Choi, JH;Choi, YK;Lee, IB;Choi, DH;Seo, YJ;Noh, JR;Kim, KS;Hwang, JH;Jeong, JS;Kwon, HJ;Yoo, HM;Son, MY;Kim, YG;Lee, DH;Kim, TY;Kwon, HJ;Kim, MH;Kim, BC;Kim, YH;Kang, D;Lee, CH;
    Nature communications
    Species: Human
    Sample Types: Spheroid
    Applications: Bioassay
  8. Tofacitinib uptake by patient-derived intestinal organoids predicts individual clinical responsiveness
    Authors: Jang, KK;Ercelen, D;Cen Feng, JYC;Gurunathan, S;Zhou, C;Korman, A;Newell, L;Hudesman, D;Jones, DR;Loke, P;Axelrad, JE;Cadwell, K;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  9. Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain
    Authors: Wang, M;Zhang, L;Novak, SW;Yu, J;Gallina, IS;Xu, LL;Lim, CK;Fernandes, S;Shokhirev, MN;Williams, AE;Saxena, MD;Coorapati, S;Parylak, SL;Quintero, C;Molina, E;Andrade, LR;Manor, U;Gage, FH;
    Nature biotechnology
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Chemically-defined and scalable culture system for intestinal stem cells derived from human intestinal organoids
    Authors: Kwon, O;Lee, H;Jung, J;Son, YS;Jeon, S;Yoo, WD;Son, N;Jung, KB;Choi, E;Lee, IC;Kwon, HJ;Kim, C;Lee, MO;Cho, HS;Kim, DS;Son, MY;
    Nature communications
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation
  11. ROR2 expression predicts human induced pluripotent stem cell differentiation into neural stem/progenitor cells and GABAergic neurons
    Authors: Kuroda, T;Yasuda, S;Matsuyama, S;Miura, T;Sawada, R;Matsuyama, A;Yamamoto, Y;Morioka, MS;Kawaji, H;Kasukawa, T;Itoh, M;Akutsu, H;Kawai, J;Sato, Y;
    Scientific reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain-striatum-cortex assembloids
    Authors: Reumann, D;Krauditsch, C;Novatchkova, M;Sozzi, E;Wong, SN;Zabolocki, M;Priouret, M;Doleschall, B;Ritzau-Reid, KI;Piber, M;Morassut, I;Fieseler, C;Fiorenzano, A;Stevens, MM;Zimmer, M;Bardy, C;Parmar, M;Knoblich, JA;
    Nature methods
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  13. Development of functional resident macrophages in human pluripotent stem cell-derived colonic organoids and human fetal colon
    Authors: Múnera, JO;Kechele, DO;Bouffi, C;Qu, N;Jing, R;Maity, P;Enriquez, JR;Han, L;Campbell, I;Mahe, MM;McCauley, HA;Zhang, X;Sundaram, N;Hudson, JR;Zarsozo-Lacoste, A;Pradhan, S;Tominaga, K;Sanchez, JG;Weiss, AA;Chatuvedi, P;Spence, JR;Hachimi, M;North, T;Daley, GQ;Mayhew, CN;Hu, YC;Takebe, T;Helmrath, MA;Wells, JM;
    Cell stem cell
    Applications: Cell Culture
  14. Bovine oviductal organoids: a multi-omics approach to capture the cellular and extracellular molecular response of the oviduct to heat stress
    Authors: Menjivar, NG;Gad, A;Thompson, RE;Meyers, MA;Hollinshead, FK;Tesfaye, D;
    BMC genomics
    Species: Bovine
    Sample Types: Organoids
    Applications: Bioassay
  15. Disentangling the innate immune responses of intestinal epithelial cells and lamina propria cells to Salmonella Typhimurium infection in chickens
    Authors: Sutton, K;Nash, T;Sives, S;Borowska, D;Mitchell, J;Vohra, P;Stevens, MP;Vervelde, L;
    Frontiers in microbiology
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Oncogenic KRAS drives lipo-fibrogenesis to promote angiogenesis and colon cancer progression
    Authors: Hsu, WH;LaBella, KA;Lin, Y;Xu, P;Lee, R;Hsieh, CE;Yang, L;Zhou, A;Blecher, JM;Wu, CJ;Lin, K;Shang, X;Jiang, S;Spring, DJ;Xia, Y;Chen, P;Shen, JP;Kopetz, S;DePinho, RA;
    Cancer discovery
    Species: Xenograft
    Sample Types: Whole Cells
    Applications: Bioassay
  17. An integrated organoid omics map extends modeling potential of kidney disease
    Authors: Lassé, M;El Saghir, J;Berthier, CC;Eddy, S;Fischer, M;Laufer, SD;Kylies, D;Hutzfeldt, A;Bonin, LL;Dumoulin, B;Menon, R;Vega-Warner, V;Eichinger, F;Alakwaa, F;Fermin, D;Billing, AM;Minakawa, A;McCown, PJ;Rose, MP;Godfrey, B;Meister, E;Wiech, T;Noriega, M;Chrysopoulou, M;Brandts, P;Ju, W;Reinhard, L;Hoxha, E;Grahammer, F;Lindenmeyer, MT;Huber, TB;Schlüter, H;Thiel, S;Mariani, LH;Puelles, VG;Braun, F;Kretzler, M;Demir, F;Harder, JL;Rinschen, MM;
    Nature communications
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Deregulation of mTORC1-TFEB axis in human iPSC model of GBA1-associated Parkinson's disease
    Authors: Mubariz, F;Saadin, A;Lingenfelter, N;Sarkar, C;Banerjee, A;Lipinski, MM;Awad, O;
    Frontiers in neuroscience
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Blockage of retinoic acid signaling via RAR? suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase
    Authors: Yamakawa, K;Koyanagi-Aoi, M;Machinaga, A;Kakiuchi, N;Hirano, T;Kodama, Y;Aoi, T;
    Cancer cell international
    Species: Human
    Sample Types: Organoid
    Applications: Cell Culture
  20. A distal lung organoid model to study interstitial lung disease, viral infection and human lung development
    Authors: Matkovic Leko, I;Schneider, RT;Thimraj, TA;Schrode, N;Beitler, D;Liu, HY;Beaumont, K;Chen, YW;Snoeck, HW;
    Nature protocols
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  21. Organoid modeling of lung-resident immune responses to SARS-CoV-2 infection
    Authors: Kuo, C;Choi, S;van Unen, V;Zhang, H;Rustagi, A;Alwahabi, S;Santos, A;Chan, J;Lam, B;Solis, D;Mah, J;R�ltgen, K;Trope, W;Guh-Siesel, A;Lin, Z;Beck, A;Edwards, C;Mallajosyula, V;Martin, B;Dunn, J;Shrager, J;Baric, R;Pinsky, B;Boyd, S;Blish, C;Davis, M;
    Research square
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Bioassay
  22. Bone Morphogenetic Protein-4 Impairs Retinal Endothelial Cell Barrier, a Potential Role in Diabetic Retinopathy
    Authors: Darwish, NHE;Hussein, KA;Elmasry, K;Ibrahim, AS;Humble, J;Moustafa, M;Awadalla, F;Al-Shabrawey, M;
    Cells
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Vibrio cholerae biofilms use modular adhesins with glycan-targeting and nonspecific surface binding domains for colonization
    Authors: X Huang, T Nero, R Weeraseker, KH Matej, A Hinbest, Z Jiang, RF Lee, L Wu, C Chak, J Nijjer, I Gibaldi, H Yang, N Gamble, WL Ng, SA Malaker, K Sumigray, R Olson, J Yan
    Nature Communications, 2023-04-13;14(1):2104.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Activation of AKT induces EZH2-mediated beta-catenin trimethylation in colorectal cancer
    Authors: AH Ghobashi, TT Vuong, JW Kimani, HM O'Hagan
    bioRxiv : the preprint server for biology, 2023-02-04;0(0):.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  25. Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial
    Authors: J Tian, JH Chen, SX Chao, K Pelka, M Giannakis, J Hess, K Burke, V Jorgji, P Sindurakar, J Braverman, A Mehta, T Oka, M Huang, D Lieb, M Spurrell, JN Allen, TA Abrams, JW Clark, AC Enzinger, PC Enzinger, SJ Klempner, NJ McCleary, JA Meyerhardt, DP Ryan, MB Yurgelun, K Kanter, EE Van Sevent, I Baiev, G Chi, J Jarnagin, WB Bradford, E Wong, AG Michel, IJ Fetter, G Siravegna, AJ Gemma, A Sharpe, S Demehri, R Leary, CD Campbell, O Yilmaz, GA Getz, AR Parikh, N Hacohen, RB Corcoran
    Nature Medicine, 2023-01-26;0(0):.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  26. Epigenetic and transcriptional regulations prime cell fate before division during human pluripotent stem cell differentiation
    Authors: P Madrigal, S Deng, Y Feng, S Militi, KJ Goh, R Nibhani, R Grandy, A Osnato, D Ortmann, S Brown, S Pauklin
    Nature Communications, 2023-01-25;14(1):405.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation
    Authors: YF Wong, Y Kumar, M Proks, JAR Herrera, MM Rothová, RS Monteiro, S Pozzi, RE Jennings, NA Hanley, WA Bickmore, JM Brickman
    Nature Cell Biology, 2023-01-23;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Hypoxia-tolerant apical-out intestinal organoids to model host-microbiome interactions
    Authors: P Kakni, B Jutten, D Teixeira O, J Penders, R Truckenmül, P Habibovic, S Giselbrech
    Journal of tissue engineering, 2023-01-18;14(0):2041731422114.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Targeting TBK1 to overcome resistance to cancer immunotherapy
    Authors: Y Sun, OY Revach, S Anderson, EA Kessler, CH Wolfe, A Jenney, CE Mills, EJ Robitschek, TGR Davis, S Kim, A Fu, X Ma, J Gwee, P Tiwari, PP Du, P Sindurakar, J Tian, A Mehta, AM Schneider, K Yizhak, M Sade-Feldm, T LaSalle, T Sharova, H Xie, S Liu, WA Michaud, R Saad-Beret, KB Yates, A Iracheta-V, JKE Spetz, X Qin, KA Sarosiek, G Zhang, JW Kim, MY Su, AM Cicerchia, MQ Rasmussen, SJ Klempner, D Juric, SI Pai, DM Miller, A Giobbie-Hu, JH Chen, K Pelka, DT Frederick, S Stinson, E Ivanova, AR Aref, CP Paweletz, DA Barbie, DR Sen, DE Fisher, RB Corcoran, N Hacohen, PK Sorger, KT Flaherty, GM Boland, RT Manguso, RW Jenkins
    Nature, 2023-01-12;0(0):.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  30. Programming Multicellular Assembly with Synthetic Cell Adhesion Molecules
    Authors: AJ Stevens, AR Harris, J Gerdts, KH Kim, C Trentesaux, JT Ramirez, WL McKeithan, F Fattahi, OD Klein, DA Fletcher, WA Lim
    Nature, 2022-12-12;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Generation and cryopreservation of feline oviductal organoids
    Authors: RE Thompson, MA Meyers, C Premananda, FK Hollinshea
    Theriogenology, 2022-11-17;196(0):167-173.
