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Human/Mouse/Rat/Hamster ACE-2 Antibody

Catalog #: AF933
281 Citations 3 Reviews Datasheet / COA / SDS
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AF933
AF933-SP
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Detection of Human, Mouse, and Rat ACE‑2 by Western Blot.
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Citations (281)
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Human/Mouse/Rat/Hamster ACE-2 Antibody Summary

Species Reactivity
Human, Mouse, Rat, Hamster
Specificity
Detects human ACE-2 in direct ELISAs. Detects human, mouse, and rat ACE-2 in Western blots. Detects Hamster ACE-2 in immunohistochemistry.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant human ACE-2
Gln18-Ser740
Accession # Q9BYF1
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
See below
Simple Western
10 µg/mL
See below
Flow Cytometry
0.25 µg/106 cells
See below
Immunohistochemistry
3-15 µg/mL
See below
Immunoprecipitation
25 µg/mL
Conditioned cell culture medium spiked with Recombinant Human ACE‑2 (Catalog # 933-ZN), see our available Western blot detection antibodies
Blockade of Receptor-ligand Interaction
Hoffman, M. et al. (2020) Cell. DOI:10.1016/j.cell.2020.02.052. This application was not tested by R&D Systems.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Human, Mouse, and Rat ACE‑2 antibody by Western Blot. View Larger

Detection of Human, Mouse, and Rat ACE‑2 by Western Blot. Western blot shows lysates of human kidney tissue, mouse kidney tissue, and rat kidney tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat/Hamster ACE-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF933) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for ACE-2 at approximately 100 and 110 kDa (as indicated). This experiment was conducted under reducing conditions and using Western Blot Buffer Group 1.

Flow Cytometry Detection of ACE-2 antibody in HEK293 Human Cell Line Transfected with Human ACE-2 and eGFP antibody by Flow Cytometry. View Larger

Detection of ACE-2 in HEK293 Human Cell Line Transfected with Human ACE-2 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with (A) human ACE-2 or (B) irrelevant protein, and eGFP was stained with Goat Anti-Human/Mouse/Rat/Hamster ACE-2 Affinity Purified Polyclonal Antibody (Catalog # AF933) followed by Allophycocyanin-conjugated Anti-Goat IgG Secondary Antibody (F0108). Quadrant markers were set based on Goat IgG control antibody (AB-108-C, data not shown). Staining was performed using our Staining Membrane-associated Proteins protocol.

Immunohistochemistry ACE-2 antibody in Human Kidney by Immunohistochemistry (IHC-P). View Larger

ACE‑2 in Human Kidney. ACE-2 was detected in immersion fixed paraffin-embedded sections of human kidney using Goat Anti-Human/Mouse/Rat/Hamster ACE-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF933) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Immunohistochemistry ACE-2 antibody in Human Kidney by Immunohistochemistry (IHC-P). View Larger

ACE‑2 in Human Kidney. ACE-2 was detected in immersion fixed paraffin-embedded sections of human kidney using Goat Anti-Human/Mouse/Rat/Hamster ACE-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF933) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). Lower panel shows a lack of labeling if primary antibodies are omitted and tissue is stained only with secondary antibody followed by incubation with detection reagents. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Immunohistochemistry ACE‑2 antibody in Hamster Lung by Immunohistochemistry (IHC-P). View Larger

ACE‑2 in Hamster Lung. ACE‑2 was detected in immersion fixed paraffin-embedded sections of hamster lung using Goat Anti-Human/Mouse/Rat/Hamster ACE‑2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF933) at 3 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to respiratory bronchioles. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Immunohistochemistry View Larger

ACE‑2 in Rat Lung. ACE‑2 was detected in immersion fixed frozen sections of rat lung using Goat Anti-Human/Mouse/Rat/Hamster ACE‑2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF933) at 10 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cell surface in eputhelial cells in bronchioles. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Immunohistochemistry View Larger

ACE‑2 in Rat Lung. ACE‑2 was detected in immersion fixed paraffin-embedded sections of rat lung using Goat Anti-Human/Mouse/Rat/Hamster ACE‑2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF933) at 10 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Immunohistochemistry View Larger

ACE‑2 in Rat Kidney. ACE‑2 was detected in immersion fixed paraffin-embedded sections of rat kidney using Goat Anti-Human/Mouse/Rat/Hamster ACE‑2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF933) at 10 µg/mL for 1 hour at room temperature followed by incubation with the Anti-Goat IgG VisUCyte™ HRP Polymer Antibody (VC004). Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (CTS013). Tissue was stained using DAB (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cell surface in convoluted tubules. Staining was performed using our protocol for IHC Staining with VisUCyte HRP Polymer Detection Reagents.

Simple Western Detection of Human ACE-2 antibody by Simple Western<SUP>TM</SUP>. View Larger

Detection of Human ACE‑2 by Simple WesternTM. Simple Western lane view shows lysates of human kidney tissue, loaded at 0.2 mg/mL. A specific band was detected for ACE-2 at approximately 155 kDa (as indicated) using 10 µg/mL of Goat Anti-Human/Mouse/Rat/Hamster ACE-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF933) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Western Blot Detection of Human ACE-2 by Western Blot View Larger

Detection of Human ACE-2 by Western Blot (A) Transduction of pLV pseudotyped with VSV-G (A,C) or CoV-2 Spike glycoprotein (B,D) in HEK293T (A,B) or Vero E6 (C,D) cells. The lentiviral backbone incorporates enhanced green fluorescent protein (eGFP) that is expressed upon integration into target cells. The fluorescence was recorded at 48 h post transduction. Magnification 4X. (E) Transduction efficiency of pLV pseudotyped with CoV-2 Spike glycoprotein in Vero E6, hACE2-HEK293T and 293T cells. The fluorescence was recorded at 48 h post transduction. The experiments were done in triplicates and standard error of mean was plotted as error bars. (F) Whole cell lysates from Vero E6, hACE2-293T and 293T cells were run on SDS-PAGE and probed with anti ACE2 antibody. Beta-actin was used as a loading control. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/33154514), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Mouse ACE-2 by Western Blot View Larger

Detection of Mouse ACE-2 by Western Blot Immunoblot analysis of ACE2 protein in the media from high glucose- or Ang II-stimulated mouse PT cells.(A) Mouse PT cells were incubated for 72 hrs in normal media (C, 7.8 mM D-glucose), with or without Ang II (10−7 M), high D-glucose (D-G, 25 mM), or high L-glucose (25 mM). Above graph is representative immunoblot for ACE2 in the media, showing bands at ∼90 kDa and ∼70 kDa. (B) Graphical representation of densitometry analysis of two ACE2 bands on immunoblots. For the ∼90 kDa band, *p<0.05 vs C, **p<0.001 vs C, **p<0.003 vs L-G; n = 5. For the ∼70 kDa band, *p<0.04 vs C; **p<0.001 vs C or L-G, **p<0.03 vs Ang II; n = 5. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0085958), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Mouse ACE-2 by Western Blot View Larger

Detection of Mouse ACE-2 by Western Blot Deglycosylation of ACE2 protein in media and cell lysates from mouse PT cells.Representative immunoblot for ACE2 treated without (−) or with (+) deglycosylation with PNGase F in the media (Lanes 1–2) and cell lysates (Lanes 3–4). Lanes 1 and 3: wildtype PT cells, Lanes 2 and 4: ACE2 knockout (KO) PT cells transfected with a human ACE2 vector, Lane 5: mouse kidney cortex. Lanes 1+ and 2+ show a reduction in the sizes of ACE2 fragments in media fractions to ∼75 kDa and ∼60 kDa for mouse ACE2, and to ∼80 kDa and ∼65 kDa for human ACE2, respectively. Lanes 3+ and 4+ show a reduction in the sizes of ACE2 in cell lysates to ∼85 kDa for both mouse and human ACE2 treated with the PNGase F, respectively. Lane 5+ shows a reduction in size of ACE2 in mouse cortex from ∼100 kDa to ∼85 kDa after treatment with PNGase F. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0085958), licensed under a CC-BY license. Not internally tested by R&D Systems.

