Pepstatin A

Catalog # Availability Size / Price Qty
1190/10
Pepstatin A
1 Image
Description: Selective and high affinity cathepsin D inhibitor

Purity: ≥95%

Product Details
Citations (3)
Reviews (1)

Biological Activity

Pepstatin A is an irreversible inhibitor of aspartic proteases. Inhibits lysosomal proteases and interferes with autolysosomal digestion when used in combination with E 64d (Cat. No. 4545).

Technical Data

M.Wt:
685.91
Formula:
C34H63N5O9
Sequence:
VVXAX

(Modifications: Val-1 = N-terminal iso-Valeryl, X-3 = X-5 = Sta)

Solubility:
Soluble to 1 mg/ml in ethanol with gentle warming
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
26305-03-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-?1
    P Tripathi, N Rodriguez-, JR Klim, AS de Boer, S Agrawal, J Sandoe, CS Lopes, KS Ogliari, LA Williams, M Shear, LL Rubin, K Eggan, Q Zhou
    Stem Cell Reports, 2017;0(0):.
  2. An autocrine/paracrine circuit of growth differentiation factor (GDF) 15 has a role for maintenance of breast cancer stem-like cells
    A Sasahara, K Tominaga, T Nishimura, M Yano, E Kiyokawa, M Noguchi, M Noguchi, H Kanauchi, T Ogawa, H Minato, K Tada, Y Seto, A Tojo, N Gotoh
    Oncotarget, 2017;8(15):24869-24881.
  3. Autophagy is activated in colorectal cancer cells and contributes to the tolerance to nutrient deprivation.
    Sato et al.
    Cancer Res., 2007;67:9677
  4. Mode of inhibition of acid proteases by pepstatin.
    Marciniszyn et al.
    J.Biol.Chem., 1976;251:7088

Product Datasheets

Or select another batch:
View Batch
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Pepstatin A

The citations listed below are publications that use Tocris products. Selected citations for Pepstatin A include:

3 Citations: Showing 1 - 3

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Reviews for Pepstatin A

Average Rating: 4 (Based on 1 Review)

5 Star
0%
4 Star
50%
3 Star
0%
2 Star
0%
1 Star
0%

Have you used Pepstatin A?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


Protease Inhibitor
By Reetu Singh on 03/08/2021
Species: Human

use this as a protease inhibitor in my protein isolation buffer. It was a beneficial product for the Rat profiling cytokine assay kit.


Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.