    Species: Feline
    Sample Types: Organoids
    Applications: Bioassay
  32. Membrane Attack Complex Mediates Retinal Pigment Epithelium Cell Death in Stargardt Macular Degeneration
    Authors: ESY Ng, N Kady, J Hu, A Dave, Z Jiang, J Pei, MB Gorin, A Matynia, RA Radu
    Cells, 2022-11-02;11(21):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Quantitative analysis of transcriptome dynamics provides novel insights into developmental state transitions
    Authors: K Johnson, S Freedman, R Braun, C LaBonne
    BMC Genomics, 2022-10-23;23(1):723.
    Species: Frog
    Sample Types:
    Applications: Bioassay
  34. Modeling native and seeded Synuclein aggregation and related cellular dysfunctions in dopaminergic neurons derived by a new set of isogenic iPSC lines with SNCA multiplications
    Authors: A Iannielli, M Luoni, SG Giannelli, R Ferese, G Ordazzo, M Fossati, A Raimondi, F Opazo, O Corti, JHM Prehn, S Gambardell, R Melki, V Broccoli
    Cell Death & Disease, 2022-10-19;13(10):881.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Antibody targeting of E3 ubiquitin ligases for receptor degradation
    Authors: H Marei, WK Tsai, YS Kee, K Ruiz, J He, C Cox, T Sun, S Penikalapa, P Dwivedi, M Choi, D Kan, P Saenz-Lope, K Dorighi, P Zhang, YT Kschonsak, N Kljavin, D Amin, I Kim, AG Mancini, T Nguyen, C Wang, E Janezic, A Doan, E Mai, H Xi, C Gu, M Heinlein, B Biehs, J Wu, I Lehoux, S Harris, L Comps-Agra, D Seshasayee, FJ de Sauvage, M Grimmer, J Li, NJ Agard, F de Sousa E
    Nature, 2022-09-21;610(7930):182-189.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  36. Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systems
    Authors: K Kishimoto, K Iwasawa, A Sorel, C Ferran-Her, L Han, M Morimoto, JM Wells, T Takebe, AM Zorn
    Nature Protocols, 2022-08-17;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  37. Fluvastatin promotes chondrogenic differentiation of adipose-derived mesenchymal stem cells by inducing bone morphogenetic protein 2
    Authors: M Kuwahara, Y Akasaki, N Goto, I Kurakazu, T Sueishi, M Toya, T Uchida, T Tsutsui, R Hirose, H Tsushima, Y Nakashima
    Bmc Pharmacology & Toxicology, 2022-08-09;23(1):61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Sox2 in the dermal papilla regulates hair follicle pigmentation
    Authors: KJ Ng, J Lim, YN Tan, D Quek, Z Lim, N Pantelirei, C Clavel
    Oncogene, 2022-07-19;40(3):111100.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  39. Early Signs of Molecular Defects in iPSC-Derived Neural Stems Cells from Patients with Familial Parkinson's Disease
    Authors: E Akrioti, T Karamitros, P Gkaravelas, G Kouroupi, R Matsas, E Taoufik
    Biomolecules, 2022-06-23;12(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Delamination of trophoblast-like syncytia from the amniotic ectodermal analogue in human primed embryonic stem cell-based differentiation model
    Authors: M Ohgushi, N Taniyama, A Vandenbon, M Eiraku
    Cell Reports, 2022-06-21;39(12):110973.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Equine Oviductal Organoid Generation and Cryopreservation
    Authors: RE Thompson, MA Meyers, DNR Veeramacha, BS Pukazhenth, FK Hollinshea
    Methods and protocols, 2022-06-15;5(3):.
    Species: Equine
    Sample Types: Organoid
    Applications: Bioassay
  42. Patient-derived micro-organospheres enable clinical precision oncology
    Authors: S Ding, C Hsu, Z Wang, NR Natesh, R Millen, M Negrete, N Giroux, GO Rivera, A Dohlman, S Bose, T Rotstein, K Spiller, A Yeung, Z Sun, C Jiang, R Xi, B Wilkin, PM Randon, I Williamson, DA Nelson, D Delubac, S Oh, G Rupprecht, J Isaacs, J Jia, C Chen, JP Shen, S Kopetz, S McCall, A Smith, N Gjorevski, AC Walz, S Antonia, E Marrer-Ber, H Clevers, D Hsu, X Shen
    Cell Stem Cell, 2022-05-03;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  43. Modeling Pancreatic Cancer with Patient-Derived Organoids Integrating Cancer-Associated Fibroblasts
    Authors: YH Go, WH Choi, WJ Bae, SI Jung, CH Cho, SA Lee, JS Park, JM Ahn, SW Kim, KJ Lee, D Lee, J Yoo
    Cancers, 2022-04-21;14(9):.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  44. ATG7-mediated autophagy facilitates embryonic stem cell exit from naive pluripotency and marks commitment to differentiation
    Authors: J Zhou, H He, JJ Zhang, X Liu, W Yao, C Li, T Xu, SY Yin, DY Wu, CL Dou, Q Li, J Xiang, WJ Xiong, LY Wang, JM Tang, Z Xue, X Zhang, YL Miao
    Autophagy, 2022-04-10;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Tissue extracellular matrix hydrogels as alternatives to Matrigel for culturing gastrointestinal organoids
    Authors: S Kim, S Min, YS Choi, SH Jo, JH Jung, K Han, J Kim, S An, YW Ji, YG Kim, SW Cho
    Nature Communications, 2022-03-30;13(1):1692.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases
    Authors: JM Suárez-Riv, CJ Pastor-Mal, A Romero-Gon, D Gómez-Fern, S Povea-Cabe, M Álvarez-Có, I Villalón-G, M Talaverón-, A Suárez-Car, M Munuera-Ca, JA Sánchez-Al
    Frontiers in Pharmacology, 2022-03-18;13(0):862085.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids
    Authors: K Uehara, M Koyanagi-A, T Koide, T Itoh, T Aoi
    Stem Cell Reports, 2022-03-03;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  48. OncoSNIPE� Study Protocol, a study of molecular profiles associated with development of resistance in solid cancer patients
    Authors: S Vachenc, J Gobbo, SE Moujarrebe, I Desmoulins, M Gilabert, M Beau-Falle, E Mitry, N Girard, A Bertaut, N Dusetti, JL Iovanna, R Yousfi, F Pierrat, R Bruno, A Cueff, R Boidot, P Genne
    BMC Cancer, 2022-01-06;22(1):41.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  49. Intracameral Microimaging of Maturation of Human iPSC Derivatives into Islet Endocrine Cells
    Authors: K Zhao, Y Shi, J Yu, L Yu, A Mael, Y Li, A Kolton, T Joyce, J Odorico, PO Berggren, SN Yang
    Cell Transplantation, 2022-01-01;31(0):9636897211066.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Programming Multicellular Assembly with Synthetic Cell Adhesion Molecules
    Authors: AJ Stevens, AR Harris, J Gerdts, KH Kim, C Trentesaux, JT Ramirez, WL McKeithan, F Fattahi, OD Klein, DA Fletcher, WA Lim
    Nature, 2022;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Human iPSC-derived fallopian tube organoids with BRCA1 mutation recapitulate early-stage carcinogenesis
    Authors: N Yucer, R Ahdoot, MJ Workman, AH Laperle, MS Recouvreux, K Kurowski, DJ Naboulsi, V Liang, Y Qu, JT Plummer, SA Gayther, S Orsulic, BY Karlan, CN Svendsen
    Cell Reports, 2021-12-28;37(13):110146.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Epithelial phenotype restoring drugs suppress macular degeneration phenotypes in an iPSC model
    Authors: R Sharma, A George, M Nimmagadda, D Ortolan, BS Karla, Z Qureshy, D Bose, R Dejene, G Liang, Q Wan, J Chang, BS Jha, O Memon, KJ Miyagishim, A Rising, M Lal, E Hanson, R King, MM Campos, M Ferrer, J Amaral, D McGaughey, K Bharti
    Nature Communications, 2021-12-15;12(1):7293.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Local non-pituitary growth hormone is induced with aging and facilitates epithelial damage
    Authors: V Chesnokova, S Zonis, A Apostolou, HQ Estrada, S Knott, K Wawrowsky, K Michelsen, A Ben-Shlomo, R Barrett, V Gorbunova, K Karalis, S Melmed
    Cell Reports, 2021-12-14;37(11):110068.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  54. Relevance of biopsy-derived pancreatic organoids in the development of efficient transcriptomic signatures to predict adjuvant chemosensitivity in pancreatic cancer
    Authors: R Nicolle, O Gayet, M Bigonnet, J Roques, B Chanez, F Puleo, J Augustin, JF Emile, M Svrcek, T Arsenijevi, P Hammel, V Rebours, M Giovannini, P Grandval, L Dahan, V Moutardier, E Mitry, JL Van Laethe, JB Bachet, J Cros, J Iovanna, NJ Dusetti
    Translational Oncology, 2021-12-11;16(0):101315.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  55. Reprogramming Human Adult Fibroblasts into GABAergic Interneurons
    Authors: A Bruzelius, S Kidnapilla, J Drouin-Oue, T Stoker, RA Barker, D Rylander O
    Cells, 2021-12-08;10(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Functional human gastrointestinal organoids can be engineered from three primary germ layers derived separately from pluripotent stem cells