Western Blot Detection of Mouse ACE-2 by Western Blot View Larger

Detection of Mouse ACE-2 by Western Blot Immunoblot analysis of ACE2 protein in media and cell lysates from mouse PT cells.(A) Representative immunoblot for ACE2 protein in concentrated media (Lanes 1–3) and cell lysates (Lanes 4–6) from mouse PT cells. Lanes 1 and 4: wildtype cells, Lanes 2 and 5: ACE2 knockout (KO) cells, Lanes 3 and 6: ACE2 KO cells transfected with a human ACE2 expression vector, Lane 7: mouse kidney cortex showing a band at ∼100 kDa, used as a positive control. Lane 1 shows two bands in the media at ∼90 kDa and ∼70 kDa for mouse ACE2. Lane 3 shows two bands in the media for human ACE2 in transfected cells, at ∼110 kDa and ∼95 kDa. Lanes 4 and 6 show a single band in cell lysates at ∼100 kDa for mouse ACE2, and ∼120 kDa for human ACE2, respectively. Lanes 2 and 5 show no ACE2 bands detected on immunoblots of both media and cell lysates from untransfected ACE2 KO cells. (B) Increased ACE2 activity in the media from ACE2 KO cells transfected with a human ACE2 expression vector (HA-hACE2, 3.75 µg on 35 mm culture dishes). Untransfected cells and cells transfected with an empty pcDNA3 vector had no detectable ACE2 activity in the media. Numbers in parentheses represent mean values for ACE2 activity. *P<0.001 vs untransfected control or empty pcDNA3 vector, n = 4. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0085958), licensed under a CC-BY license. Not internally tested by R&D Systems.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: ACE-2

ACE-2, also called ACEH (ACE homolog), is an integral membrane protein and a zinc metalloprotease of the ACE family that also includes somatic and germinal ACE (1). Human ACE-2 has about 40% amino acid identity to the N- and C-terminal domains of human somatic ACE. The predicted human ACE-2 protein sequence consists of 805 amino acids, including a N-terminal signal peptide, a single catalytic domain, a C-terminal membrane anchor, and a short cytoplasmic tail. ACE-2 cleaves angiotensins I and II as a carboxypeptidase. ACE-2 mRNA is found at high levels in testis, kidney, and heart and at moderate levels in colon, small intestine, and ovary. Classical ACE inhibitors such as captopril and lisinopril do not inhibit ACE-2 activity. Novel peptide inhibitors of ACE-2 do not inhibit ACE activity (2). Genetic data from Drosophila, mice and rats show that ACE-2 is an essential regulator of heart function in vivo (3).

ACE2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2 (4, 5). This Human anti-ACE2 antibody (catalog # AF933) was used to block the variant SARS-CoV-2 and ACE2 interaction to elucidate viral transmission and potential therapeutic strategies. (5)

References
  1. Tipnis, S.R. et al. (2000) J. Biol. Chem. 275:33238.
  2. Crackower,  M.A. et al. (2002) Nature 417:822.
  3. Huang, L. et al. (2003) J. Biol. Chem. 278:15532.
  4. Li, W. et al. (2003) Nature 426:450.
  5. Hoffmann, M. et al. (2020) Cell. DOI: 10.1016/j.cell.2020.02.052.
Long Name
Angiotensin I Converting Enzyme 2
Entrez Gene IDs
59272 (Human); 70008 (Mouse); 302668 (Rat); 100144303 (Porcine); 480847 (Canine); 418623 (Chicken); 102130864 (Cynomolgus Monkey); 554349 (Feline); 101673097 (Ferret); 101823817 (Hamster); 108390919 (Malayan Pangolin)
Alternate Names
ACE2; ACE-2; ACEH; ACEHangiotensin I converting enzyme 2; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; DKFZp434A014; EC 3.4.17; EC 3.4.17.23; Metalloprotease MPROT15

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Citations for Human/Mouse/Rat/Hamster ACE-2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

