Rat μ Opioid R/OPRM1 Antibody
Rat μ Opioid R/OPRM1 Antibody Summary
Accession # P33535
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
![µ Opioid R/OPRM1 antibody in Rat Spinal Cord by Immunohistochemistry (IHC-Fr). µ Opioid R/OPRM1 antibody in Rat Spinal Cord by Immunohistochemistry (IHC-Fr).](https://aeroglobalimagesuat.blob.core.windows.net/images/datasheets/antibody/mu_Opioid_R_MAB8629_Immunohistochemistry_16797.jpg)
μ Opioid R/OPRM1 in Rat Spinal Cord. µ Opioid R/OPRM1 was detected in perfusion fixed frozen sections of rat spinal cord using Rabbit Anti-Rat µ Opioid R/OPRM1 Monoclonal Antibody (Catalog # MAB8629) at 1 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Rabbit IgG Secondary Antibody (red; Catalog # NL004) and counterstained with DAPI (blue). Specific staining was localized to dorsal horn. View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: mu Opioid R/OPRM1
The mu-type opioid receptor (MOR), also known as OPRM1, is a 60‑70 kDa variably glycosylated G protein-coupled receptor that mediates the biological effects of many alkaloid and peptide opioids including morphine. MOR is primarily expressed on neurons in the brain, spinal cord, and gastrointestinal tract as well as on immune cells. MOR activation induces analgesia, euphoria, sedation, respiratory depression, and reduced intestinal motility. Following agonist binding, MOR is phosphorylated and internalized which contributes to opioid tolerance and desensitization. OPRM1 can form heterdimers with several other 7TM GPCRs including the delta-type Opioid Receptor (DOR), Nociceptin/Orphanin Receptor (ORL1), Neurokinin 1 Receptor (NK1), Somatostatin Receptor 2 (SSTR2), Cannabinoid Receptor 1, CCR5, and the alpha 2A-Adrenergic Receptor (ADRA2A). Rat MOR shares 94% and 98% aa sequence identity with human and mouse MOR, respectively.
Product Datasheets
Citation for Rat μ Opioid R/OPRM1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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Methadone Requires the Co-Activation of ?-Opioid and Toll-Like-4 Receptors to Produce Extracellular DNA Traps in Bone-Marrow-Derived Mast Cells
Authors: Martínez-Cuevas, FL;Cruz, SL;González-Espinosa, C;
International journal of molecular sciences
Species: Murine polyomavirus strain A3
Sample Types: Whole Cells
Applications: Immunocytochemistry
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