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Human/Rat CCR4 Fluorescein-conjugated Antibody

Catalog #: FAB1567F
14 Citations Datasheet / COA / SDS
Clone 205410 was used by HLDA to establish CD designation
Catalog # Availability Size / Price Qty
FAB1567F-025
FAB1567F-100
Detection of CCR4 in Human Blood Lymphocytes by Flow Cytometry.
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Citations (14)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Rat CCR4 Fluorescein-conjugated Antibody Summary

Species Reactivity
Human, Rat
Specificity
Stains human CCR4-transfected cell lines but not the corresponding parent cell lines. Also detects human CCR4 on human PBLs and platelets and rat CCR4 on rat splenocytes.
Source
Monoclonal Mouse IgG2B Clone # 205410
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Human CCR4 transfectants
Met1-Leu360
Accession # P51679
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Fluorescein (Excitation= 488 nm, Emission= 515-545 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of CCR4 antibody in Human Blood Lymphocytes antibody by Flow Cytometry. View Larger

Detection of CCR4 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human/Rat CCR4 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB1567F) and Mouse Anti-Human CD3e APC-conjugated Monoclonal Antibody (Catalog # FAB100A). Quadrant markers were set based on control antibody staining (Catalog # IC0041F). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: CCR4

CCR4 is a G protein-linked seven transmembrane domain chemokine receptor that binds the chemokines CCL17/TARC and CCL22/MDC. Current evidence suggests that CCR4 expression is associated with Th-2 type T cells and with platelets. CCR4 expression has also been reported in mature dendritic cells.

Entrez Gene IDs
1233 (Human); 12773 (Mouse); 171054 (Rat); 403541 (Canine); 102120178 (Cynomolgus Monkey)
Alternate Names
C-C chemokine receptor type 4; C-C CKR-4; CC-CKR-4HGCN:14099; CCR4; CCR-4; CD194 antigen; CD194; chemokine (C-C motif) receptor 4; chemokine (C-C) receptor 4; ChemR13; CKR4MGC88293; CMKBR4k5-5; K5-5

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Citations for Human/Rat CCR4 Fluorescein-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

14 Citations: Showing 1 - 10
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  1. Bispecific human IL2‐CCR4 immunotoxin targets human cutaneous T‐cell lymphoma
    Authors: Haoyu Wang, Zhaohui Wang, Huiping Zhang, Zeng Qi, Ariel C. Johnson, David Mathes et al.
    Molecular Oncology
  2. Treg depletion in non-human primates using a novel diphtheria toxin-based anti-human CCR4 immunotoxin
    Authors: Zhaohui Wang, Shannon G. Pratts, Huiping Zhang, Philip J. Spencer, Ruichao Yu, Makoto Tonsho et al.
    Molecular Oncology
  3. CCR4-IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T-cell lymphoma in a mouse CTCL model
    Authors: Wang, Z;Ma, J;Zhang, H;Ramakrishna, R;Mintzlaff, D;Mathes, DW;Pomfret, EA;Lucia, MS;Gao, D;Haverkos, BM;Wang, Z;
    FEBS open bio
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. Natural Killer Cells from Allergic Donors Are Defective in Their Response to CCL18 Chemokine
    Authors: L Amniai, C Ple, M Barrier, P de Nadai, P Marquillie, H Vorng, C Chenivesse, A Tsicopoulo, C Duez
    International Journal of Molecular Sciences, 2021-04-09;22(8):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. Histone deacetylase inhibitors downregulate CCR4 expression and decrease mogamulizumab efficacy in CCR4-positive mature T-cell lymphomas
    Authors: A Kitadate, S Ikeda, F Abe, N Takahashi, N Shimizu, K Matsue, H Tagawa
    Haematologica, 2017-10-12;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin
    Authors: Zhirui Wang
    Vet. Immunol. Immunopathol., 2016-10-29;182(0):150-158.
    Species: Porcine
    Sample Types: Whole Blood
    Applications: Flow Cytometry
  7. Glatiramer Acetate, Dimethyl Fumarate, and Monomethyl Fumarate Upregulate the Expression of CCR10 on the Surface of Natural Killer Cells and Enhance Their Chemotaxis and Cytotoxicity
    Authors: Zaidoon Al-Jaderi
    Front Immunol, 2016-10-19;7(0):437.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  8. Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome.
    Authors: James E, Gates T, LaFond R, Yamamoto S, Ni C, Mai D, Gersuk V, O'Brien K, Nguyen Q, Zeitner B, Lanteri M, Norris P, Chaussabel D, Malhotra U, Kwok W
    PLoS Pathog, 2016-01-21;12(1):e1005375.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  9. Identification of human NK17/NK1 cells.
    Authors: Pandya AD, Al-Jaderi Z, Hoglund RA, Holmoy T, Harbo HF, Norgauer J, Maghazachi AA
    PLoS ONE, 2011-10-21;6(10):e26780.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver.
    Authors: Oo YH, Weston CJ, Lalor PF, Curbishley SM, Withers DR, Reynolds GM, Shetty S, Harki J, Shaw JC, Eksteen B, Hubscher SG, Walker LS, Adams DH
    J. Immunol., 2010-02-17;184(6):2886-98.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  11. Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression.
    Authors: Brucklacher-Waldert V, Steinbach K, Lioznov M, Kolster M, Holscher C, Tolosa E
    J. Immunol., 2009-11-01;183(9):5494-501.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  12. Homeostatic regulation of T effector to Treg ratios in an area of seasonal malaria transmission.
    Authors: Finney OC, Nwakanma D, Conway DJ, Walther M, Riley EM
    Eur. J. Immunol., 2009-05-01;39(5):1288-300.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  13. CCR4-expressing T cell tumors can be specifically controlled via delivery of toxins to chemokine receptors.
    Authors: Baatar D, Olkhanud P, Newton D, Sumitomo K, Biragyn A
    J. Immunol., 2007-08-01;179(3):1996-2004.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  14. Chemokine receptor expression on allergen-specific T cells in asthma and allergic bronchopulmonary aspergillosis.
    Authors: Garcia G, Humbert M, Capel F, Rimaniol AC, Escourrou P, Emilie D, Godot V
    Allergy, 2007-02-01;62(2):170-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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