(R)-CE3F4
Chemical Name: (2R)-5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde
Purity: ≥98%
Biological Activity
(R)-CE3F4 is an Epac inhibitor (IC50 values are 4.2 and 44 μM for Epac1 and Epac2(B), respectively). Blocks activation of Epac by cAMP. This is the R-enantiomer of CE3F4 (Cat.No.4793).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Mechanism of selective enzyme inhibition through uncompetitive regulation of an allosteric agonist.
Boulton et al.
J.Am.Chem.Soc., 2018;140:9624 -
The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1).
Courilleau et al.
Biochem.Biophys.Res.Commun., 2013;440:443
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