Home / SCGF/CLEC11a / Mouse SCGF/CLEC11a Antibody

Mouse SCGF/CLEC11a Antibody

Catalog #: AF3729
7 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF3729
AF3729-SP
Product Details
Citations (7)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Mouse SCGF/CLEC11a Antibody Summary

Species Reactivity
Mouse
Specificity
Detects mouse SCGF/CLEC11a in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 2% cross-reactivity with recombinant human SCGF is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse SCGF/CLEC11a
Ala22-Phe328
Accession # O88200
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Mouse SCGF/CLEC11a

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: SCGF/CLEC11a

SCGF, also named CLEC11a, is a 47 kDa, 328 amino acid, secreted glycoprotein member of the C-type lectin superfamily. Produced by CD33+ stem cells and resting chondrocytes, SCGF acts in combination with other factors to promote erythroid, myeloid and endothelial cell production. Over the region used as immunogen, mouse SCGF is 92% and 83% aa identical to the corresponding rat and human protein sequences, respectively.

Long Name
Stem Cell Growth Factor/C-type Lectin Domain Family 11, Member A
Entrez Gene IDs
6320 (Human); 20256 (Mouse); 29313 (Rat)
Alternate Names
CLEC11a; CLECSF3; LSLCL; P47; SCGF

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Citations for Mouse SCGF/CLEC11a Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

7 Citations: Showing 1 - 7
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  1. The effect of parathyroid hormone on osteogenesis is mediated partly by osteolectin
    Authors: Zhang J, Cohen A, Shen B et al.
    Proceedings of the National Academy of Sciences of the United States of America
  2. A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise
    Authors: Stephen Gadomski, Claire Fielding, Andrés García-García, Claudia Korn, Chrysa Kapeni, Sadaf Ashraf et al.
    Cell Stem Cell
  3. Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target
    Authors: H Wei, Y Xu, Y Wang, L Xu, C Mo, L Li, B Shen, Y Sun, P Cheng, L Yang, Y Pang, A Qin, Y Cao, SJ Morrison, R Yue
    Cell Rep, 2020-10-13;33(2):108252.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  4. Chronic activation of endothelial MAPK disrupts hematopoiesis via NFKB dependent inflammatory stress reversible by SCGF
    Authors: P Ramalingam, MG Poulos, E Lazzari, MC Gutkin, D Lopez, CC Kloss, MJ Crowley, L Katsnelson, AG Freire, MB Greenblatt, CY Park, JM Butler
    Nat Commun, 2020-02-03;11(1):666.
    Species: Mouse
    Sample Types: Plasma
    Applications: ELISA (detection)
  5. Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism
    Authors: Y Hu, Y Zhang, CY Ni, CY Chen, SS Rao, H Yin, J Huang, YJ Tan, ZX Wang, J Cao, ZZ Liu, PL Xie, B Wu, J Luo, H Xie
    Theranostics, 2020-01-16;10(5):2293-2308.
    Species: Mouse
    Sample Types: Cell Culture Lysates
    Applications: Western Blot
  6. Inhibition of fibroblast activation protein ameliorates cartilage matrix degradation and osteoarthritis progression
    Authors: Aoyuan Fan, Genbin Wu, Jianfang Wang, Laiya Lu, Jingyi Wang, Hanjing Wei et al.
    Bone Research
  7. Integrin alpha11 is an Osteolectin receptor and is required for the maintenance of adult skeletal bone mass
    Authors: Bo Shen, Kristy Vardy, Payton Hughes, Alpaslan Tasdogan, Zhiyu Zhao, Rui Yue et al.
    eLife

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