Mouse GDF-7/BMP-12 Biotinylated Antibody

Catalog #: BAF779 Datasheet / COA / SDS

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BAF779

All GDF-7/BMP-12 Antibodies

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Mouse GDF-7/BMP-12 Biotinylated Antibody Summary

Species Reactivity

Mouse

Specificity

Detects mouse GDF‑7/BMP‑12 in Western blots. In Western blots, approximately 10% cross‑reactivity with recombinant mouse (rm) GDF-5 and rmGDF-6 is observed and less than 1% cross-reactivity with rmGDF-1, rmGDF-3, rmGDF-8, rmGDF-9, and recombinant human GDF-11 is observed.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant mouse GDF‑7/BMP‑12
Thr316-Arg461
Accession # P43029

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Label

Biotin

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Mouse GDF‑7/BMP‑12 (Catalog # 779-G7)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: GDF-7/BMP-12

Growth Differentiation Factor 7 (GDF-7), also known as bone morphogenetic protein (BMP) 12 or cartilage derived morphogenetic protein 3 (CDMP-3), is a member of the bone morphogenetic protein (BMP) family which belongs to the transforming growth factor beta (TGF-beta ) superfamily. Mature GDF-7 contains 146 aa residues with the characteristic seven conserved cysteine residues. The bioactive GDF-7 is a homodimer with an apparent molecular weight of approximately 28 kDa. Mature GDF-5, GDF-6 and GDF-7, which share 80‑86% identity with each other, define a new subgroup within the BMP family. Like other TGF-beta superfamily proteins, GDF-7 is highly conserved across species. At the amino acid sequence level, mature human and mouse GDF-7 are 98% identical. It has been reported that GDF-7 has multiple functions including regulation of chondrogenesis, bone morphogenesis, and neuron differentiation. GDF-7 response is mediated by the formation of hetero-oligomeric complexes of type I (BMPR-IB) and type II (BMPR-II or Activin R-II) sereine/threonine kinase receptors, and the activiation of Smad proteins.

References

Storm, E.E., et al. (1994) Nature 368:639.
Nishitoh, H., et al. (1996) J. Biol. Chem. 271:21345.
Francis-West, P.H., et al. (1999) Development 126:1035.
Massague, J. et al. (2000) Genes and Dev. 14:627.

Long Name

Growth Differentiation Factor 7

Entrez Gene IDs

151449 (Human); 238057 (Mouse)

Alternate Names

BMP12; BMP-12; GDF7; GDF-7; growth differentiation factor 7; growth/differentiation factor 7

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Product Datasheet

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