    Authors: AK Eicher, DO Kechele, N Sundaram, HM Berns, HM Poling, LE Haines, JG Sanchez, K Kishimoto, M Krishnamur, L Han, AM Zorn, MA Helmrath, JM Wells
    Cell Stem Cell, 2021-12-01;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Novel chicken two-dimensional intestinal model comprising all key epithelial cell types and a mesenchymal sub-layer
    Authors: B Orr, K Sutton, S Christian, T Nash, H Niemann, LL Hansen, MJ McGrew, SR Jensen, L Vervelde
    Veterinary research, 2021-11-24;52(1):142.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Establishment of human induced trophoblast stem-like cells from term villous cytotrophoblasts
    Authors: T Bai, CY Peng, I Aneas, N Sakabe, DF Requena, C Billstrand, M Nobrega, C Ober, M Parast, JA Kessler
    Stem Cell Research, 2021-08-19;56(0):102507.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Generation of equine enteroids and enteroid-derived 2D monolayers that are responsive to microbial mimics
    Authors: S Hellman
    Veterinary research, 2021-08-14;52(1):108.
    Species: Equine
    Sample Types: Organoid
    Applications: Bioassay
  60. Pluripotent stem cell-derived corneal endothelial cells as an alternative to donor corneal endothelium in keratoplasty
    Authors: M Ali, SY Khan, JD Gottsch, EK Hutchinson, A Khan, SA Riazuddin
    Stem Cell Reports, 2021-08-05;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. A pan-cancer organoid platform for precision medicine
    Authors: BM Larsen, M Kannan, LF Langer, BD Leibowitz, A Bentaieb, A Cancino, I Dolgalev, BE Drummond, JR Dry, CS Ho, G Khullar, BA Krantz, B Mapes, KE McKinnon, J Metti, JF Perera, TA Rand, V Sanchez-Fr, JM Shaxted, MM Stein, MA Streit, YC Tan, Y Zhang, E Zhao, J Venkataram, MC Stumpe, JA Borgia, A Masood, DVT Catenacci, JV Mathews, DB Gursel, JJ Wei, TH Welling, DM Simeone, KP White, AA Khan, C Igartua, AA Salahudeen
    Cell Reports, 2021-07-27;36(4):109429.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  62. Porcine small intestinal organoids as a model to explore ETEC-host interactions in the gut
    Authors: B Vermeire, LM Gonzalez, RJJ Jansens, E Cox, B Devriendt
    Veterinary research, 2021-06-26;52(1):94.
    Species: Porcine
    Sample Types: Organoids
    Applications: Bioassay
  63. Exploring the Complementarity of Pancreatic Ductal Adenocarcinoma Preclinical Models
    Authors: O Hoare, N Fraunhoffe, A Elkaoutari, O Gayet, M Bigonnet, J Roques, R Nicolle, C McGuckin, N Forraz, E Sohier, L Tonon, P Wajda, S Boyault, V Attignon, S Tabone-Egl, S Barbier, C Mignard, O Duchamp, J Iovanna, NJ Dusetti
    Cancers, 2021-05-19;13(10):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  64. MeCP2 controls neural stem cell fate specification through miR-199a-mediated inhibition of BMP-Smad signaling
    Authors: H Nakashima, K Tsujimura, K Irie, T Imamura, CA Trujillo, M Ishizu, M Uesaka, M Pan, H Noguchi, K Okada, K Aoyagi, T Andoh-Noda, H Okano, AR Muotri, K Nakashima
    Cell Reports, 2021-05-18;35(7):109124.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  65. Measuring the elastic modulus of soft culture surfaces and three-dimensional hydrogels using atomic force microscopy
    Authors: MDA Norman, SA Ferreira, GM Jowett, L Bozec, E Gentleman
    Nature Protocols, 2021-04-14;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer's disease
    Authors: N Brookhouse, S Raman, C Frisch, G Srinivasan, DA Brafman
    Molecular Psychiatry, 2021-04-09;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Rational design and optimization of synthetic gene switches for controlling cell-fate decisions in pluripotent stem cells
    Authors: V Haellman, P Saxena, Y Jiang, M Fussenegge
    Metabolic engineering, 2021-03-17;65(0):99-110.
    Species: N/A
    Sample Types: Plasmid
    Applications: Bioassay
  68. Farnesyl dimethyl chromanol targets colon cancer stem cells and prevents colorectal cancer metastasis
    Authors: K Husain, D Coppola, CS Yang, MP Malafa
    Scientific Reports, 2021-01-26;11(1):2185.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  69. A quantitative model of cellular decision making in direct neuronal reprogramming
    Authors: A Merlevede, EM Legault, V Drugge, RA Barker, J Drouin-Oue, V Olariu
    Scientific Reports, 2021-01-15;11(1):1514.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity
    Authors: SK Sarvestani, S Signs, B Hu, Y Yeu, H Feng, Y Ni, DR Hill, RC Fisher, S Ferrandon, RK DeHaan, J Stiene, M Cruise, TH Hwang, X Shen, JR Spence, EH Huang
    Nature Communications, 2021-01-11;12(1):262.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  71. Modeling Intestinal Epithelial Response to Interferon-&gamma in Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids
    Authors: MJ Workman, E Troisi, SR Targan, CN Svendsen, RJ Barrett
    International Journal of Molecular Sciences, 2020-12-30;22(1):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  72. Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation
    Authors: J Meisig, N Dreser, M Kapitza, M Henry, T Rotshteyn, J Rahnenführ, JG Hengstler, A Sachinidis, T Waldmann, M Leist, N Blüthgen
    Nucleic Acids Res, 2020-12-16;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  73. Transplantation of Neural Precursors Derived from Induced Pluripotent Cells Preserve Perineuronal Nets and Stimulate Neural Plasticity in ALS Rats
    Authors: S Forostyak, O Forostyak, JCF Kwok, N Romanyuk, M Rehorova, J Kriska, G Dayanithi, R Raha-Chowd, P Jendelova, M Anderova, JW Fawcett, E Sykova
    International Journal of Molecular Sciences, 2020-12-16;21(24):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  74. A microfluidics-based stem cell model of early post-implantation human development
    Authors: Y Zheng, Y Shao, J Fu
    Nature Protocols, 2020-12-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Using systems medicine to identify a therapeutic agent with potential for repurposing in inflammatory bowel disease
    Authors: K Lloyd, S Papoutsopo, E Smith, P Stegmaier, F Bergey, L Morris, M Kittner, H England, D Spiller, MHR White, CA Duckworth, BJ Campbell, V Poroikov, VAP Martins Do, A Kel, W Muller, DM Pritchard, C Probert, MD Burkitt, SysmedIBD
    Dis Model Mech, 2020-11-27;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Dedifferentiation and neuronal repression define familial Alzheimer's disease
    Authors: AB Caldwell, Q Liu, GP Schroth, DR Galasko, SH Yuan, SL Wagner, S Subramania
    Sci Adv, 2020-11-13;6(46):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Direct Conversion of Human Stem Cell-Derived Glial Progenitor Cells into GABAergic Interneurons
    Authors: J Giacomoni, A Bruzelius, CA Stamouli, D Rylander O
    Cells, 2020-11-10;9(11):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. The Fragile X Mental Retardation Protein regulates RIP1K and colorectal cancer resistance to necroptosis
    Authors: A Di Grazia, I Marafini, G Pedini, D Di Fusco, F Laudisi, V Dinallo, E Rosina, C Stolfi, E Franzè, P Sileri, G Sica, G Monteleone, C Bagni, I Monteleone
    Cell Mol Gastroenterol Hepatol, 2020-10-19;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  79. Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons
    Authors: S Nolbrant, J Giacomoni, DB Hoban, A Bruzelius, M Birtele, D Chandler-M, M Pereira, DR Ottosson, SA Goldman, M Parmar
    Stem Cell Reports, 2020-09-24;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis
    Authors: L Han, P Chaturvedi, K Kishimoto, H Koike, T Nasr, K Iwasawa, K Giesbrecht, PC Witcher, A Eicher, L Haines, Y Lee, JM Shannon, M Morimoto, JM Wells, T Takebe, AM Zorn
    Nat Commun, 2020-08-27;11(1):4158.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  81. Generation of Functional Brown Adipocytes from Human Pluripotent Stem Cells via Progression through a Paraxial Mesoderm State
    Authors: L Zhang, J Avery, A Yin, AM Singh, TS Cliff, H Yin, S Dalton
    Cell Stem Cell, 2020-08-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Mapping developmental trajectories and subtype diversity of normal and glaucomatous human retinal ganglion cells by single-cell transcriptome analysis
    Authors: P Teotia, M Niu, I Ahmad
    Stem Cells, 2020-06-18;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids.
