Rat μ Opioid R/OPRM1 Antibody

Catalog #: MAB8629
1 Citation Datasheet / COA / SDS

Recombinant Monoclonal Antibody

Catalog #	Availability	Size / Price	Qty
MAB8629
MAB8629-SP

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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Rat μ Opioid R/OPRM1 Antibody Summary

Specificity

Detects rat μ Opioid R/OPRM1 in direct ELISAs.

Source

Recombinant Monoclonal Rabbit IgG Clone # 1126B

Purification

Protein A or G purified from cell culture supernatant

Immunogen

Synthetic peptide with a short amino acid sequence from the N-terminus of rat μ Opioid R/OPRM1
Accession # P33535

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Immunohistochemistry

1-25 µg/mL

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry

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μ Opioid R/OPRM1 in Rat Spinal Cord. µ Opioid R/OPRM1 was detected in perfusion fixed frozen sections of rat spinal cord using Rabbit Anti-Rat µ Opioid R/OPRM1 Monoclonal Antibody (Catalog # MAB8629) at 1 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Rabbit IgG Secondary Antibody (red; Catalog # NL004) and counterstained with DAPI (blue). Specific staining was localized to dorsal horn. View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: mu Opioid R/OPRM1

The mu-type opioid receptor (MOR), also known as OPRM1, is a 60‑70 kDa variably glycosylated G protein-coupled receptor that mediates the biological effects of many alkaloid and peptide opioids including morphine. MOR is primarily expressed on neurons in the brain, spinal cord, and gastrointestinal tract as well as on immune cells. MOR activation induces analgesia, euphoria, sedation, respiratory depression, and reduced intestinal motility. Following agonist binding, MOR is phosphorylated and internalized which contributes to opioid tolerance and desensitization. OPRM1 can form heterdimers with several other 7TM GPCRs including the delta-type Opioid Receptor (DOR), Nociceptin/Orphanin Receptor (ORL1), Neurokinin 1 Receptor (NK1), Somatostatin Receptor 2 (SSTR2), Cannabinoid Receptor 1, CCR5, and the alpha 2A-Adrenergic Receptor (ADRA2A). Rat MOR shares 94% and 98% aa sequence identity with human and mouse MOR, respectively.

Long Name

mu Opioid Receptor

Entrez Gene IDs

4988 (Human); 18390 (Mouse); 25601 (Rat)

Alternate Names

hMOP; KIAA0403; LMOR; MOP; mOpioidR; MOR; MOR1; M-OR-1; MOR-1; MOR1MOR; Mu opiate receptor; mu Opioid R; Mu opioid receptor; mu-type opioid receptor; opioid receptor, mu 1; OPRM; OPRM1

Product Datasheets

Product Datasheet

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Related Research Areas

Citation for Rat μ Opioid R/OPRM1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1