281 Citations: Showing 1 - 10
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  1. Decrease in Angiotensin-Converting Enzyme activity but not concentration in plasma/lungs in COVID-19 patients offers clues for diagnosis/treatment
    Authors: Henry Daniell, Smruti K. Nair, Yao Shi, Ping Wang, Kathleen T. Montone, Pamela A. Shaw et al.
    Molecular Therapy - Methods & Clinical Development
  2. The Upper Respiratory Tract of Felids Is Highly Susceptible to SARS-CoV-2 Infection
    Authors: Nadine Krüger, Cheila Rocha, Sandra Runft, Johannes Krüger, Iris Färber, Federico Armando et al.
    International Journal of Molecular Sciences
  3. Characterization of CCoV-HuPn-2018 spike protein-mediated viral entry
    Authors: Yongmei Liu, Danying Chen, Yuanyuan Wang, Xinglin Li, Yaruo Qiu, Mei Zheng et al.
    J Virol
  4. A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
    Authors: Joep Beumer, Maarten H. Geurts, Mart M. Lamers, Jens Puschhof, Jingshu Zhang, Jelte van der Vaart et al.
    Nature Communications
  5. Identification of potent inhibitors of SARS-CoV-2 infection by combined pharmacological evaluation and cellular network prioritization
    Authors: J.J. Patten, Patrick T. Keiser, Deisy Morselli-Gysi, Giulia Menichetti, Hiroyuki Mori, Callie J. Donahue et al.
    iScience
  6. Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death
    Authors: Sauve F, Nampoothiri S, Clarke SA et al.
    EBioMedicine
  7. Identification of FDA-approved bifonazole as a SARS-CoV-2 blocking agent following a bioreporter drug screen
    Authors: Zaid Taha, Rozanne Arulanandam, Glib Maznyi, Elena Godbout, Madalina E. Carter-Timofte, Naziia Kurmasheva et al.
    Molecular Therapy
  8. ZMPSTE24 Regulates SARS-CoV-2 Spike Protein–enhanced Expression of Endothelial PAI-1
    Authors: Mingming Han, Deepesh Pandey
    American Journal of Respiratory Cell and Molecular Biology
  9. Clinical and in Vitro Evidence against Placenta Infection at Term by Severe Acute Respiratory Syndrome Coronavirus 2
    Authors: Arthur Colson, Christophe L. Depoix, Géraldine Dessilly, Pamela Baldin, Olivier Danhaive, Corinne Hubinont et al.
    The American Journal of Pathology
  10. ACE2 downregulation in olfactory mucosa: Eosinophilic rhinosinusitis as COVID‐19 protective factor?
    Authors: Concepció Marin, Valeria Tubita, Cristóbal Langdon, Mireya Fuentes, María Jesús Rojas‐Lechuga, Antonio Valero et al.
    Allergy
  11. A Replication-Competent Vesicular Stomatitis Virus for Studies of SARS-CoV-2 Spike-Mediated Cell Entry and Its Inhibition
    Authors: M. Eugenia Dieterle, Denise Haslwanter, Robert H. Bortz, Ariel S. Wirchnianski, Gorka Lasso, Olivia Vergnolle et al.
    Cell Host & Microbe
  12. Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in Chronic Obstructive Pulmonary Disease
    Authors: Jaspreet Osan, Sattya N. Talukdar, Friederike Feldmann, Beth Ann DeMontigny, Kailey Jerome, Kristina L. Bailey et al.
    Microbiology Spectrum
  13. Broad and Differential Animal Angiotensin-Converting Enzyme 2 Receptor Usage by SARS-CoV-2
    Authors: Xuesen Zhao, Danying Chen, Robert Szabla, Mei Zheng, Guoli Li, Pengcheng Du et al.
    Journal of Virology
  14. SARS-CoV-2 infection of human iPSC-derived cardiac cells predicts novel cytopathic features in hearts of COVID-19 patients
    Authors: Juan A. Pérez-Bermejo, Serah Kang, Sarah J. Rockwood, Camille R. Simoneau, David A. Joy, Gokul N. Ramadoss et al.
    bioRxiv
  15. Carbohydrate-binding protein from stinging nettle as fusion inhibitor for SARS-CoV-2 variants of concern
    Authors: Emiel Vanhulle, Thomas D’huys, Becky Provinciael, Joren Stroobants, Anita Camps, Sam Noppen et al.
    Frontiers in Cellular and Infection Microbiology
  16. TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry
    Authors: Jim Baggen, Maarten Jacquemyn, Leentje Persoons, Els Vanstreels, Valerie E. Pye, Antoni G. Wrobel et al.
    Cell
  17. A cell-based assay for rapid assessment of ACE2 catalytic function
    Authors: Warren M. Meyers, Ryan J. Hong, Wun Chey Sin, Christine S. Kim, Kurt Haas
    Scientific Reports
  18. ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker
    Authors: Yuning Chen, Ya-Nan Zhang, Renhong Yan, Guifeng Wang, Yuanyuan Zhang, Zhe-Rui Zhang et al.
    Signal Transduction and Targeted Therapy
  19. CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses
    Authors: Sallieu Jalloh, Judith Olejnik, Jacob Berrigan, Annuurun Nisa, Ellen L Suder, Hisashi Akiyama et al.
    bioRxiv
  20. The RNA Interference Effector Protein Argonaute 2 Functions as a Restriction Factor Against SARS-CoV-2
    Authors: Joaquin Lopez-Orozco, Nawell Fayad, Juveriya Qamar Qamar Khan, Alberto Felix-Lopez, Mohamed Elaish, Megha Rohamare et al.
    Journal of Molecular Biology
  21. Nonproductive exposure of PBMCs to SARS‐CoV ‐2 induces cell‐intrinsic innate immune responses
    Authors: Julia Kazmierski, Kirstin Friedmann, Dylan Postmus, Jackson Emanuel, Cornelius Fischer, Jenny Jansen et al.
    Molecular Systems Biology
  22. Unbiased interrogation of memory B cells from convalescent COVID-19 patients reveals a broad antiviral humoral response targeting SARS-CoV-2 antigens beyond the spike protein
    Authors: Jillian M. DiMuzio, Baron C. Heimbach, Raymond J. Howanski, John P. Dowling, Nirja B. Patel, Noeleya Henriquez et al.
    Vaccine: X
  23. A novel method for high-throughput screening to quantify antiviral activity against viruses that induce limited CPE
    Authors: Dirk Jochmans, Pieter Leyssen, Johan Neyts
    Journal of Virological Methods
  24. Sec61 Inhibitor Apratoxin S4 Potently Inhibits SARS-CoV-2 and Exhibits Broad-Spectrum Antiviral Activity
    Authors: Marie O. Pohl, Laura Martin-Sancho, Ranjala Ratnayake, Kris M. White, Laura Riva, Qi-Yin Chen et al.
    ACS Infectious Diseases
  25. SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro
    Authors: Fengming Liu, Kun Han, Robert Blair, Kornelia Kenst, Zhongnan Qin, Berin Upcin et al.
    Frontiers in Cellular and Infection Microbiology
  26. Human embryonic stem cell-derived cardiomyocyte platform screens inhibitors of SARS-CoV-2 infection
    Authors: Thomas L. Williams, Maria T. Colzani, Robyn G. C. Macrae, Emma L. Robinson, Stuart Bloor, Edward J. D. Greenwood et al.
    Communications Biology
  27. Species-Specific Molecular Barriers to SARS-CoV-2 Replication in Bat Cells
    Authors: Sophie-Marie Aicher, Felix Streicher, Maxime Chazal, Delphine Planas, Dongsheng Luo, Julian Buchrieser et al.
