CE3F4
Chemical Name: 5,7-Dibromo-6-fluoro-3,4-dihydro-2-methyl-1(2H)-quinolinecarboxaldehyde
Purity: ≥98%
Biological Activity
CE3F4 is a noncompetitive Epac1 inhibitor. Blocks Epac-induced Rap activation and prevents isoprenaline-induced autophagy flux in cardiomyocytes. Has no effect on PKA activity in the presence of cAMP.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy.
Laurent Ac, Bisserier M, Lucas A et al.
Cardiovasc. Res. -
Identification of a tetrahydroquinoline analog as a pharmacological inhibitor of the cAMP-binding protein Epac.
Courilleau et al.
J.Biol.Chem., 2012;287:44192
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Citations for CE3F4
The citations listed below are publications that use Tocris products. Selected citations for CE3F4 include:
4 Citations: Showing 1 - 4
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The peripheral Epac1/p-Cav-1 pathway underlies the disruption of the vascular endothelial barrier following skin/muscle incision and retraction-induced chronic postsurgical pain.
Authors: Chen Et al.
Ann.Trans.Med. 2022;10:1377
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Regulation of Mitochondrial Function by Epac2 Contributes to Acute Inflammatory Hyperalgesia.
Authors: Derek C Et al.
J Neurosci 2021;41:2883-2898
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Inhibition of IRF4 in dendritic cells by PRR-independent and -dependent signals inhibit Th2 and promote Th17 responses.
Authors: Paul A Et al.
Elife 2020;9
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Soluble adenylyl cyclase-mediated cAMP signaling and the putative role of PKA and EPAC in cerebral mitochondrial function.
Authors: Jakobsen Et al.
J Neurosci Res 2019;97:1018
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