Human Serpin A9/Centerin Antibody

Catalog #: MAB5429 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB5429
MAB5429-SP

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Human Serpin A9/Centerin Antibody Summary

Species Reactivity

Human

Specificity

Detects human Serpin A9/Centerin in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human Serpin A1, A3, A4, A5, A6, A11, A12, B6, B8, B9, C1, D1, E1, E2, F1, F2, G1, I1, I2, recombinant mouse (rm) SerpinA3N, and rmSerpinA9 is observed.

Source

Monoclonal Mouse IgG_2A Clone # 585302

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Serpin A9/Centerin
Ala24-Thr417
Accession # AAQ89063

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Immunohistochemistry

8-25 µg/mL

Immersion-fixed paraffin-embedded sections of human B cell lymphoma

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Serpin A9/Centerin

Serpin A9 (Serine proteinase inhibitor-clade A #9; also GCET1, Centerin and Serpin A11) is a 46 kDa, secreted member of the alpha 1-antitrypsin (clade A) subfamily, serpin superfamily of protease inhibitors. It is only produced by normal and lymphoma germinal center B cells. Its function is unknown, but it presumably acts as an inhibitor of a trypsin-like protease. Mature human Serpin A9 is presumably 394 amino acids (aa) in length. It contains one Serpin motif (aa 405-415). There are multiple splice variants associated with Serpin A9. There are alternate start sites at Met19, Met99 and Met150. A fourth isoform shows a two aa substitution for aa 369-435, while a fifth isoform shares this same substitution coupled with a 39 aa substitution for aa 1-75. A sixth variant shows a deletion of aa 91-190. Mature human Serpin A9 shares 67% aa identity with mouse Serpin A9.

Long Name

Serpin Peptidase Inhibitor, Clade A, Member 9

Entrez Gene IDs

327657 (Human); 71907 (Mouse); 299274 (Rat)

Alternate Names

Centerin; GCET1; Serpin A9; SERPINA11; SERPINA11b

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

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