    Journal of Virology
  28. SARS-CoV-2 Poorly Replicates in Cells of the Human Blood-Brain Barrier Without Associated Deleterious Effects
    Authors: Orianne Constant, Jonathan Barthelemy, Karine Bolloré, Edouard Tuaillon, Fabien Gosselet, Christine Chable-Bessia et al.
    Frontiers in Immunology
  29. Low-Density Lipoprotein Receptor (LDLR) Is Involved in Internalization of Lentiviral Particles Pseudotyped with SARS-CoV-2 Spike Protein in Ocular Cells
    Authors: Uppal S, Postnikova O, Villasmil R et al.
    International journal of molecular sciences
  30. LY6E impairs coronavirus fusion and confers immune control of viral disease
    Authors: Stephanie Pfaender, Katrina B. Mar, Eleftherios Michailidis, Annika Kratzel, Ian N. Boys, Philip V’kovski et al.
    Nature Microbiology
  31. Quinolines-Based SARS-CoV-2 3CLpro and RdRp Inhibitors and Spike-RBD-ACE2 Inhibitor for Drug-Repurposing Against COVID-19: An in silico Analysis
    Authors: Rajaiah Alexpandi, Joelma Freire De Mesquita, Shunmugiah Karutha Pandian, Arumugam Veera Ravi
    Frontiers in Microbiology
  32. ACE2 overexpression inhibits acquired platinum resistance-induced tumor angiogenesis in NSCLC
    Oncol Rep, 2016-07-22;36(3):1403-10.
  33. SuPAR mediates viral response proteinuria by rapidly changing podocyte function
    Authors: Wei, C;Datta, PK;Siegerist, F;Li, J;Yashwanth, S;Koh, KH;Kriho, NW;Ismail, A;Luo, S;Fischer, T;Amber, KT;Cimbaluk, D;Landay, A;Endlich, N;Rappaport, J;Michigan Medicine COVID−19 Investigators, ;Hayek, SS;Reiser, J;
    Nature communications
  34. Development of an efficient reproducible cell-cell transmission assay for rapid quantification of SARS-CoV-2 spike interaction with hACE2
    Authors: George Ssenyange, Maya Kerfoot, Min Zhao, Shelli Farhadian, Sidi Chen, Lei Peng et al.
    Cell Reports Methods
  35. VE607 stabilizes SARS-CoV-2 Spike in the “RBD-up” conformation and inhibits viral entry
    Authors: Shilei Ding, Irfan Ullah, Shang Yu Gong, Jonathan R. Grover, Mohammadjavad Mohammadi, Yaozong Chen et al.
    iScience
  36. SARS-CoV-2 disrupts proximal elements in the JAK-STAT pathway
    Authors: Chen Dy, Khan N, Close Bj Et Al.
    Journal of virology
  37. Low-density lipoprotein receptor–related protein 1 (LRP1) as an auxiliary host factor for RNA viruses
    Authors: Stephanie Devignot, Tim Wai Sha, Thomas R Burkard, Patrick Schmerer, Astrid Hagelkruys, Ali Mirazimi et al.
    Life Science Alliance
  38. SARS-CoV-2 Permissive glioblastoma cell line for high throughput antiviral screening
    Authors: Emiel Vanhulle, Joren Stroobants, Becky Provinciael, Anita Camps, Sam Noppen, Piet Maes et al.
    Antiviral Research
  39. Discovery of Small Anti‐ACE2 Peptides to Inhibit SARS‐CoV‐2 Infectivity
    Authors: Pratik Adhikary, Sashi Kandel, Umar‐Farouk Mamani, Bahaa Mustafa, Siyuan Hao, Jianming Qiu et al.
    Advanced Therapeutics
  40. SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity
    Authors: Chihiro Motozono, Mako Toyoda, Jiri Zahradnik, Akatsuki Saito, Hesham Nasser, Toong Seng Tan et al.
    Cell Host & Microbe
  41. Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells
    Authors: Kelly S. Schweitzer, Taylor Crue, Jordan M. Nall, Daniel Foster, Satria Sajuthi, Kelly A. Correll et al.
    European Respiratory Journal
  42. Human iPSC-Derived Cardiomyocytes Are Susceptible to SARS-CoV-2 Infection
    Authors: Arun Sharma, Gustavo Garcia, Yizhou Wang, Jasmine T. Plummer, Kouki Morizono, Vaithilingaraja Arumugaswami et al.
    Cell Reports Medicine
  43. Potential role of astrocyte angiotensin converting enzyme 2 in the neural transmission of COVID-19 and a neuroinflammatory state induced by smoking and vaping
    Authors: Zhang Y, Archie SR, Ghanwatkar Y et al.
    Fluids and Barriers of the CNS
  44. ADAM10 and ADAM17 promote SARS‐CoV‐2 cell entry and spike protein‐mediated lung cell fusion
    Authors: Georg Jocher, Vincent Grass, Sarah K Tschirner, Lydia Riepler, Stephan Breimann, Tuğberk Kaya et al.
    EMBO reports
  45. ACE2-Independent Interaction of SARS-CoV-2 Spike Protein with Human Epithelial Cells Is Inhibited by Unfractionated Heparin
    Authors: Lynda J. Partridge, Lucy Urwin, Martin J. H. Nicklin, David C. James, Luke R. Green, Peter N. Monk
    Cells
  46. IMMUNO-COV v2.0: Development and Validation of a High-Throughput Clinical Assay for Measuring SARS-CoV-2-Neutralizing Antibody Titers
    Authors: Rianna Vandergaast, Timothy Carey, Samantha Reiter, Chase Lathrum, Patrycja Lech, Clement Gnanadurai et al.
    mSphere
  47. Increased colonic expression of ACE2 associates with poor prognosis in Crohn’s disease
    Authors: Takahiko Toyonaga, Kenza C. Araba, Meaghan M. Kennedy, Benjamin P. Keith, Elisabeth A. Wolber, Caroline Beasley et al.
    Scientific Reports
  48. SARS-CoV-2 infects an upper airway model derived from induced pluripotent stem cells
    Authors: Ivo Djidrovski, Maria Georgiou, Grant L. Hughes, Edward I. Patterson, Aitor Casas-Sanchez, Shaun H. Pennington et al.
    Stem Cells
  49. A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids
    Authors: L Yang, Y Han, BE Nilsson-Pa, V Gupta, P Wang, X Duan, X Tang, J Zhu, Z Zhao, F Jaffré, T Zhang, TW Kim, O Harschnitz, D Redmond, S Houghton, C Liu, A Naji, G Ciceri, S Guttikonda, Y Bram, DT Nguyen, M Cioffi, V Chandar, DA Hoagland, Y Huang, J Xiang, H Wang, D Lyden, A Borczuk, HJ Chen, L Studer, FC Pan, DD Ho, BR tenOever, T Evans, RE Schwartz, S Chen
    Cell Stem Cell, 2020-06-19;27(1):125-136.e7.
  50. Overcoming Culture Restriction for SARS-CoV-2 in Human Cells Facilitates the Screening of Compounds Inhibiting Viral Replication
    Authors: Santseharay Ramirez, Carlota Fernandez-Antunez, Andrea Galli, Alexander Underwood, Long V. Pham, Line A. Ryberg et al.
    Antimicrobial Agents and Chemotherapy
  51. Fetal brain vulnerability to SARS-CoV-2 infection
    Authors: McMahon CL, Castro J, Silvas J et al.
    Brain, behavior, and immunity
  52. Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung Cancer
    Authors: Jingwen Yue, Weihua Jin, Hua Yang, John Faulkner, Xuehong Song, Hong Qiu et al.
    Frontiers in Molecular Biosciences
  53. Immunosuppressant Treatment in Rheumatic Musculoskeletal Diseases Does Not Inhibit Elicitation of Humoral Response to SARS-CoV-2 Infection and Preserves Effector Immune Cell Populations
    Authors: Andrea Favalli, Ennio Giulio Favalli, Andrea Gobbini, Elena Zagato, Mauro Bombaci, Gabriella Maioli et al.
