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Phosphoramidon disodium salt

Catalog #: 6333
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Phosphoramidon disodium salt | CAS No. 164204-38-0 | Additional Synthetic Protease Inhibitors
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Description: Neutral endopeptidase and endothelin converting enzyme inhibitor

Chemical Name: N-[N-[[(6-Deoxy-α-L-mannopyranosyl)oxy]hydroxyphosphinyl]-L-leucyl]-L-tryptophan disodium salt

Purity: ≥95%

Product Details
Citations (1)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Phosphoramidon disodium salt is a neutral endopeptidase (neprilysin) inhibitor. Blocks degradation of amyloid β peptides and increases Aβ levels in rodents. Also blocks endothelin converting enzyme (ECE).

Technical Data

M.Wt:
587.47
Formula:
C23H32N3Na2O10P
Solubility:
Soluble to 100 mM in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
164204-38-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Crystal structures of human procathepsin H
    Y Hao, W Purtha, C Cortesio, H Rui, Y Gu, H Chen, EA Sickmier, P Manzanillo, X Huang
    PLoS ONE, 2018;13(7):e0200374.
  2. Amyloid-beta and Alzheimer's disease: the role of neprilysin-2 in amyloid-beta clearance.
    Marr and Hafez
    Front.Aging Neurosci., 2014;6:187
  3. Neprilysin degrades both amyloid β peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases.
    Shirotani et al.
    J.Biol.Chem., 2001;276:21895
  4. Regional differences in endothelin converting enzyme activity in rat brain: inhibition by phosphoramidon and EDTA.
    Warner et al.
    Br.J.Pharmacol., 1992;106:948

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Citation for Phosphoramidon disodium salt

The citations listed below are publications that use Tocris products. Selected citations for Phosphoramidon disodium salt include:

1 Citation: Showing 1 - 1

  1. Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.
    Authors: Bruce L Et al.
    Mol Neurodegener  2021;16:51

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