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Human OAS2 Antibody

Catalog #: MAB1925
2 Citations 1 Review Datasheet / COA / SDS
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MAB1925
MAB1925-SP
OAS2 in U266 Human Cell Line.
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Citations (2)
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Reviews (1)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human OAS2 Antibody Summary

Species Reactivity
Human
Specificity
Detects human OAS2.
Source
Monoclonal Mouse IgG2a Clone # HLS56/3
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. See Certificate of Analysis for details.
*Small pack size (-SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Immunoprecipitation
Hovanessian, A.G. et al. (1987) EMBO J. 6:1273.
 
Immunocytochemistry
3-25 µg/mL
Immersion fixed U266 human myeloma cell line

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunocytochemistry View Larger

OAS2 in U266 Human Cell Line. OAS2 was detected in immersion fixed U266 human myeloma cell line using Mouse Anti-Human OAS2 Monoclonal Antibody (Catalog # MAB1925) at 3 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; NL007) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. Staining was performed using our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: OAS2

OAS2, also known as OAS (69 kDa), is one of three related proteins (along with OAS1 and OAS3) that catalyze the conversion of ATP into 2’,5’-linked adenosine oligomers with the general formula pppA(2’,5’A)n where n > 1 (2, 3) These proteins are induced by interferons, activated by double-stranded RNA, and are implicated in anti-viral immunity (1, 4, 5).

References
  1. Hovanessian, A.G. et al. (1987) EMBO J. 6:1273.
  2. Hovanessian, A.G. et al. (1977) Nature 268:537.
  3. Kerr, I.M. and R.E. Brown (1978) Proc. Natl. Acad. Sci. USA 75:256.
  4. Hovanessian, A.G. et al. (1988) J. Biol. Chem. 263:4959.
  5. Marie, I. et al. (1990) J. Interferon Res. 10:571.
  6. Marie, I. et al. (1990) J. Biol. Chem. 265:18601.
Long Name
2’,5’-Oligoadenylate Synthetase-2
Entrez Gene IDs
4939 (Human)
Alternate Names
(2-5')oligo(A) synthase 2; (2'-5')oligo(A) synthetase 2; (2-5')oligo(A) synthetase 2; 2'5' oligoadenylate synthetase 2; 2-5A synthase 2; 2-5A synthetase 2; 2'-5'-oligoadenylate synthase 2; 2'-5'-oligoadenylate synthetase 2 (69-71 kD); 2'-5'-oligoadenylate synthetase 2, 69/71kDa; EC 2.7.7; EC 2.7.7.-; MGC78578; OAS2; p69 OAS / p71 OAS; p69OAS / p71OAS

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Citations for Human OAS2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Nucleotide oligomerization domain-2 interacts with 2'-5'-oligoadenylate synthetase type 2 and enhances RNase-L function in THP-1 cells.
    Authors: Dugan JW, Albor A, David L
    Mol. Immunol., 2009-10-23;47(2):560-6.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation, Western Blot
  2. Interactome and Proteome Dynamics Uncover Immune Modulatory Associations of the Pathogen Sensing Factor cGAS
    Authors: Krystal K. Lum, Bokai Song, Joel D. Federspiel, Benjamin A. Diner, Timothy Howard, Ileana M. Cristea
    Cell Systems

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Human OAS2 Antibody
By Anonymous on 07/12/2021
Application: WB Sample Tested: Fibroblast lysate Species: Human