    Frontiers in Immunology
  54. Viral infiltration of pancreatic islets in patients with COVID-19
    Authors: C Steenblock, S Richter, I Berger, M Barovic, J Schmid, U Schubert, N Jarzebska, A von Mässen, A Linkermann, A Schürmann, J Pablik, T Dienemann, K Evert, RN Rodionov, NY Semenova, VA Zinserling, RR Gainetdino, G Baretton, D Lindemann, M Solimena, B Ludwig, SR Bornstein
    Nature Communications, 2021-06-10;12(1):3534.
  55. The Priming Potential of Interferon Lambda-1 for Antiviral Defense in the Oral Mucosa
    Authors: Yosuke Shikama, Mie Kurosawa, Masae Furukawa, Yasusei Kudo, Naozumi Ishimaru, Kenji Matsushita
    Inflammation
  56. Biomimetic SARS-CoV-2 Spike Protein Nanoparticles
    Authors: Alvin Phan, Hugo Avila, J. Andrew MacKay
    Biomacromolecules
  57. Human Immunodeficiency Viruses Pseudotyped with SARS-CoV-2 Spike Proteins Infect a Broad Spectrum of Human Cell Lines through Multiple Entry Mechanisms
    Authors: C Xu, A Wang, K Geng, W Honnen, X Wang, N Bruiners, S Singh, F Ferrara, S D'Angelo, ARM Bradbury, ML Gennaro, D Liu, A Pinter, TL Chang
    Viruses, 2021-05-21;13(6):.
  58. Synthetic carbohydrate-binding agents neutralize SARS-CoV-2 by inhibiting binding of the spike protein to ACE2
    Authors: Oscar Francesconi, Lorena Donnici, Marco Fragai, Elisa Pesce, Mauro Bombaci, Alessandra Fasciani et al.
    iScience
  59. Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus
    Authors: Da-Yuan Chen, Jacquelyn Turcinovic, Shuchen Feng, Devin J. Kenney, Chue Vin Chin, Manish C. Choudhary et al.
    iScience
  60. ACE2‐enriched extracellular vesicles enhance infectivity of live SARS‐CoV‐2 virus
    Authors: Sze Keong Tey, Hoiyan Lam, Samuel Wan Ki Wong, Hanjun Zhao, Kelvin Kai‐Wang To, Judy Wai Ping Yam
    Journal of Extracellular Vesicles
  61. Structural insights of a highly potent pan-neutralizing SARS-CoV-2 human monoclonal antibody
    Authors: Jonathan L. Torres, Gabriel Ozorowski, Emanuele Andreano, Hejun Liu, Jeffrey Copps, Giulia Piccini et al.
    Proceedings of the National Academy of Sciences
  62. SARS-CoV-2 and SARS-CoV Spike-Mediated Cell-Cell Fusion Differ in Their Requirements for Receptor Expression and Proteolytic Activation
    Authors: Hornich BF, Grobkopf AK, Schlagowski S et al.
    Journal of Virology
  63. Insect cell expression and purification of recombinant SARS‐COV‐2 spike proteins that demonstrate ACE2 binding
    Authors: Lucas R. Struble, Audrey L. Smith, William E. Lutz, Gabrielle Grubbs, Satish Sagar, Kenneth W. Bayles et al.
    Protein Science
  64. Inhibition of SARS-CoV-2 replication in the lung with siRNA/VIPER polyplexes
    Authors: Domizia Baldassi, Shubhankar Ambike, Martin Feuerherd, Cho-Chin Cheng, David J. Peeler, Daniel P. Feldmann et al.
    Journal of Controlled Release
  65. Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2
    Authors: Timothy Klouda, Yuan Hao, Hyunbum Kim, Jiwon Kim, Judith Olejnik, Adam J. Hume et al.
    Angiogenesis
  66. Susceptibility to SARS-CoV-2 of Cell Lines and Substrates Commonly Used to Diagnose and Isolate Influenza and Other Viruses
    Authors: Li Wang, Xiaoyu Fan, Gaston Bonenfant, Dan Cui, Jaber Hossain, Nannan Jiang et al.
    Emerging Infectious Diseases
  67. SARS-CoV-2 infection induces beta cell transdifferentiation
    Authors: Tang X, Uhl S, Zhang T et al.
    Cell Metabolism
  68. A tissue- and gender-specific regulation of the SARS-CoV-2 receptor ACE2 by p53 in pigs
    Authors: Yue Zhang, Guanglin Niu, Tatiana Flisikowska, Angelika Schnieke, Krzysztof Flisikowski
    Biochemical and Biophysical Research Communications
  69. SARS-CoV-2 induces human plasmacytoid predendritic cell diversification via UNC93B and IRAK4
    Authors: Fanny Onodi, Lucie Bonnet-Madin, Laurent Meertens, Léa Karpf, Justine Poirot, Shen-Ying Zhang et al.
    Journal of Experimental Medicine
  70. Term Human Placental Trophoblasts Express SARS-CoV-2 Entry Factors ACE2, TMPRSS2, and Furin
    Authors: Yingshi Ouyang, Tarique Bagalkot, Wendy Fitzgerald, Elena Sadovsky, Tianjiao Chu, Ana Martínez-Marchal et al.
    mSphere
  71. SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase
    Authors: Pinja Kettunen, Angelina Lesnikova, Noora Räsänen, Ravi Ojha, Leena Palmunen, Markku Laakso et al.
    Journal of Virology
  72. ORF10–Cullin-2–ZYG11B complex is not required for SARS-CoV-2 infection
    Authors: Elijah L. Mena, Callie J. Donahue, Laura Pontano Vaites, Jie Li, Gergely Rona, Colin O’Leary et al.
    Proceedings of the National Academy of Sciences
  73. A replication-competent vesicular stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition
    Authors: M. Eugenia Dieterle, Denise Haslwanter, Robert H. Bortz, Ariel S. Wirchnianski, Gorka Lasso, Olivia Vergnolle et al.
    bioRxiv
  74. Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
    Authors: Maritza Puray-Chavez, Kyle M. LaPak, Travis P. Schrank, Jennifer L. Elliott, Dhaval P. Bhatt, Megan J. Agajanian et al.
    bioRxiv
  75. Immediate myeloid depot for SARS-CoV-2 in the human lung
    Authors: Mélia Magnen, Ran You, Arjun A. Rao, Ryan T. Davis, Lauren Rodriguez, Camille R. Simoneau et al.
    Research Square
  76. SARS-CoV-2 Employ BSG/CD147 and ACE2 Receptors to Directly Infect Human Induced Pluripotent Stem Cell-Derived Kidney Podocytes
    Authors: Titilola D. Kalejaiye, Rohan Bhattacharya, Morgan A. Burt, Tatianna Travieso, Arinze E. Okafor, Xingrui Mou et al.
    Frontiers in Cell and Developmental Biology
  77. Identification of Human Host Substrates of the SARS-CoV-2 Mpro and PLpro Using Subtiligase N-Terminomics
    Authors: Shu Y. Luo, Eman W. Moussa, Joaquin Lopez-Orozco, Alberto Felix-Lopez, Ray Ishida, Nawell Fayad et al.
    ACS Infectious Diseases
  78. Histology and cytokine levels in hepatic injury accompanying a case of non-severe COVID-19
    Authors: Hidetaka Matsuda, Takuto Nosaka, Katsushi Hiramatsu, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji et al.
    Clinical Journal of Gastroenterology
  79. Acute Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Pregnancy Is Associated with Placental Angiotensin-Converting Enzyme 2 Shedding
    Authors: Elizabeth S. Taglauer, Elisha M. Wachman, Lillian Juttukonda, Timothy Klouda, Jiwon Kim, Qiong Wang et al.
    The American Journal of Pathology
  80. CDK4/6 inhibitor palbociclib promotes SARS-CoV-2 cell entry by down-regulating SKP2 dependent ACE2 degradation
