Human Plexin B1 Antibody Summary
Leu35-Val150
Accession # O43157
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Plexin B1
Plexin B1 is a type I transmembrane protein that belongs to the Plexin family of semaphorin receptors. It is derived from a single peptide that undergoes proteolytic processing in its extracellular domain to form the non-covalently-linked heterodimer of the extracellular alpha subunit and the transmembrane beta subunit. Human Plexin B1 extracellular alpha subunit shares homology with semaphorins, HGF receptor and MSP receptor and contains a sema domain and three IPT/TIG domains. It functions as a receptor for semaphorin 4D/CD100. Multiple splice isoforms of Plexin B1 have been reported. Within the region used as immunogen, human Plexin B1 shares 90% and 97% amino acid sequence homology with mouse and canine Plexin B1, respectively.
Product Datasheets
Citations for Human Plexin B1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 6
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Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics
Authors: Yong Huang, Rut Tejero, Vivian K. Lee, Concetta Brusco, Theodore Hannah, Taylor B. Bertucci et al.
Communications Biology
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The IkappaB kinase complex is required for plexin-B-mediated activation of RhoA.
Authors: Zielonka M, Krishnan R, Swiercz J, Offermanns S
PLoS ONE, 2014-08-19;9(8):e105661.
Species: Human
Sample Types: Cell Lysates
Applications: Immunoprecipitation -
Grb2 mediates semaphorin-4D-dependent RhoA inactivation.
Authors: Sun, Tianlian, Krishnan, Rameshku, Swiercz, Jakub M
J Cell Sci, 2012-04-14;125(0):3557-67.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
ErbB-2 signals through Plexin-B1 to promote breast cancer metastasis.
Authors: Worzfeld T, Swiercz JM, Looso M
J. Clin. Invest., 2012-03-01;122(4):1296-305.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
ErbB-2 and met reciprocally regulate cellular signaling via plexin-B1.
Authors: Swiercz JM, Worzfeld T, Offermanns S
J. Biol. Chem., 2007-11-19;283(4):1893-901.
Species: Human
Sample Types: Cell Lysates
Applications: Immunoprecipitation, Western Blot -
A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib
Authors: Tianliang Sun
J. Cell Biol, 2016-12-22;0(0):.
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