    Authors: Kumar Gupta A, Sarkar P, Wertheim J, Pan X, Carroll T, Oxburgh L
    Commun Biol, 2020-05-11;3(1):231.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  84. LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development
    Authors: NK Vinckier, NA Patel, RJ Geusz, A Wang, J Wang, I Matta, AR Harrington, M Wortham, N Wetton, J Wang, US Jhala, MG Rosenfeld, CW Benner, HP Shih, M Sander
    Nat Commun, 2020-04-29;11(1):2082.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells
    Authors: A Gunne-Brad, A Sullivan, B Gharibi, RSM Sheriff, A Maity, YF Wang, A Edwards, M Jiang, M Howell, R Goldstone, R Wollman, P East, SDM Santos
    Cell Stem Cell, 2020-04-16;26(5):693-706.e9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  86. Generation of intestinal organoids derived from human pluripotent stem cells for drug testing
    Authors: S Yoshida, H Miwa, T Kawachi, S Kume, K Takahashi
    Sci Rep, 2020-04-06;10(1):5989.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells
    Authors: W Liang, P Han, EH Kim, J Mak, R Zhang, AG Torrente, JI Goldhaber, E Marbán, HC Cho
    Stem Cells, 2019-12-30;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Differential susceptibility of human neural progenitors and neurons to ischaemic injury
    Authors: Y Liu, AE Michalska, M Dottori, E Eaton, JM Courtney, A Antonic, DW Howells
    Brain Res. Bull., 2019-12-16;156(0):25-32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  89. Organotypic Cocultures of Human Pluripotent Stem Cell Derived-Neurons with Mammalian Inner Ear Hair Cells and Cochlear Nucleus Slices
    Authors: T Hyakumura, S McDougall, S Finch, K Needham, M Dottori, BA Nayagam
    Stem Cells Int, 2019-11-20;2019(0):8419493.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Oligodendrocyte Intrinsic miR-27a Controls Myelination and Remyelination
    Authors: A Tripathi, C Volsko, JP Garcia, E Agirre, KC Allan, PJ Tesar, BD Trapp, G Castelo-Br, FJ Sim, R Dutta
    Cell Rep, 2019-10-22;29(4):904-919.e9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  91. Activin A receptor type 1-mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD signaling pathway
    Authors: M Omi, V Kaartinen, Y Mishina
    J. Biol. Chem., 2019-10-16;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals
    Authors: T Yung, F Poon, M Liang, S Coquenlorg, EC McGaugh, CC Hui, MD Wilson, MC Nostro, TH Kim
    Nat Commun, 2019-10-11;10(1):4647.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  93. BMP signaling mediates glioma stem cell quiescence and confers treatment resistance in glioblastoma
    Authors: R Sachdeva, M Wu, K Johnson, H Kim, A Celebre, U Shahzad, MS Graham, JA Kessler, JH Chuang, J Karamchand, M Bredel, R Verhaak, S Das
    Sci Rep, 2019-10-10;9(1):14569.
    Species: Human
    Sample Types: Whole Cells
    Applications: Tissue Culture
  94. Targeting chemoresistant colorectal cancer via systemic administration of a BMP7 variant
    Authors: V Veschi, LR Mangiapane, A Nicotra, S Di Franco, E Scavo, T Apuzzo, DS Sardina, M Fiori, A Benfante, ML Colorito, G Cocorullo, F Giuliante, C Cipolla, G Pistone, MR Bongiorno, A Rizzo, CM Tate, X Wu, S Rowlinson, LF Stancato, M Todaro, R De Maria, G Stassi
    Oncogene, 2019-10-07;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  95. Human induced pluripotent stem cell-derived vocal fold mucosa mimics development and responses to smoke exposure
    Authors: V Lungova, X Chen, Z Wang, C Kendziorsk, SL Thibeault
    Nat Commun, 2019-09-24;10(1):4161.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. Controlled modelling of human epiblast and amnion development using stem cells
    Authors: Y Zheng, X Xue, Y Shao, S Wang, SN Esfahani, Z Li, JM Muncie, JN Lakins, VM Weaver, DL Gumucio, J Fu
    Nature, 2019-09-11;573(7774):421-425.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while�repressing genetic programs controlling�serotonin production
    Authors: J Piccand, C Vagne, F Blot, A Meunier, A Beucher, P Strasser, ML Lund, S Ghimire, L Nivlet, C Lapp, N Petersen, MS Engelstoft, C Thibault-C, C Keime, SJ Correa, V Schreiber, N Molina, TW Schwartz, A De Arcange, G Gradwohl
    Mol Metab, 2019-08-13;29(0):24-39.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  98. Patient-derived pancreas-on-a-chip to model cystic fibrosis-related disorders
    Authors: K Shik Mun, K Arora, Y Huang, F Yang, S Yarlagadda, Y Ramananda, M Abu-El-Hai, JJ Palermo, BN Appakalai, JD Nathan, AP Naren
    Nat Commun, 2019-07-16;10(1):3124.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  99. Blockade of STAT3 Causes Severe In Vitro and In Vivo Maturation Defects in Intestinal Organoids Derived from Human Embryonic Stem Cells
    Authors: KB Jung, O Kwon, MO Lee, H Lee, YS Son, O Habib, JH Oh, HS Cho, CR Jung, J Kim, MY Son
    J Clin Med, 2019-07-04;8(7):.
    Species: Human
    Sample Types: Organoid, Whole Cells
    Applications: Bioassay
  100. Examining the fundamental biology of a novel population of directly reprogrammed human neural precursor cells
    Authors: JE Ahlfors, A Azimi, R El-Ayoubi, A Velumian, I Vonderwald, C Boscher, O Mihai, S Mani, M Samoilova, M Khazaei, MG Fehlings, CM Morshead
    Stem Cell Res Ther, 2019-06-13;10(1):166.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  101. Gain of 20q11.21 in Human Pluripotent Stem Cells Impairs TGF-?-Dependent Neuroectodermal Commitment
    Authors: C Markouli, EC De Deckers, M Regin, HT Nguyen, F Zambelli, A Keller, D Dziedzicka, J De Kock, L Tilleman, F Van Nieuwe, L Franceschi, K Sermon, M Geens, C Spits
    Stem Cell Reports, 2019-06-06;13(1):163-176.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Medial artery calcification increases neointimal hyperplasia after balloon injury
    Authors: AP Marshall, W Luo, XL Wang, T Lin, Y Cai, RJ Guzman
    Sci Rep, 2019-06-03;9(1):8193.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Noggin depletion in adipocytes promotes obesity in mice
    Authors: AM Blázquez-M, M Jumabay, P Rajbhandar, T Sallam, Y Guo, J Yao, L Vergnes, K Reue, L Zhang, Y Yao, AM Fogelman, P Tontonoz, AJ Lusis, X Wu, KI Boström
    Mol Metab, 2019-04-10;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Point mutations in the PDX1 transactivation domain impair human ?-cell development and function
    Authors: X Wang, M Sterr, Ansarullah, I Burtscher, A Böttcher, J Beckenbaue, J Siehler, T Meitinger, HU Häring, H Staiger, FM Cernilogar, G Schotta, M Irmler, J Beckers, CVE Wright, M Bakhti, H Lickert
    Mol Metab, 2019-03-20;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation, Differentiation
  105. Brain-stiffness-mimicking tilapia collagen gel promotes the induction of dorsal cortical neurons from human pluripotent stem cells
    Authors: M Iwashita, H Ohta, T Fujisawa, M Cho, M Ikeya, S Kidoaki, Y Kosodo
    Sci Rep, 2019-02-28;9(1):3068.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  106. Excess growth hormone suppresses DNA damage repair in epithelial cells
    Authors: V Chesnokova, S Zonis, R Barrett, H Kameda, K Wawrowsky, A Ben-Shlomo, M Yamamoto, J Gleeson, C Bresee, V Gorbunova, S Melmed
    JCI Insight, 2019-02-07;4(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Generation of lung organoids from human pluripotent stem cells in vitro
    Authors: AJ Miller, BR Dye, D Ferrer-Tor, DR Hill, AW Overeem, LD Shea, JR Spence
    Nat Protoc, 2019-02-01;14(2):518-540.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  108. The Effect of iPS-Derived Neural Progenitors Seeded on Laminin-Coated pHEMA-MOETACl Hydrogel with Dual Porosity in a Rat Model of Chronic Spinal Cord Injury
    Authors: J Ruzicka, N Romanyuk, K Jirakova, A Hejcl, O Janouskova, LU Machova, M Bochin, M Pradny, L Vargova, P Jendelova
    Cell Transplant, 2019-01-18;0(0):9636897188237.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Structurally Conserved Primate LncRNAs Are Transiently Expressed during Human Cortical Differentiation and Influence Cell-Type-Specific Genes
    Authors: AR Field, FMJ Jacobs, IT Fiddes, APR Phillips, AM Reyes-Orti, E LaMontagne, L Whitehead, V Meng, JL Rosenkrant, M Olsen, M Hauessler, S Katzman, SR Salama, D Haussler
    Stem Cell Reports, 2019-01-10;12(2):245-257.
