Mouse IL-15R alpha Biotinylated Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Background: IL-15R alpha
Interleukin 15 receptor alpha (IL-15 R alpha ) is a high affinity receptor that specifically binds IL-15 with high affinity and associates as a heterotrimer with the IL-2 receptors beta and gamma subunits to initiate signal transduction. IL-15 R alpha is expressed on a wide variety of T cells and B cells as well as non-lymphoid cells. IL-15 R alpha is a 58-60 kDa protein that shares structural similarities to the IL-2 R alpha protein. IL-15 R alpha and IL-2 R alpha genes also share similar intron-exon organization and are closely linked on human chromosome 10p14-p15. Human IL-15 R alpha shares 45% amino acid (aa) homology with the mouse form of the receptor. Signaling of IL-15 can occur in one of three ways; through the heterotrimeric complex of IL-15 R alpha, IL-2 R beta, and IL-2 R gamma c, through the heterodimeric complex of IL-2 receptors beta and gamma common, through a novel 60-65 kDa IL-15 RX subunit found on mast cells. The binding of IL-15 to IL-15 R alpha has been reported to antagonize the TNF-alpha -mediated apoptosis in fibroblasts by competing with TNF RI for TRAF2 binding.
- Anderson, D.M. et al. (1995) J. Biol. Chem. 270:29862.
- Bulfone-Paus, S. et al. (1999) FASEB 13:1575.
- Waldemann, T.A. and Y. Tagaya (1999) Ann. Rev. Immunol. 17:19.
- Dubois, S. et al. (1999) J. Biol. Chem. 274:26978.
Product Datasheets
Citations for Mouse IL-15R alpha Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity
Authors: N Simonovi?, A Witalisz-S, K Meissl, C Lassnig, U Reichart, T Kolbe, M Farlik, C Bock, V Sexl, M Müller, B Strobl
J. Immunol., 2019-02-04;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia
Cell Biosci, 2016-05-06;6(0):30.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-15 receptor alpha signaling constrains the development of IL-17-producing gammadelta T cells.
Authors: Colpitts S, Puddington L, Lefrancois L
Proc Natl Acad Sci U S A, 2015-07-20;112(31):9692-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Different NK cell developmental events require different levels of IL-15 trans-presentation.
Authors: Lee GA, Liou YH, Wang SW, Ko KL, Jiang ST, Liao NS
J. Immunol., 2011-06-29;187(3):1212-21.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15R alpha.
Authors: Sato N, Sabzevari H, Fu S, Ju W, Petrus MN, Bamford RN, Waldmann TA, Tagaya Y
Blood, 2011-02-08;117(15):4032-40.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity.
Authors: Sikora AG, Jaffarzad N, Hailemichael Y, Gelbard A, Stonier SW, Schluns KS, Frasca L, Lou Y, Liu C, Andersson HA, Hwu P, Overwijk WW
J. Immunol., 2009-06-15;182(12):7398-407.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer.
Authors: Zhang M, Yao Z, Dubois S, Ju W, Muller JR, Waldmann TA
Proc. Natl. Acad. Sci. U.S.A., 2009-04-21;106(18):7513-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Inhibition of tumor growth by NK1.1+ cells and CD8+ T cells activated by IL-15 through receptor beta/common gamma signaling in trans.
Authors: Rowley J, Monie A, Hung CF, Wu TC
J. Immunol., 2008-12-15;181(12):8237-47.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-2, -7, and -15, but not thymic stromal lymphopoeitin, redundantly govern CD4+Foxp3+ regulatory T cell development.
Authors: Vang KB, Yang J, Mahmud SA, Burchill MA, Vegoe AL, Farrar MA
J. Immunol., 2008-09-01;181(5):3285-90.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response.
Authors: Rubinstein MP, Lind NA, Purton JF, Filippou P, Best JA, McGhee PA, Surh CD, Goldrath AW
Blood, 2008-08-08;112(9):3704-12.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
A synaptic basis for paracrine interleukin-2 signaling during homotypic T cell interaction.
Authors: Sabatos CA, Doh J, Chakravarti S, Friedman RS, Pandurangi PG, Tooley AJ, Krummel MF
Immunity, 2008-07-31;29(2):238-48.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
Regulatory T cells control dendritic cell/NK cell cross-talk in lymph nodes at the steady state by inhibiting CD4+ self-reactive T cells.
Authors: Terme M, Chaput N, Combadiere B, Ma A, Ohteki T, Zitvogel L
J. Immunol., 2008-04-01;180(7):4679-86.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-15 does not affect IEL development in the thymus but regulates homeostasis of putative precursors and mature CD8 alpha alpha+ IELs in the intestine.
Authors: Lai YG, Hou MS, Hsu YW, Chang CL, Liou YH, Tsai MH, Lee F, Liao NS
J. Immunol., 2008-03-15;180(6):3757-65.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Antigen controls IL-7Ralpha expression levels on CD8 T cells during full activation or tolerance induction.
Authors: Hammerbeck CD, Mescher MF
J. Immunol., 2008-02-15;180(4):2107-16.
Species: Mouse
Sample Types: Whole Cells
Applications: Functional Assay -
DAP12 signaling directly augments proproliferative cytokine stimulation of NK cells during viral infections.
Authors: French AR, Sjolin H, Kim S, Koka R, Yang L, Young DA, Cerboni C, Tomasello E, Ma A, Vivier E, Karre K, Yokoyama WM
J. Immunol., 2006-10-15;177(8):4981-90.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Distinct modulatory effects of LPS and CpG on IL-18-dependent IFN-gamma synthesis.
Authors: Gould MP, Greene JA, Bhoj V, DeVecchio JL, Heinzel FP
J. Immunol., 2004-02-01;172(3):1754-62.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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