m-3M3FBS
Chemical Name: 2,4,6-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
Purity: ≥98%
Biological Activity
m-3M3FBS is an activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate formation in a variety of cell types. Also inhibits growth of the leukemic cell lines U937 and THP-1.Negative Control also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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The Complement System Component C5a Produces Thermal Hyperalgesia via Macrophage-to-Nociceptor Signaling That Requires NGF and TRPV1
J Neurosci, 2016;36(18):5055-70. -
Phosphatidylinositol 3,4-bisphosphate regulates neurite initiation and dendrite morphogenesis via actin aggregation
SX Zhang, LH Duan, SJ He, GF Zhuang, X Yu
Cell Res, 2017;0(0):. -
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Lee G, Subramanian N, Kim A, Aksentijevich I, Goldbach-Mansky R, Sacks D, Germain R, Kastner D, Chae J
Nature, 2012;492(7427):123-7. -
Identification of a compound that directly stimulates phospholipase C activity.
Bae et al.
Mol.Pharmacol., 2003;63:1043 -
The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis.
Lee et al.
Cancer Lett., 2005;222:227 -
Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation.
Krjukova et al.
Br.J.Pharmacol., 2004;143:3
Product Datasheets
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Citations for m-3M3FBS
The citations listed below are publications that use Tocris products. Selected citations for m-3M3FBS include:
7 Citations: Showing 1 - 7
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IPIP27 Coordinates PtdIns(4,5)P2 Homeostasis for Successful Cytokinesis.
Authors: Carim Et al.
Curr Biol 2019;29:775
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TMEM203 Is a Novel Regulator of Intracellular Calcium Homeostasis and Is Required for Spermatogenesis.
Authors: Shambharkar Et al.
PLoS One 2015;10:e0127480
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DA Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation.
Authors: Rioult-Pedotti Et al.
J Gen Physiol 2015;10:e0124986
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Activation of phospholipase C mimics the phase shifting effects of light on melatonin rhythms in retinal photoreceptors.
Authors: Semple-Rowland Et al.
PLoS One 2014;8:e83378
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Calcium release-dependent actin flow in the leading process mediates axophilic migration.
Authors: Hutchins Et al.
PLoS One 2013;33:11361
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High extracellular Ca2+ stimulates Ca2+-activated Cl- currents in frog parathyroid cells through the mediation of arachidonic acid cascade.
Authors: Okada Et al.
PLoS One 2011;6:e19158
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Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation.
Authors: Krjukova Et al.
Br J Pharmacol 2004;143:3
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