    Species: Human, Primate - Macaca mulatta (Rhesus Macaque), Primate - Pan troglodytes (Chimpanzee), Primate - Pongo (Orangutan)
    Sample Types: Whole Cells
    Applications: Bioassay
  110. High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds
    Authors: STJ Bradford, EJ Ranghini, E Grimley, PH Lee, GR Dressler
    J. Biol. Chem., 2019-01-02;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Generation of human antral and fundic gastric organoids from pluripotent stem cells
    Authors: TR Broda, KW McCracken, JM Wells
    Nat Protoc, 2019-01-01;14(1):28-50.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  112. Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA
    Authors: MA Scavuzzo, J Chmielowie, D Yang, K Wamble, LS Chaboub, L Duraine, B Tepe, SM Glasgow, BR Arenkiel, C Brou, B Deneen, M Borowiak
    Cell Rep, 2018-12-26;25(13):3811-3827.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Expression of the human antimicrobial peptide ?-defensin-1 is repressed by the EGFR-ERK-MYC axis in colonic epithelial cells
    Authors: C Bonamy, E Sechet, A Amiot, A Alam, M Mourez, L Fraisse, PJ Sansonetti, B Sperandio
    Sci Rep, 2018-12-21;8(1):18043.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  114. A transient DMSO treatment increases the differentiation potential of human pluripotent stem cells through the Rb family
    Authors: J Li, C Narayanan, J Bian, D Sambo, T Brickler, W Zhang, S Chetty
    PLoS ONE, 2018-12-12;13(12):e0208110.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  115. Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons
    Authors: N Bayó-Puxan, AP Terrasso, S Creyssels, D Simão, C Begon-Pesc, M Lavigne, S Salinas, F Bernex, A Bosch, V Kalatzis, T Levade, AM Cuervo, P Lory, A Consiglio, C Brito, EJ Kremer
    Sci Rep, 2018-11-09;8(1):16644.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa
    Authors: A Buskin, L Zhu, V Chichagova, B Basu, S Mozaffari-, D Dolan, A Droop, J Collin, R Bronstein, S Mehrotra, M Farkas, G Hilgen, K White, KT Pan, A Treumann, D Hallam, K Bialas, G Chung, C Mellough, Y Ding, N Krasnogor, S Przyborski, S Zwolinski, J Al-Aama, S Alharthi, Y Xu, G Wheway, K Szymanska, M McKibbin, CF Inglehearn, DJ Elliott, S Lindsay, RR Ali, DH Steel, L Armstrong, E Sernagor, H Urlaub, E Pierce, R Lührmann, SN Grellschei, CA Johnson, M Lako
    Nat Commun, 2018-10-12;9(1):4234.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Natural molecules induce and synergize to boost expression of the human antimicrobial peptide ?-defensin-3
    Authors: E Sechet, E Telford, C Bonamy, PJ Sansonetti, B Sperandio
    Proc. Natl. Acad. Sci. U.S.A., 2018-10-01;0(0):.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  118. 3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling
    Authors: Y Zhang, Y Yang, M Jiang, SX Huang, W Zhang, D Al Alam, S Danopoulos, M Mori, YW Chen, R Balasubram, SM Chuva de S, C Serra, M Bialecka, E Kim, S Lin, ALR Toste de C, PN Riccio, WV Cardoso, X Zhang, HW Snoeck, J Que
    Cell Stem Cell, 2018-09-20;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  119. PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery
    Authors: R Cruz-Acuña, M Quirós, S Huang, D Siuda, JR Spence, A Nusrat, AJ García
    Nat Protoc, 2018-09-01;0(0):.
    Species: Human
    Sample Types: Organoids
    Applications: Bioassay
  120. Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
    Authors: MA Scavuzzo, MC Hill, J Chmielowie, D Yang, J Teaw, K Sheng, Y Kong, M Bettini, C Zong, JF Martin, M Borowiak
    Nat Commun, 2018-08-22;9(1):3356.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Genetically engineered human cortical spheroid models of tuberous sclerosis
    Authors: JD Blair, D Hockemeyer, HS Bateup
    Nat. Med., 2018-08-20;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Self-Renewing Trophoblast Organoids Recapitulate the Developmental Program of the Early Human Placenta
    Authors: S Haider, G Meinhardt, L Saleh, V Kunihs, M Gamperl, U Kaindl, A Ellinger, TR Burkard, C Fiala, J Pollheimer, S Mendjan, PA Latos, M Knöfler
    Stem Cell Reports, 2018-08-02;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  123. Derivation of phenotypically diverse neural culture from hESC by combining adherent and dissociation methods
    Authors: Y Liu, A Antonic, X Yang, N Korte, K Lim, AE Michalska, M Dottori, DW Howells
    J. Neurosci. Methods, 2018-07-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  124. DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis
    Authors: S Chen, L Jia, S Zhang, Y Zheng, Y Zhou
    Stem Cell Res Ther, 2018-07-04;9(1):185.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  125. Sequential Application of Discrete Topographical Patterns Enhances Derivation of Functional Mesencephalic Dopaminergic Neurons from Human Induced Pluripotent Stem Cells
    Authors: KKB Tan, WWM Lim, C Chai, M Kukumberg, KL Lim, ELK Goh, EKF Yim
    Sci Rep, 2018-06-22;8(1):9567.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  126. Random Mutagenesis, Clonal Events, and Embryonic or Somatic Origin Determine the mtDNA Variant Type and Load in Human Pluripotent Stem�Cells
    Authors: F Zambelli, J Mertens, D Dziedzicka, J Sterckx, C Markouli, A Keller, P Tropel, L Jung, S Viville, H Van de Vel, M Geens, S Seneca, K Sermon, C Spits
    Stem Cell Reports, 2018-06-14;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  127. Human Pluripotent Stem-Cell-Derived Cortical Neurons Integrate Functionally into the Lesioned Adult Murine Visual Cortex in an Area-Specific Way
    Authors: I Espuny-Cam, KA Michelsen, D Linaro, A Bilheu, S Acosta-Ver, A Herpoel, M Giugliano, A Gaillard, P Vanderhaeg
    Cell Rep, 2018-05-29;23(9):2732-2743.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  128. Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC
    Authors: J Li, X Wu, Y Zhou, M Lee, L Guo, W Han, W Mo, WM Cao, D Sun, R Xie, Y Huang
    Nucleic Acids Res., 2018-04-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  129. Graphene foam as a biocompatible scaffold for culturing human neurons
    Authors: GM D'Abaco, C Mattei, B Nasr, EJ Hudson, AJ Alshawaf, G Chana, IP Everall, B Nayagam, M Dottori, E Skafidas
    R Soc Open Sci, 2018-03-07;5(3):171364.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  130. Microbiota-Derived Indole Metabolites Promote Human and Murine Intestinal Homeostasis through Regulation of Interleukin-10 Receptor
    Authors: EE Alexeev, JM Lanis, DJ Kao, EL Campbell, CJ Kelly, KD Battista, ME Gerich, BR Jenkins, ST Walk, DJ Kominsky, SP Colgan
    Am. J. Pathol., 2018-02-16;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: Bioassay
  131. Cardiotrophic Growth Factor-Driven Induction of Human Muse Cells Into Cardiomyocyte-Like Phenotype
    Authors: M Amin, Y Kushida, S Wakao, M Kitada, K Tatsumi, M Dezawa
    Cell Transplant, 2018-02-01;27(2):285-298.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  132. Genome-wide analysis of PDX1 target genes in human pancreatic progenitors
    Authors: X Wang, M Sterr, I Burtscher, S Chen, A Hieronimus, F Machicao, H Staiger, HU Häring, G Lederer, T Meitinger, FM Cernilogar, G Schotta, M Irmler, J Beckers, M Hrab? de A, M Ray, CVE Wright, M Bakhti, H Lickert
    Mol Metab, 2018-01-31;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  133. Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1
    Authors: B Memon, M Karam, S Al-Khawaga, EM Abdelalim
    Stem Cell Res Ther, 2018-01-23;9(1):15.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  134. BMP/SMAD pathway promotes neurogenesis of midbrain dopaminergic neurons in vivo and in human induced pluripotent and neural stem cells
    Authors: VM Jovanovic, A Salti, H Tilleman, K Zega, MM Jukic, H Zou, RH Friedel, N Prakash, S Blaess, F Edenhofer, C Brodski
    J. Neurosci., 2018-01-10;0(0):.
    Species: Human
    Sample Types:
  135. Identification of direct negative crosstalk between the SLIT2 and Bone Morphogenetic Protein-Gremlin signaling pathways
    Authors: KE Tumelty, N Higginson-, X Fan, P Bajaj, KM Knowlton, M Shamashkin, AJ Coyle, W Lu, SP Berasi
    J. Biol. Chem., 2018-01-09;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  136. Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips.
