Mouse sFRP-2 Antibody Summary
Leu25-Cys295
Accession # P97299
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: sFRP-2
Secreted Frizzled Related Proteins (sFRPs) are a family of vertebrate proteins which contain homology to the ligand-binding domain of the Frizzled family of transmembrane receptors. The sFRPs are approximately 30-35 kDa in size and are comprised of 3 domains: a signal sequence; a cysteine-rich domain (CRD) of about 110 amino acids (aa) with a high degree of similarity to the Frizzled proteins, including 10 conserved cysteines, and a 175 aa conserved hydrophilic carboxy terminal region. Because sFRPs contain a CRD very similar to the region responsible for binding Wnt ligands in Frizzleds, sFRPS are thought to act as soluble antagonists of Wnt signals. sFRP-2, also known as SARP-1, SDF-5, and FRP-2, is expressed during mouse embryogenesis in the eye, brain, neural tube, craniofacial mesenchyme, joints, testis, pancreas, kidney, and regions of smooth muscle cell development. Expression in the adult animal has been detected in the eye, heart, lung, along with preadipose and adipose tissues in mice and humans. Mouse and human sFRP-2 proteins share 98% aa identity, and related proteins have also been identified in chick, rabbit, and frog. A variety of activities have been reported for sFRP-2 including an increased resistance to apoptosis, antagonism of Xwnt -8 signaling in Xenopus, regulation of Wnt-4 signaling (with sFRP-1) in renal organogenesis, and inhibition of the migration of glioma cells (1-7).
- Rattner, A. et al. (1997) Proc. Natl. Acad. Sci. USA 94:2859.
- Melkonyan, H. et al. (1997) Proc. Natl. Acad. Sci. USA 94:13636.
- Hu, E. et al. (1998) BBRC 247:287.
- Leimeister, C. et al. (1998) Mech. Dev. 75:29.
- Roth, W. et al. (2000) Oncogene 19:4210.
- Ladher, R. et al. (2000) Dev. Biol. 218:183.
- Yoshino, K. et al. (2001) Mech. Dev. 102:45.
Product Datasheets
Citations for Mouse sFRP-2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Activation of adult mammalian retinal stem cells in vivo via antagonism of BMP and sFRP2
Authors: Kenneth N. Grisé, Brenda L. K. Coles, Nelson X. Bautista, Derek van der Kooy
Stem Cell Research & Therapy
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Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice
Authors: E Forte, DA Skelly, M Chen, S Daigle, KA Morelli, O Hon, VM Philip, MW Costa, NA Rosenthal, MB Furtado
Cell Rep, 2020-03-03;30(9):3149-3163.e6.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC
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