Mouse TREM-1 APC-conjugated Antibody Summary
Ala21-Ser202
Accession # Q9JKE2
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of TREM‑1 in Mouse Splenocytes by Flow Cytometry. Mouse splenocytes were stained with Rat Anti-Mouse Gr-1/Ly-6G Alexa Fluor® 405-conjugated Monoclonal Antibody (Catalog # FAB1037V) and either (A) Rat Anti-Mouse TREM-1 APC-conjugated Monoclonal Antibody (Catalog # FAB1187A) or (B) Rat IgG2AAllophycocyanin Isotype Control (Catalog # IC006A). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TREM-1
TREM-1 (Triggering Receptor Expressed on Myeloid cells) is a type I transmembrane protein having a single Ig-like domain. It associates with the adapter protein, DAP12, to deliver an activating signal. Several other TREM family members have been reported that are structurally similar but share less than 30% amino acid identity. TREM-1 is expressed on blood neutrophils and a subset of monocytes, and expression is up-regulated by bacterial LPS. Engagement of TREM-1 with a monoclonal antibody leads to expression of IL-8, MCP-1, and TNF-alpha suggesting that this receptor plays an important role in inflammatory responses. TREM-1 is expressed at high levels on neutrophils of patients with microbial sepsis and in mice with LPS-induced shock. Blockade of TREM-1 with a TREM-1/Fc fusion protein protected mice against LPS-induced shock.
- Bouchon, A. (2000) J. Immunol. 164:4991.
- Bouchon, A. (2001) Nature 410:1103.
- Nathan, C. and A. Ding (2001) Nature Med. 7:530.
Product Datasheets
Citations for Mouse TREM-1 APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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TREM-1 is required for enhanced OpZ-induced superoxide generation following priming
Authors: S Murthy, S Baruah, JL Bowen, K Keck, BA Wagner, GR Buettner, DB Sykes, J Klesney-Ta
Journal of leukocyte biology, 2022-01-24;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Extracellular CIRP as an endogenous TREM-1 ligand to fuel inflammation in sepsis
Authors: NL Denning, M Aziz, A Murao, SD Gurien, M Ochani, JM Prince, P Wang
JCI Insight, 2020-03-12;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry, ICC -
TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance.
Authors: Weber B, Schuster S, Zysset D, Rihs S, Dickgreber N, Schurch C, Riether C, Siegrist M, Schneider C, Pawelski H, Gurzeler U, Ziltener P, Genitsch V, Tacchini-Cottier F, Ochsenbein A, Hofstetter W, Kopf M, Kaufmann T, Oxenius A, Reith W, Saurer L, Mueller C
PLoS Pathog, 2014-01-16;10(1):e1003900.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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