    Authors: Michael J Workman, John P Gleeson, Elissa J Troisi, Hannah Q Estrada, S Jordan Kerns, Christopher D Hinojosa, Geraldine A Hamilton, Stephan R Targan, Clive N Svendsen, Robert J Barrett
    Cellular and Molecular Gastroenterology and Hepatology, 2017-12-29;0(0):2352-345X.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  137. Directly Converted Human Fibroblasts Mature to Neurons and Show Long-Term Survival in Adult Rodent Hippocampus
    Authors: N Avaliani, U Pfisterer, A Heuer, M Parmar, M Kokaia, M Andersson
    Stem Cells Int, 2017-11-26;2017(0):5718608.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  138. Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming
    Authors: T Ruetz, U Pfisterer, B Di Stefano, J Ashmore, M Beniazza, TV Tian, DF Kaemena, L Tosti, W Tan, JR Manning, E Chantzoura, DR Ottosson, S Collombet, A Johnsson, E Cohen, K Yusa, S Linnarsson, T Graf, M Parmar, K Kaji
    Cell Stem Cell, 2017-11-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  139. TRAIL attenuates RANKL-mediated osteoblastic signalling in vascular cell mono-culture and co-culture models
    Authors: E Harper, KD Rochfort, H Forde, C Davenport, D Smith, PM Cummins
    PLoS ONE, 2017-11-16;12(11):e0188192.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  140. A right-handed signalling pathway drives heart looping in vertebrates
    Authors: OH Ocaña, H Coskun, C Minguillón, P Murawala, EM Tanaka, J Galcerán, R Muñoz-Cháp, MA Nieto
    Nature, 2017-09-06;549(7670):86-90.
    Species: Zebrafish
    Sample Types: Whole Tissue
    Applications: Bioassay
  141. Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors
    Authors: KF Cogger, A Sinha, F Sarangi, EC McGaugh, D Saunders, C Dorrell, S Mejia-Guer, Y Aghazadeh, JL Rourke, RA Screaton, M Grompe, PR Streeter, AC Powers, M Brissova, T Kislinger, MC Nostro
    Nat Commun, 2017-08-24;8(1):331.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  142. Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation
    Authors: SV Hegarty, SL Wyatt, L Howard, E Stappers, D Huylebroec, AM Sullivan, GW O'Keeffe
    Sci Rep, 2017-08-17;7(1):8568.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  143. A pluripotent stem cell-based model for post-implantation human amniotic sac development
    Authors: Y Shao, K Taniguchi, RF Townshend, T Miki, DL Gumucio, J Fu
    Nat Commun, 2017-08-08;8(1):208.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  144. REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways
    Authors: J Drouin-Oue, S Lau, PL Brattås, D Rylander O, K Pircs, DA Grassi, LM Collins, R Vuono, A Andersson, G Westergren, C Graff, L Minthon, H Toresson, RA Barker, J Jakobsson, M Parmar
    EMBO Mol Med, 2017-08-01;9(8):1117-1131.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  145. Differentiation of Human Pluripotent Stem Cells into Colonic Organoids via Transient Activation of BMP Signaling
    Authors: JO Múnera, N Sundaram, SA Rankin, D Hill, C Watson, M Mahe, JE Vallance, NF Shroyer, KL Sinagoga, A Zarzoso-La, JR Hudson, JC Howell, P Chatuvedi, JR Spence, JM Shannon, AM Zorn, MA Helmrath, JM Wells
    Cell Stem Cell, 2017-06-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  146. Establishment of a refined culture method for rat colon organoids
    Authors: H Isshiki, Y Arimura, K Nagaishi, K Kawakami, K Onodera, K Yamashita, Y Naishiro, M Fujimiya, K Imai, Y Shinomura
    Biochem. Biophys. Res. Commun., 2017-05-27;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  147. Common genetic variation drives molecular heterogeneity in human iPSCs
    Authors: H Kilpinen, A Goncalves, A Leha, V Afzal, K Alasoo, S Ashford, S Bala, D Bensaddek, FP Casale, OJ Culley, P Danecek, A Faulconbri, PW Harrison, A Kathuria, D McCarthy, SA McCarthy, R Meleckyte, Y Memari, N Moens, F Soares, A Mann, I Streeter, CA Agu, A Alderton, R Nelson, S Harper, M Patel, A White, SR Patel, L Clarke, R Halai, CM Kirton, A Kolb-Kokoc, P Beales, E Birney, D Danovi, AI Lamond, WH Ouwehand, L Vallier, FM Watt, R Durbin, O Stegle, DJ Gaffney
    Nature, 2017-05-10;546(7658):370-375.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  148. Epigenetic and transcriptional modulation of WDR5, a chromatin remodeling protein, in Huntington's disease human induced pluripotent stem cell (hiPSC) model
    Authors: S Baronchell, A La Spada, A Ntai, A Barbieri, P Conforti, GS Jotti, S Redaelli, A Bentivegna, P De Blasio, I Biunno
    Mol. Cell. Neurosci., 2017-05-02;82(0):46-57.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  149. Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells
    Authors: E Raja, A Komuro, R Tanabe, S Sakai, Y Ino, N Saito, T Todo, M Morikawa, H Aburatani, D Koinuma, C Iwata, K Miyazono
    Oncogene, 2017-05-01;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  150. A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model
    Authors: X Yuan, Z Li, AC Baines, E Gavriilaki, Z Ye, Z Wen, EM Braunstein, LG Biesecker, L Cheng, X Dong, RA Brodsky
    PLoS ONE, 2017-04-25;12(4):e0174074.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  151. Melanoma-Derived iPCCs Show Differential Tumorigenicity and Therapy Response
    Authors: M Bernhardt, D Novak, Y Assenov, E Orouji, N Knappe, K Weina, M Reith, L Larribere, C Gebhardt, C Plass, V Umansky, J Utikal
    Stem Cell Reports, 2017-04-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  152. Differentiation of oligodendrocyte progenitor cells from dissociated monolayer and feeder-free cultured pluripotent stem cells
    Authors: T Yamashita, Y Miyamoto, Y Bando, T Ono, S Kobayashi, A Doi, T Araki, Y Kato, T Shirakawa, Y Suzuki, J Yamauchi, S Yoshida, N Sato
    PLoS ONE, 2017-02-13;12(2):e0171947.
    Species: Primate
    Sample Types: Whole Cells
    Applications: Bioassay
  153. Species-specific developmental timing is maintained by pluripotent stem cells ex utero
    Authors: C Barry, MT Schmitz, P Jiang, MP Schwartz, BM Duffin, S Swanson, R Bacher, JM Bolin, AL Elwell, BE McIntosh, R Stewart, JA Thomson
    Dev. Biol., 2017-02-06;423(2):101-110.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation, Differentiation
  154. Wnt/?-catenin promotes gastric fundus specification in mice and humans
    Authors: KW McCracken, E Aihara, B Martin, CM Crawford, T Broda, J Treguier, X Zhang, JM Shannon, MH Montrose, JM Wells
    Nature, 2017-01-04;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  155. Reductive carboxylation is a major metabolic pathway in the retinal pigment epithelium
    Proc. Natl. Acad. Sci. U.S.A., 2016-12-01;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  156. BMP4/Id2 signaling pathway is a novel therapeutic target for late outgrowth endothelial progenitor cell-mediated endothelial injury repair
    Authors: Jun Tao
    Int. J. Cardiol., 2016-11-09;228(0):796-804.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  157. Remyelination Is Correlated with Regulatory T Cell Induction Following Human Embryoid Body-Derived Neural Precursor Cell Transplantation in a Viral Model of Multiple Sclerosis
    Authors: Warren C Plaisted
    PLoS ONE, 2016-06-16;11(6):e0157620.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  158. Growth hormone is permissive for neoplastic colon growth
    Proc Natl Acad Sci USA, 2016-05-25;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  159. Altered neuronal network and rescue in a human MECP2 duplication model
    Mol. Psychiatry, 2015-09-08;21(2):178-88.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  160. DNA methylation directs functional maturation of pancreatic beta cells.
