Human ULBP-1 APC-conjugated Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of ULBP‑1 in MOLT‑4 Human Cell Line by Flow Cytometry. MOLT-4 human acute lymphoblastic leukemia cell line was stained with Mouse Anti-Human ULBP-1 APC-conjugated Monoclonal Antibody (Catalog # FAB1380A, filled histogram) or isotype control antibody (Catalog # IC003A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: ULBP-1
ULBP-1 is a member of a family of cell-surface proteins that function as ligands for human NKG2D. ULBP-1 has also been described under the names RaeT1I (Retinoic Acid Early Transcript), ALCAN-beta, and NKG2DL1. The name ULBP-1 derives from the original identification of three proteins, ULBP-1, -2, and -3, as ligands for the human cytomegalovirus glycoprotein UL16; they were designated UL16 Binding Proteins (ULBP). The gene for ULBP-1 resides in a cluster of ten related genes, six of which encode potentially functional glycoproteins. Amino acid sequence identity within this family ranges from 30-95%. These proteins are distantly related to MHC class I proteins, but they possess only the alpha 1 and alpha 2 Ig-like domains, and they have no capacity to bind peptide or interact with beta 2-microglobulin. They are anchored to the membrane via a GPI-linkage. ULBP-1 and several other family members are known to bind to human NKG2D, an activating receptor expressed on NK cells, NKT cells, gamma δ T cells, and CD8+ alpha beta T cells. Engagement of NKG2D results in the activation of cytolytic activity and/or cytokine production by these effector cells. ULBP-1 is expressed on some tumor cells and has been implicated in tumor surveillance (1-8).
- Cosman, D. et al. (2001) Immunity 14:123.
- Kubin, M. et al. (2001) Eur. J. Immunol. 31:1428.
- Sutherland, C. et al. (2002) J. Immunol. 168:671.
- Steinle, A. et al. (2001) Immunogenetics 53:279.
- Sutherland, C. et al. (2001) Immunol. Rev. 181:185
- Pende, D. et al. (2002) Cancer Res. 62:6178.
- Radosavljevic, M. et al. (2002) Genomics 79:114
- NKG2D and its Ligands, 2002; www.RnDSystems.com.
Product Datasheets
Citations for Human ULBP-1 APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 5
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Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance
Authors: Dario Gerace, Quan Zhou, Jennifer Hyoje-Ryu Kenty, Adrian Veres, Elad Sintov, Xi Wang et al.
Cell Reports Medicine
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Natural killer cell therapy potentially enhances the antitumor effects of bevacizumab plus irinotecan in a glioblastoma mouse model
Authors: Thi-Anh-Thuy Tran, Young-Hee Kim, Thi-Hoang-Oanh Duong, JayaLakshmi Thangaraj, Tan-Huy Chu, Shin Jung et al.
Frontiers in Immunology
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Engineering of immune checkpoints B7-H3 and CD155 enhances immune compatibility of MHC-I-/- iPSCs for beta cell replacement
Authors: R Chimienti, T Baccega, S Torchio, F Manenti, S Pellegrini, A Cospito, A Amabile, MT Lombardo, P Monti, V Sordi, A Lombardo, M Malnati, L Piemonti
Cell Reports, 2022-09-27;40(13):111423.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
The diterpenoid adenanthin upregulates the expression of natural killer group 2D receptor ligands in hepatocellular carcinoma cells
Authors: X Zhong, H Liao, S Hu, K Luo, H Zhu
Molecular and cellular probes, 2021-07-12;59(0):101759.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Complete Remission with Reduction of High-risk Clones following Haploidentical NK Cell Therapy against MDS and AML
Authors: AT Björklund, M Carlsten, E Sohlberg, LL Liu, T Clancy, M Karimi, S Cooley, JS Miller, M Klimkowska, M Schaffer, E Watz, KI Wikstrom, P Blomberg, BE Wahlin, M Palma, L Hansson, P Ljungman, E Hellström-, HG Ljunggren, KJ Malmberg
Clin. Cancer Res., 2018-02-14;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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the ligand for NKG2D. we used this antibody to analyze the expression of ULBP1 in CD4 T Cells.