    Authors: Yingzi Xiao, Ying Yan, Le Chang, Huimin Ji, Huizhen Sun, Shi Song et al.
    Antiviral Research
  81. SARS‐CoV‐2 infection activates dendritic cells via cytosolic receptors rather than extracellular TLRs
    Authors: Lieve E.H. van der Donk, Julia Eder, John L. van Hamme, Philip J. M. Brouwer, Mitch Brinkkemper, Ad C. van Nuenen et al.
    European Journal of Immunology
  82. Protocols for SARS-CoV-2 infection in primary ocular cells and eye organoids
    Authors: Eriksen A, Moller R, Markovoz B et al.
    STAR Protocols
  83. BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection
    Authors: Richard J. Mills, Sean J. Humphrey, Patrick R.J. Fortuna, Mary Lor, Simon R. Foster, Gregory A. Quaife-Ryan et al.
    Cell
  84. The angiotensin-converting enzyme 2 in tumor growth and tumor-associated angiogenesis in non-small cell lung cancer
    Authors: Yun Feng, Huanying Wan, Jialin Liu, Ruifeng Zhang, Qinyun Ma, Bing Han et al.
    Oncology Reports
  85. Severe Acute Respiratory Syndrome Coronavirus 2–Induced Immune Activation and Death of Monocyte-Derived Human Macrophages and Dendritic Cells
    Authors: Jian Zheng, Yuhang Wang, Kun Li, David K Meyerholz, Chantal Allamargot, Stanley Perlman
    The Journal of Infectious Diseases
  86. Molecular consequences of SARS-CoV-2 liver tropism
    Authors: Nicola Wanner, Geoffroy Andrieux, Pau Badia-i-Mompel, Carolin Edler, Susanne Pfefferle, Maja T. Lindenmeyer et al.
    Nature Metabolism
  87. Selection and Validation of siRNAs Preventing Uptake and Replication of SARS-CoV-2
    Authors: Maik Friedrich, Gabriele Pfeifer, Stefanie Binder, Achim Aigner, Philippe Vollmer Barbosa, Gustavo R. Makert et al.
    Frontiers in Bioengineering and Biotechnology
  88. ACE2-independent infection of T lymphocytes by SARS-CoV-2
    Authors: Xu-Rui Shen, Rong Geng, Qian Li, Ying Chen, Shu-Fen Li, Qi Wang et al.
    Signal Transduction and Targeted Therapy
  89. Exploring Zebrafish Larvae as a COVID-19 Model: Probable Abortive SARS-CoV-2 Replication in the Swim Bladder
    Authors: Valerio Laghi, Veronica Rezelj, Laurent Boucontet, Maxence Frétaud, Bruno Da Costa, Pierre Boudinot et al.
    Frontiers in Cellular and Infection Microbiology
  90. Limited extent and consequences of pancreatic SARS-CoV-2 infection
    Authors: Verena van der Heide, Sonia Jangra, Phillip Cohen, Raveen Rathnasinghe, Sadaf Aslam, Teresa Aydillo et al.
    Cell Reports
  91. Therapeutic activity of an inhaled potent SARS-CoV-2 neutralizing human monoclonal antibody in hamsters
    Authors: Michael S. Piepenbrink, Jun-Gyu Park, Fatai S. Oladunni, Ashlesha Deshpande, Madhubanti Basu, Sanghita Sarkar et al.
    Cell Reports Medicine
  92. Neuroinvasion of SARS-CoV-2 in human and mouse brain
    Authors: Song E, Zhang C, Israelow B et al.
    Journal of Experimental Medicine
  93. Tubeimosides are pan-coronavirus and filovirus inhibitors that can block their fusion protein binding to Niemann-Pick C1
    Authors: Khan, I;Li, S;Tao, L;Wang, C;Ye, B;Li, H;Liu, X;Ahmad, I;Su, W;Zhong, G;Wen, Z;Wang, J;Hua, RH;Ma, A;Liang, J;Wan, XP;Bu, ZG;Zheng, YH;
    Nature communications
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  94. Decoy peptides effectively inhibit the binding of SARS-CoV-2 to ACE2 on oral epithelial cells
    Authors: Loi, LK;Yang, CC;Lin, YC;Su, YF;Juan, YC;Chen, YH;Chang, HC;
    Heliyon
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  95. Antiviral responses in a Jamaican fruit bat intestinal organoid model of SARS-CoV-2 infection
    Authors: Hashimi, M;Sebrell, TA;Hedges, JF;Snyder, D;Lyon, KN;Byrum, SD;Mackintosh, SG;Crowley, D;Cherne, MD;Skwarchuk, D;Robison, A;Sidar, B;Kunze, A;Loveday, EK;Taylor, MP;Chang, CB;Wilking, JN;Walk, ST;Schountz, T;Jutila, MA;Bimczok, D;
    Nature communications
    Species: Mouse
    Sample Types: Organoids
    Applications: IHC
  96. Regulatory T cell-like response to SARS-CoV-2 in Jamaican fruit bats (Artibeus jamaicensis) transduced with human ACE2
    Authors: Burke, B;Rocha, SM;Zhan, S;Eckley, M;Reasoner, C;Addetia, A;Lewis, J;Fagre, A;Charley, PA;Richt, JA;Weiss, SR;Tjalkens, RB;Veesler, D;Aboellail, T;Schountz, T;
    PLoS pathogens
    Species: Bat
    Sample Types: Whole Tissue
    Applications: IHC
  97. Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection
    Authors: Mhlekude, B;Postmus, D;Stenzel, S;Weiner, J;Jansen, J;Zapatero-Belinchón, FJ;Olmer, R;Richter, A;Heinze, J;Heinemann, N;Mühlemann, B;Schroeder, S;Jones, TC;Müller, MA;Drosten, C;Pich, A;Thiel, V;Martin, U;Niemeyer, D;Gerold, G;Beule, D;Goffinet, C;
    PLoS pathogens
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  98. Genetically diverse mouse models of SARS-CoV-2 infection reproduce clinical variation in type I interferon and cytokine responses in COVID-19
    Authors: Robertson, SJ;Bedard, O;McNally, KL;Shaia, C;Clancy, CS;Lewis, M;Broeckel, RM;Chiramel, AI;Shannon, JG;Sturdevant, GL;Rosenke, R;Anzick, SL;Forte, E;Preuss, C;Baker, CN;Harder, JM;Brunton, C;Munger, S;Bruno, DP;Lack, JB;Leung, JM;Shamsaddini, A;Gardina, P;Sturdevant, DE;Sun, J;Martens, C;Holland, SM;Rosenthal, NA;Best, SM;
    Nature communications
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  99. Proteolytic cleavage and inactivation of the TRMT1 tRNA modification enzyme by SARS-CoV-2 main protease
    Authors: Zhang, K;Eldin, P;Ciesla, JH;Briant, L;Lentini, JM;Ramos, J;Cobb, J;Munger, J;Fu, D;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  100. Effective SARS-CoV-2 replication of monolayers of intestinal epithelial cells differentiated from human induced pluripotent stem cells
    Authors: Minami, S;Matsumoto, N;Omori, H;Nakamura, Y;Tamiya, S;Nouda, R;Nurdin, JA;Yamasaki, M;Kotaki, T;Kanai, Y;Okamoto, T;Tachibana, T;Ushijima, H;Kobayashi, T;Sato, S;
    Scientific reports
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  101. PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection
    Authors: Xu, D;Jiang, W;Wu, L;Gaudet, RG;Park, ES;Su, M;Cheppali, SK;Cheemarla, NR;Kumar, P;Uchil, PD;Grover, JR;Foxman, EF;Brown, CM;Stansfeld, PJ;Bewersdorf, J;Mothes, W;Karatekin, E;Wilen, CB;MacMicking, JD;
    Nature
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  102. An inducible hACE2 transgenic mouse model recapitulates SARS-CoV-2 infection and pathogenesis in vivo
    Authors: Liu, K;Tang, M;Xu, W;Meng, X;Jin, H;Han, M;Pu, J;Li, Y;Jiao, F;Sun, R;Shen, R;Lui, KO;Lu, L;Zhou, B;