    Authors: Dhawan S, Tschen S, Zeng C, Guo T, Hebrok M, Matveyenko A, Bhushan A
    J Clin Invest, 2015-06-22;125(7):2851-60.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  161. TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors.
    Authors: Cebola I, Rodriguez-Segui S, Cho C, Bessa J, Rovira M, Luengo M, Chhatriwala M, Berry A, Ponsa-Cobas J, Maestro M, Jennings R, Pasquali L, Moran I, Castro N, Hanley N, Gomez-Skarmeta J, Vallier L, Ferrer J
    Nat Cell Biol, 2015-04-27;17(5):615-26.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  162. In vitro generation of human pluripotent stem cell derived lung organoids.
    Authors: Dye, Briana R, Hill, David R, Ferguson, Michael, Tsai, Yu-Hwai, Nagy, Melinda, Dyal, Rachel, Wells, James M, Mayhew, Christop, Nattiv, Roy, Klein, Ophir D, White, Eric S, Deutsch, Gail H, Spence, Jason R
    Elife, 2015-03-24;4(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  163. Analysing human neural stem cell ontogeny by consecutive isolation of Notch active neural progenitors.
    Authors: Edri, Reuven, Yaffe, Yakey, Ziller, Michael, Mutukula, Naresh, Volkman, Rotem, David, Eyal, Jacob-Hirsch, Jasmine, Malcov, Hagar, Levy, Carmit, Rechavi, Gideon, Gat-Viks, Irit, Meissner, Alexande, Elkabetz, Yechiel
    Nat Commun, 2015-03-23;6(0):6500.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  164. Resveratrol ameliorates the maturation process of beta-cell-like cells obtained from an optimized differentiation protocol of human embryonic stem cells.
    Authors: Pezzolla D, Lopez-Beas J, Lachaud C, Dominguez-Rodriguez A, Smani T, Hmadcha A, Soria B
    PLoS ONE, 2015-03-16;10(3):e0119904.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  165. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells.
    Authors: Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D'Souza S, Snoeck H
    Nat Protoc, 2015-02-05;10(3):413-25.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  166. A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face.
    Authors: Hu D, Young N, Li X, Xu Y, Hallgrimsson B, Marcucio R
    Development, 2015-02-01;142(3):567-74.
    Species: Chicken
    Sample Types: Whole Organism
    Applications: In Vivo
  167. Early intervention for spinal cord injury with human induced pluripotent stem cells oligodendrocyte progenitors.
    Authors: All A, Gharibani P, Gupta S, Bazley F, Pashai N, Chou B, Shah S, Resar L, Cheng L, Gearhart J, Kerr C
    PLoS ONE, 2015-01-30;10(1):e0116933.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  168. Selective lentiviral gene delivery to CD133-expressing human glioblastoma stem cells.
    Authors: Bayin, N Sumru, Modrek, Aram S, Dietrich, August, Lebowitz, Jonathan, Abel, Tobias, Song, Hae-Ri, Schober, Markus, Zagzag, David, Buchholz, Christia, Chao, Moses V, Placantonakis, Dimitris
    PLoS ONE, 2014-12-26;9(12):e116114.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  169. SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma.
    Authors: Hernanda P, Chen K, Das A, Sideras K, Wang W, Li J, Cao W, Bots S, Kodach L, de Man R, Ijzermans J, Janssen H, Stubbs A, Sprengers D, Bruno M, Metselaar H, ten Hagen T, Kwekkeboom J, Peppelenbosch M, Pan Q
    Oncogene, 2014-12-22;34(39):5055-68.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  170. Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function.
    Authors: Leslie J, Huang S, Opp J, Nagy M, Kobayashi M, Young V, Spence J
    Infect Immun, 2014-10-13;83(1):138-45.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  171. Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain.
    Authors: Pereira, Maria, Pfisterer, Ulrich, Rylander, Daniella, Torper, Olof, Lau, Shong, Lundblad, Martin, Grealish, Shane, Parmar, Malin
    Sci Rep, 2014-09-11;4(0):6330.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  172. Dual small-molecule targeting of SMAD signaling stimulates human induced pluripotent stem cells toward neural lineages.
    Authors: Wattanapanitch M, Klincumhom N, Potirat P, Amornpisutt R, Lorthongpanich C, U-pratya Y, Laowtammathron C, Kheolamai P, Poungvarin N, Issaragrisil S
    PLoS ONE, 2014-09-10;9(9):e106952.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  173. Real-time discrimination between proliferation and neuronal and astroglial differentiation of human neural stem cells.
    Authors: Lee, Rimi, Kim, Il-Sun, Han, Nalae, Yun, Seokhwan, Park, Kook In, Yoo, Kyung-Hw
    Sci Rep, 2014-09-10;4(0):6319.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  174. Optimal effector functions in human natural killer cells rely upon autocrine bone morphogenetic protein signaling.
    Authors: Robson N, Hidalgo L, McAlpine T, Wei H, Martinez V, Entrena A, Melen G, MacDonald A, Phythian-Adams A, Sacedon R, Maraskovsky E, Cebon J, Ramirez M, Vicente A, Varas A
    Cancer Res, 2014-07-18;74(18):5019-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  175. A multiplex high-throughput gene expression assay to simultaneously detect disease and functional markers in induced pluripotent stem cell-derived retinal pigment epithelium.
    Authors: Ferrer M, Corneo B, Davis J, Wan Q, Miyagishima K, King R, Maminishkis A, Marugan J, Sharma R, Shure M, Temple S, Miller S, Bharti K
    Stem Cells Transl Med, 2014-05-29;3(8):911-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  176. Polycomb group protein expression during differentiation of human embryonic stem cells into pancreatic lineage in vitro.
    Authors: Pethe, Prasad, Nagvenkar, Punam, Bhartiya, Deepa
    BMC Cell Biol, 2014-05-24;15(0):18.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  177. Retinoic acid signalling regulates the development of tonotopically patterned hair cells in the chicken cochlea.
    Authors: Thiede B, Mann Z, Chang W, Ku Y, Son Y, Lovett M, Kelley M, Corwin J
    Nat Commun, 2014-05-20;5(0):3840.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: Bioassay
  178. A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear.
    Authors: Mann Z, Thiede B, Chang W, Shin J, May-Simera H, Lovett M, Corwin J, Kelley M
    Nat Commun, 2014-05-20;5(0):3839.
    Species: Chicken
    Sample Types: Whole Cells
    Applications: Bioassay
  179. The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro.
    Authors: Ali F, Cheng K, Kirwan P, Metcalfe S, Livesey F, Barker R, Philpott A
    Development, 2014-05-12;141(11):2216-24.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  180. CEP290 gene transfer rescues Leber congenital amaurosis cellular phenotype.
    Authors: Burnight E, Wiley L, Drack A, Braun T, Anfinson K, Kaalberg E, Halder J, Affatigato L, Mullins R, Stone E, Tucker B
    Gene Ther, 2014-05-08;21(7):662-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  181. Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide.
    Authors: He Q, Wang G, Wakade S, Dasgupta S, Dinkins M, Kong J, Spassieva S, Bieberich E
    Mol Biol Cell, 2014-04-02;25(11):1715-29.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  182. Defined human pluripotent stem cell culture enables highly efficient neuroepithelium derivation without small molecule inhibitors.
    Authors: Lippmann E, Estevez-Silva M, Ashton R
    Stem Cells, 2014-04-01;32(4):1032-42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  183. Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture.
    Authors: Takeuchi, Hiroki, Nakatsuji, Norio, Suemori, Hirofumi
    Sci Rep, 2014-03-27;4(0):4488.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  184. Neuroprotection by rAAV-mediated gene transfer of bone morphogenic protein 7.
    Authors: Heinonen A, Rahman M, Dogbevia G, Jakobi H, Wolfl S, Sprengel R, Schwaninger M
    BMC Neurosci, 2014-03-11;15(0):38.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  185. Inner ear hair cell-like cells from human embryonic stem cells.
    Authors: Ronaghi, Mohammad, Nasr, Marjan, Ealy, Megan, Durruthy-Durruthy, Robert, Waldhaus, Joerg, Diaz, Giovanni, Joubert, Lydia-Ma, Oshima, Kazuo, Heller, Stefan
    Stem Cells Dev, 2014-03-10;23(11):1275-84.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  186. Prospectively isolated NGN3-expressing progenitors from human embryonic stem cells give rise to pancreatic endocrine cells.
    Authors: Cai, Qing, Bonfanti, Paola, Sambathkumar, Rangaraj, Vanuytsel, Kim, Vanhove, Jolien, Gysemans, Conny, Debiec-Rychter, Maria, Raitano, Susanna, Heimberg, Harry, Ordovas, Laura, Verfaillie, Catherin
    Stem Cells Transl Med, 2014-02-03;3(4):489-99.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  187. Influence of in vitro and in vivo oxygen modulation on beta cell differentiation from human embryonic stem cells.
    Authors: Cechin S, Alvarez-Cubela S, Giraldo J, Molano R, Villate S, Ricordi C, Pileggi A, Inverardi L, Fraker C, Dominguez-Bendala J
    Stem Cells Transl Med, 2013-12-27;3(3):277-89.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  188. Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers.
