Human ULBP-1 PerCP-conjugated Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of ULBP‑1 in Jurkat Human Cell Line by Flow Cytometry. Jurkat human acute T cell leukemia cell line was stained with Mouse Anti-Human ULBP-1 PerCP-conjugated Monoclonal Antibody (Catalog # FAB1380C, filled histogram) or isotype control antibody (Catalog # IC003C, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Detection of ULBP‑1 in Molt-4 Human Cell Line by Flow Cytometry. Molt-4 human myeloid leukemia cell line was stained with Mouse Anti-Human ULBP-1 PerCP-conjugated Monoclonal Antibody (Catalog # FAB1380C, filled histogram) or isotype control antibody (IC003C, open histogram). Staining was performed using our Staining Membrane-associated Proteins protocol.
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Detection of Human ULBP-1 by Flow Cytometry Histograms showing sample flow cytometry profiles for the ligands studied. Bars in each plot indicate the population expressing each aNKR, Gates were set using Unstained, single stained controls, fluorescence minus one, and secondary antibody alone controls. Image collected and cropped by CiteAb from the following publication (https://www.mdpi.com/1999-4915/9/10/295), licensed under a CC-BY license. Not internally tested by R&D Systems.
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Preparation and Storage
Background: ULBP-1
ULBP-1 is a member of a family of cell-surface proteins that function as ligands for human NKG2D. ULBP-1 has also been described under the names RaeT1I (retinoic acid early transcript), ALCAN-beta, and NKG2DL1. The name ULBP-1 derives from the original identification of three proteins, ULBP-1, -2, and -3, as ligands for the human cytomegalovirus glycoprotein UL16; they were designated UL16 binding proteins (ULBP). The gene for ULBP-1 resides in a cluster of ten related genes, six of which encode potentially functional glycoproteins. Amino acid sequence identity within this family ranges from 30-95%. These proteins are distantly related to MHC class I proteins, but they possess only the alpha 1 and alpha 2 Ig-like domains, and they have no capacity to bind peptide or interact with beta 2-microglobulin. They are anchored to the membrane via a GPI-linkage. ULBP-1 and several other family members are known to bind to human NKG2D, an activating receptor expressed on NK cells, NKT cells, gamma δ T cells, and CD8+ alpha beta T cells. Engagement of NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. ULBP-1 is expressed on some tumor cells and has been implicated in tumor surveillance (1-8).
- Cosman, D. et al. (2001) Immunity 14:123.
- Kubin, M. et al. (2001) Eur. J. Immunol. 31:1428.
- Sutherland, C. et al. (2002) J. Immunol. 168:671.
- Steinle, A. et al. (2001) Immunogenetics 53:279.
- Sutherland, C. et al. (2001) Immunol. Rev. 181:185
- Pende, D. et al. (2002) Cancer Res. 62:6178.
- Radosavljevic, M. et al. (2002) Genomics 79:114
- NKG2D and its Ligands, 2002; www.RnDSystems.com.
Product Datasheets
Citations for Human ULBP-1 PerCP-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 8
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NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer
Authors: Bérengère Salomé, John P. Sfakianos, Daniel Ranti, Jorge Daza, Christine Bieber, Andrew Charap et al.
Cancer Cell
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Targeting WEE1/AKT restores p53-dependent NK cell activation to induce immune checkpoint blockade responses in 'cold' melanoma
Authors: SS Dinavahi, YC Chen, K Punnath, A Berg, M Herlyn, M Foroutan, ND Huntington, GP Robertson
Cancer Immunology Research, 2022-06-03;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: FACS -
Identification of HIV-reservoir cells with reduced susceptibility to antibody-dependent immune response
Authors: Antonio Astorga-Gamaza, Judith Grau-Expósito, Joaquín Burgos, Jordi Navarro, Adrià Curran, Bibiana Planas et al.
eLife
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Genetic and Molecular Basis of Heterogeneous NK Cell Responses against Acute Leukemia
Authors: DR Makanga, F Da Rin de, G David, C Willem, L Dubreuil, N Legrand, T Guillaume, P Peterlin, A Lebourgeoi, MC Béné, A Garnier, P Chevallier, K Gendzekhad, A Cesbron, K Gagne, B Clemenceau, C Retière
Cancers (Basel), 2020-07-16;12(7):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Histone Deacetylase Inhibitor Modulates NKG2D Receptor Expression and Memory Phenotype of Human Gamma/Delta T Cells Upon Interaction With Tumor Cells
Authors: Jaydeep Bhat, Samuel Dubin, Alexandra Dananberg, Elgar Susanne Quabius, Juergen Fritsch, C. Marie Dowds et al.
Frontiers in Immunology
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Expression of ligands for activating natural killer cell receptors on cell lines commonly used to assess natural killer cell function
Authors: A Tremblay-M, S Coenraads, Z Kiani, FP Dupuy, NF Bernard
BMC Immunol., 2019-01-29;20(1):8.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Overcoming Target Driven Fratricide for T Cell Therapy
Authors: Eytan Breman, Benjamin Demoulin, Sophie Agaugué, Sebastien Mauën, Alexandre Michaux, Lorraine Springuel et al.
Frontiers in Immunology
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Expression Profiles of Ligands for Activating Natural Killer Cell Receptors on HIV Infected and Uninfected CD4? T Cells
Authors: A Tremblay-M, J Bruneau, B Lebouché, I Lisovsky, R Song, NF Bernard
Viruses, 2017-10-12;9(10):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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