    Proceedings of the National Academy of Sciences of the United States of America
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  103. Generation of a SARS-CoV-2 Reverse Genetics System and Novel Human Lung Cell Lines That Exhibit High Virus-Induced Cytopathology
    Authors: Khan, JQ;Rohamare, M;Rajamanickam, K;Bhanumathy, KK;Lew, J;Kumar, A;Falzarano, D;Vizeacoumar, FJ;Wilson, JA;
    Viruses
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  104. COVID-19-related hyperglycemia is associated with infection of hepatocytes and stimulation of gluconeogenesis
    Authors: Barreto, EA;Cruz, AS;Veras, FP;Martins, R;Bernardelli, RS;Paiva, IM;Lima, TM;Singh, Y;Guimar�es, RC;Damasceno, S;Pereira, N;Alves, JM;Gon�alves, TT;Forato, J;Muraro, SP;Souza, GF;Batah, SS;Proenca-Modena, JL;Mori, MA;Cunha, FQ;Louzada-Junior, P;Cunha, TM;Nakaya, HI;Fabro, A;de Oliveira, RDR;Arruda, E;R�a, R;R�a Neto, �;Fernandes da Silva, MM;Leiria, LO;
    Proceedings of the National Academy of Sciences of the United States of America
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  105. Neutrophil Elastase decreases SARS-CoV-2 Spike protein binding to human bronchial epithelia by clipping ACE-2 ectodomian from the epithelial surface
    Authors: Kummarapurugu, AB;Hawkridge, AM;Ma, J;Osei, S;Martin, RK;Zheng, S;Voynow, JA;
    The Journal of biological chemistry
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  106. Characterisation of the Antibody Response in Sinopharm (BBIBP-CorV) Recipients and COVID-19 Convalescent Sera from the Republic of Moldova
    Authors: M Ulinici, A Sulji?, M Poggianell, R Milan Bono, K Resman Rus, A Paraschiv, AM Bonetti, M Todiras, A Corlateanu, S Groppa, E Ceban, M Petrovec, A Marcello
    Vaccines, 2023-03-13;11(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: FLOW
  107. Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection
    Authors: AT Tang, DW Buchholz, KM Szigety, B Imbiakha, S Gao, M Frankfurte, M Wang, J Yang, P Hewins, P Mericko-Is, NA Leu, S Sterling, IA Monreal, J Sahler, A August, X Zhu, KA Jurado, M Xu, EE Morrisey, SE Millar, HC Aguilar, ML Kahn
    PloS Biology, 2023-02-06;21(2):e3001989.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  108. Generation and Characterization of a SARS-CoV-2-Susceptible Mouse Model Using Adeno-Associated Virus (AAV6.2FF)-Mediated Respiratory Delivery of the Human ACE2 Gene
    Authors: N Tailor, BM Warner, BD Griffin, K Tierney, E Moffat, K Frost, R Vendramell, A Leung, M Willman, SP Thomas, Y Pei, SA Booth, C Embury-Hya, SK Wootton, D Kobasa
    Viruses, 2022-12-28;15(1):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  109. Mapping of functional SARS-CoV-2 receptors in human lungs establishes differences in variant binding and SLC1A5 as a viral entry modulator of hACE2
    Authors: A Miluzio, A Cuomo, C Cordiglier, L Donnici, E Pesce, M Bombaci, M Conti, A Fasciani, L Terraccian, L Manganaro, M Toccafondi, A Scagliola, S Oliveto, S Ricciardi, R Grifantini, R De Frances, S Abrignani, N Manfrini, S Biffo
    EBioMedicine, 2022-12-28;87(0):104390.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells, Whole Tissue
    Applications: Co-Immunoprecipitation, Flow Cytometry, IHC, Western Blot
  110. Control of SARS-CoV-2 infection by MT1-MMP-mediated shedding of ACE2
    Authors: X Guo, J Cao, JP Cai, J Wu, J Huang, P Asthana, SKK Wong, ZW Ye, S Gurung, Y Zhang, S Wang, Z Wang, X Ge, HY Kwan, A Lyu, KM Chan, N Wong, J Huang, Z Zhou, ZX Bian, S Yuan, HLX Wong
    Nature Communications, 2022-12-23;13(1):7907.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  111. TRPC3-Nox2 Protein Complex Formation Increases the Risk of SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through ACE2 Upregulation
    Authors: Y Kato, K Nishiyama, J Man Lee, Y Ibuki, Y Imai, T Noda, N Kamiya, T Kusakabe, Y Kanda, M Nishida
    International Journal of Molecular Sciences, 2022-12-21;24(1):.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  112. SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-beta signaling
    Authors: SB Biering, FT Gomes de S, LV Tjang, F Pahmeier, C Zhu, R Ruan, SF Blanc, TS Patel, CM Worthingto, DR Glasner, B Castillo-R, V Servellita, NTN Lo, MP Wong, CM Warnes, DR Sandoval, TM Clausen, YA Santos, DM Fox, V Ortega, AM Näär, RS Baric, SA Stanley, HC Aguilar, JD Esko, CY Chiu, JE Pak, PR Beatty, E Harris
    Nature Communications, 2022-12-09;13(1):7630.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  113. Severe acute respiratory disease in American mink experimentally infected with SARS-CoV-2
    Authors: DR Adney, J Lovaglio, JE Schulz, CK Yinda, VA Avanzato, E Haddock, JR Port, MG Holbrook, PW Hanley, G Saturday, D Scott, C Shaia, AM Nelson, JR Spengler, C Tansey, CM Cossaboom, NM Wendling, C Martens, J Easley, SW Yap, SN Seifert, VJ Munster
    JCI Insight, 2022-11-22;7(22):.
    Species: Mink
    Sample Types: Whole Tissue
    Applications: IHC
  114. ACE2-Independent Bat Sarbecovirus Entry and Replication in Human and Bat Cells
    Authors: H Guo, A Li, TY Dong, J Su, YL Yao, Y Zhu, ZL Shi, M Letko
    MBio, 2022-11-21;0(0):e0256622.
    Species: Bat, Human
    Sample Types: Whole Cells
    Applications: Neutralization
  115. LRRC15 inhibits SARS-CoV-2 cellular entry in trans
    Authors: J Song, RD Chow, M Pena-Herna, L Zhang, SA Loeb, EY So, OD Liang, P Ren, S Chen, CB Wilen, S Lee
    PloS Biology, 2022-10-13;20(10):e3001805.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  116. The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation
    Authors: K Shilagardi, ED Spear, R Abraham, DE Griffin, S Michaelis
    MBio, 2022-10-05;0(0):e0254322.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  117. SARS-CoV-2 infects adipose tissue in a fat depot- and viral lineage-dependent manner
    Authors: TD Saccon, F Mousovich-, RG Ludwig, VC Carregari, AB Dos Anjos, ASC Dos Passos, MC Martini, PP Barbosa, GF de Souza, SP Muraro, J Forato, MR Amorim, RE Marques, FP Veras, E Barreto, TT Gonçalves, IM Paiva, NPB Fazolini, CMK Onodera, RB Martins Ju, PHC de Araújo, SS Batah, RMM Viana, DM de Melo, AT Fabro, E Arruda, F Queiroz Cu, TM Cunha, MAM Pretti, BJ Smith, H Marques-So, TL Knittel, GP Ruiz, GS Profeta, TCM Fontes-Cal, M Boroni, MAR Vinolo, AS Farias, PMM Moraes-Vie, JMA Bizzacchi, T Teesalu, FDM Chaim, E Cazzo, EA Chaim, JL Proença-Mó, D Martins-de, MK Osako, LO Leiria, MA Mori
    Nature Communications, 2022-09-29;13(1):5722.