    Authors: Lam A, Freedman B, Morizane R, Lerou P, Valerius M, Bonventre J
    J Am Soc Nephrol, 2013-12-19;25(6):1211-25.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  189. A synthetic peptide-acrylate surface for production of insulin-producing cells from human embryonic stem cells.
    Authors: Lin P, Hung S, Yang Y, Liao L, Hsieh Y, Yen H, Lu H, Lee M, Chu I, Hwang S
    Stem Cells Dev, 2013-11-16;23(4):372-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  190. Recessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis.
    Authors: Weedon M, Cebola I, Patch A, Flanagan S, De Franco E, Caswell R, Rodriguez-Segui S, Shaw-Smith C, Cho C, Lango Allen H, Houghton J, Roth C, Chen R, Hussain K, Marsh P, Vallier L, Murray A, Ellard S, Ferrer J, Hattersley A
    Nat Genet, 2013-11-10;46(1):61-4.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  191. Inhibition of bone morphogenic protein 4 restores endothelial function in db/db diabetic mice.
    Authors: Zhang Y, Liu J, Tian X, Wong W, Chen Y, Wang L, Luo J, Cheang W, Lau C, Kwan K, Wang N, Yao X, Huang Y
    Arterioscler Thromb Vasc Biol, 2013-11-07;34(1):152-9.
    Species: Mouse
    Sample Types: Whole Organism, Whole Tissue
    Applications: Bioassay, In Vivo
  192. Enrichment of human embryonic stem cell-derived NKX6.1-expressing pancreatic progenitor cells accelerates the maturation of insulin-secreting cells in vivo.
    Authors: Rezania A, Bruin J, Xu J, Narayan K, Fox J, O'Neil J, Kieffer T
    Stem Cells, 2013-11-01;31(11):2432-42.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  193. Bone morphogenetic protein 2 signaling negatively modulates lymphatic development in vertebrate embryos.
    Authors: Dunworth, William, Cardona-Costa, Jose, Bozkulak, Esra Cag, Kim, Jun-Dae, Meadows, Stryder, Fischer, Johanna, Wang, Yeqi, Cleaver, Ondine, Qyang, Yibing, Ober, Elke A, Jin, Suk-Won
    Circ Res, 2013-10-11;114(1):56-66.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  194. Generation of multipotent foregut stem cells from human pluripotent stem cells.
    Authors: Hannan, Nicholas, Fordham, Robert P, Syed, Yasir A, Moignard, Victoria, Berry, Andrew, Bautista, Ruben, Hanley, Neil A, Jensen, Kim B, Vallier, Ludovic
    Stem Cell Reports, 2013-10-10;1(4):293-306.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  195. Bone morphogenetic protein-2/-4 upregulation promoted by endothelial cells in coculture enhances mouse embryoid body differentiation.
    Authors: Talavera-Adame, Dodanim, Gupta, Ankur, Kurtovic, Silvia, Chaiboonma, Kira L, Arumugaswami, Vaithili, Dafoe, Donald C
    Stem Cells Dev, 2013-09-24;22(24):3252-60.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  196. Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa.
    Authors: Tucker, Budd A, Mullins, Robert F, Streb, Luan M, Anfinson, Kristin, Eyestone, Mari E, Kaalberg, Emily, Riker, Megan J, Drack, Arlene V, Braun, Terry A, Stone, Edwin M
    Elife, 2013-08-27;2(0):e00824.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  197. Translating dosage compensation to trisomy 21.
    Authors: Jiang J, Jing Y, Cost G, Chiang J, Kolpa H, Cotton A, Carone D, Carone B, Shivak D, Guschin D, Pearl J, Rebar E, Byron M, Gregory P, Brown C, Urnov F, Hall L, Lawrence J
    Nature, 2013-07-17;500(7462):296-300.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  198. Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.
    Authors: Maroof A, Keros S, Tyson J, Ying S, Ganat Y, Merkle F, Liu B, Goulburn A, Stanley E, Elefanty A, Widmer H, Eggan K, Goldstein P, Anderson S, Studer L
    Cell Stem Cell, 2013-05-02;12(5):559-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  199. Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium.
    Authors: Buchholz, David E, Pennington, Britney, Croze, Roxanne, Hinman, Cassidy, Coffey, Peter J, Clegg, Dennis O
    Stem Cells Transl Med, 2013-04-18;2(5):384-93.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  200. Activation of the type I interferon pathway is enhanced in response to human neuronal differentiation.
    Authors: Farmer, Jocelyn, Altschaefl, Kate M, O'Shea, K Sue, Miller, David J
    PLoS ONE, 2013-03-07;8(3):e58813.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  201. Use of a synthetic xeno-free culture substrate for induced pluripotent stem cell induction and retinal differentiation.
    Authors: Tucker B, Anfinson K, Mullins R, Stone E, Young M
    Stem Cells Transl Med, 2012-12-27;2(1):16-24.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  202. Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.
    Authors: Brafman D, Phung C, Kumar N, Willert K
    Cell Death Differ, 2012-11-16;20(3):369-81.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  203. Interplay between electrical activity and bone morphogenetic protein signaling regulates spinal neuron differentiation.
    Authors: Swapna, Immani, Borodinsky, Laura N
    Proc Natl Acad Sci U S A, 2012-09-18;109(40):16336-41.
    Species: Xenopus
    Sample Types: Whole Tissue
    Applications: Bioassay
  204. Cited2 gene controls pluripotency and cardiomyocyte differentiation of murine embryonic stem cells through Oct4 gene.
    Authors: Li Q, Ramirez-Bergeron D, Dunwoodie S, Yang Y
    J Biol Chem, 2012-07-03;287(34):29088-100.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  205. Downregulation of hemojuvelin prevents inhibitory effects of bone morphogenetic proteins on iron metabolism in hepatocellular carcinoma.
    Authors: Maegdefrau U, Arndt S, Kivorski G, Hellerbrand C, Bosserhoff AK
    Lab. Invest., 2011-08-22;91(11):1615-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  206. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro.
    Authors: Spence JR, Mayhew CN, Rankin SA
    Nature, 2010-12-12;470(7332):105-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  207. A defined glycosaminoglycan-binding substratum for human pluripotent stem cells.
    Authors: Klim JR, Li L, Wrighton PJ
    Nat. Methods, 2010-11-14;7(12):989-94.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. What is the half life of Recombinant Human Noggin Protein (Catalog # 6057-NG) in vitro?

    • Recombinant Human Noggin Protein (Catalog # 6057-NG) is evaluated for bioactivity by its ability to inhibit BMP-4-induced alkaline phosphatase production in mouse chondrogenic cells in vitro. We have not evaluated the half-life of 6057-NG.  The half-life of a specific protein will depend on experimental conditions, including the cell number, density, and media content. It is up to the end-users to determine the appropriate concentration and timing when adding 6057-NG to individual experiments. For techniques and methodologies, we recommend reviewing our list of publications under the Citations tab on the product-specific web page to find reported use of our products in similar experimental layouts.

  2. Has Recombinant Human Noggin Protein (Catalog # 6057-NG or 6057-NG/CF) been evaluated in vivo?

    • Recombinant Human Noggin Protein (Catalog # 6057-NG) is evaluated for bioactivity by its ability to inhibit BMP-4-induced alkaline phosphatase production in mouse chondrogenic cells in vitro. We have not evaluated this protein for activity in vivo, but we are aware of publications citing use of the protein this type of experimentation. We recommend reviewing our list of publications under the Citations tab on the product-specific web page to find reported use of our products in similar experimental layouts.

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Reviews for Recombinant Human Noggin Protein

Average Rating: 4.4 (Based on 9 Reviews)

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Recombinant Human Noggin Protein
By Mona Agrawal on 10/11/2023
Application: Stem/Immune cell maintenance or differentiation
Stem/Immune cell maintenance or differentiation Recombinant Human Noggin Protein 6057-NG
Recombinant Human Noggin Protein
By Anonymous on 09/26/2021
Application: Stem/Immune cell maintenance or differentiation

Used for iPSC differentiation into intestinal organoids at a concentration of 100ng/mL

Recombinant Human Noggin Protein
By Ermali Aliaj on 01/02/2021
Application: Cell Culture
Recombinant Human Noggin Protein
By Anonymous on 12/28/2020
Application: CellProlif
Reason for Rating: Cells grew well.
Cell Proliferation Recombinant Human Noggin Protein 6057-NG
Recombinant Human Noggin Protein
By Anonymous on 04/05/2019
Application: Stem/Immune cell maintenance or differentiation
Recombinant Human Noggin Protein
By Anonymous on 12/22/2017
Application: Cell Culture

combination of a low dose of Noggin and the bone morphogenetic protein

Recombinant Human Noggin Protein
By Anonymous on 04/25/2017
Recombinant Human Noggin Protein
By Anonymous on 01/04/2017
Application: Stem/Immune cell maintenance or differentiation
Stem/Immune cell maintenance or differentiation Recombinant Human Noggin Protein 6057-NG
Recombinant Human Noggin Protein
By Anonymous on 10/26/2015

Noggin (100 ng/ml) was added into DMEM/F12 (plus B27 and N2) medium to promote neurogenesis of human-induced pluripotent stem cells.

Recombinant Human Noggin Protein 6057-NG