    Species: African Green Monkey
    Sample Types: Whole Cells
    Applications: ICC
  118. Memory CD8+ T cell diversity and B cell responses correlate with protection against SARS-CoV-2 following mRNA vaccination
    Authors: N Brasu, I Elia, V Russo, G Montacchie, SA Stabile, C De Intinis, F Fesi, K Gizzi, M Macagno, M Montone, B Mussolin, A Grifoni, S Faravelli, S Marchese, F Forneris, R De Frances, A Sette, V Barnaba, A Sottile, A Sapino, L Pace
    Nature Immunology, 2022-09-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  119. Metalloprotease-Dependent S2'-Activation Promotes Cell-Cell Fusion and Syncytiation of SARS-CoV-2
    Authors: JV Harte, SL Wakerlin, AJ Lindsay, JV McCarthy, C Coleman-Va
    Viruses, 2022-09-21;14(10):.
  120. SARS-CoV-2 can infect human embryos
    Authors: M Montano, AR Victor, DK Griffin, T Duong, N Bolduc, A Farmer, V Garg, AK Hadjantona, A Coates, FL Barnes, CG Zouves, WC Greene, M Viotti
    Scientific Reports, 2022-09-14;12(1):15451.
    Species: Human
    Sample Types: Whole Cells
    Applications: Control, ICC
  121. Surface translocation of ACE2 and TMPRSS2 upon TLR4/7/8 activation is required for SARS-CoV-2 infection in circulating monocytes
    Authors: Y Yao, K Subedi, T Liu, N Khalasawi, CD Pretto-Ker, JW Wotring, J Wang, C Yin, A Jiang, C Fu, P Dimitrion, J Li, J Veenstra, Q Yi, K McKinnon, JE McKinnon, JZ Sexton, L Zhou, QS Mi
    Cell Discovery, 2022-09-09;8(1):89.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  122. Integrated multi-omics analyses identify key anti-viral host factors and pathways controlling SARS-CoV-2 infection
    Authors: J Hou, Y Wei, J Zou, R Jaffery, S Liang, C Zheng, K Chen, PY Shi, Y Chen, X Xie, W Peng
    Research square, 2022-08-15;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  123. Development of a novel peptide to prevent entry of SARS-CoV-2 into lung and olfactory bulb cells of hACE2 expressing mice
    Authors: P Su, D Zhai, AHC Wong, F Liu
    Molecular Brain, 2022-08-09;15(1):71.
    Species: Human, Mouse
    Sample Types: Cell Lysates, Whole Tissue
    Applications: Co-Immunoprecipitation, IHC, Western Blot
  124. SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity
    Authors: B Meng, R Datir, J Choi, CITIID-NIH, JR Bradley, KGC Smith, JH Lee, RK Gupta
    Cell Reports, 2022-08-03;40(7):111220.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  125. Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells
    Authors: Y Zhu, KY Chew, M Wu, AC Karawita, G McCallum, LE Steele, A Yamamoto, LI Labzin, T Yarlagadda, AA Khromykh, X Wang, JDJ Sng, CJ Stocks, Y Xia, TR Kollmann, D Martino, M Joensuu, FA Meunier, G Balistreri, H Bielefeldt, AC Bowen, A Kicic, PD Sly, KM Spann, KR Short
    PloS Biology, 2022-08-01;20(8):e3001728.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Western Blot
  126. Distinct airway epithelial immune responses after infection with SARS-CoV-2 compared to H1N1
    Authors: H Stölting, L Baillon, R Frise, K Bonner, RJ Hewitt, PL Molyneaux, ML Gore, Breathing, WS Barclay, S Saglani, CM Lloyd
    Mucosal Immunology, 2022-07-15;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  127. A Newly Engineered A549 Cell Line Expressing ACE2 and TMPRSS2 Is Highly Permissive to SARS-CoV-2, Including the Delta and Omicron Variants
    Authors: CW Chang, KM Parsi, M Somasundar, E Vanderleed, P Liu, J Cruz, A Cousineau, RW Finberg, EA Kurt-Jones
    Viruses, 2022-06-23;14(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  128. A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells
    Authors: Garreta E, Prado P, Stanifer ML et al.
    Cell Metabolism
  129. A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells
    Authors: Garreta E, Prado P, Stanifer ML et al.
    Cell Metabolism
  130. IgM anti-ACE2 autoantibodies in severe COVID-19 activate complement and perturb vascular endothelial function
    Authors: L Casciola-R, DR Thiemann, F Andrade, MI Trejo-Zamb, EK Leonard, JB Spangler, NE Skinner, J Bailey, S Yegnasubra, R Wang, AM Vaghasia, A Gupta, AL Cox, SC Ray, RM Linville, Z Guo, PC Searson, CE Machamer, S Desiderio, LM Sauer, O Laeyendeck, BT Garibaldi, L Gao, M Damarla, PM Hassoun, JE Hooper, CA Mecoli, L Christophe, L Gutierrez-, Q Yang, D Hines, WA Clarke, RE Rothman, A Pekosz, KZ Fenstermac, Z Wang, SL Zeger, A Rosen
    JCI Insight, 2022-05-09;7(9):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  131. FcgammaR-mediated SARS-CoV-2 infection of monocytes activates inflammation
    Authors: C Junqueira, Â Crespo, S Ranjbar, LB de Lacerda, M Lewandrows, J Ingber, B Parry, S Ravid, S Clark, MR Schrimpf, F Ho, C Beakes, J Margolin, N Russell, K Kays, J Boucau, U Das Adhika, SM Vora, V Leger, L Gehrke, L Henderson, E Janssen, D Kwon, C Sander, J Abraham, MB Goldberg, H Wu, G Mehta, S Bell, AE Goldfeld, MR Filbin, J Lieberman
    Nature, 2022-04-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry, Neutralization
  132. Two Different Therapeutic Approaches for SARS-CoV-2 in hiPSCs-Derived Lung Organoids
    Authors: P Spitalieri, F Centofanti, M Murdocca, MG Scioli, A Latini, S Di Cesare, G Citro, A Rossi, A Orlandi, S Miersch, SS Sidhu, PP Pandolfi, A Botta, F Sangiuolo, G Novelli
    Cells, 2022-04-05;11(7):.
    Species: Human
    Sample Types: Organoid
    Applications: IHC
  133. ACE2 Receptor and Its Isoform Short-ACE2 Are Expressed on Human Spermatozoa
    Authors: M Ramal-Sanc, C Castellini, C Cimini, A Taraschi, L Valbonetti, A Barbonetti, N Bernabò, B Barboni
    International Journal of Molecular Sciences, 2022-03-28;23(7):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  134. SARS-CoV-2 infects and replicates in photoreceptor and retinal ganglion cells of human retinal organoids
    Authors: Y Menuchin-L, A Schreiber, A Lecanda, A Mecate-Zam, L Brunotte, OE Psathaki, S Ludwig, T Rauen, HR Schöler
    Stem Cell Reports, 2022-03-24;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: Neutralization
  135. Diltiazem inhibits SARS-CoV-2 cell attachment and internalization and decreases the viral infection in mouse lung
    Authors: X Wang, J Luo, Z Wen, L Shuai, C Wang, G Zhong, X He, H Cao, R Liu, J Ge, R Hua, Z Sun, X Wang, J Wang, Z Bu
    PloS Pathogens, 2022-02-17;18(2):e1010343.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  136. The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2
    Authors: S Krasemann, U Haferkamp, S Pfefferle, MS Woo, F Heinrich, M Schweizer, A Appelt-Men, A Cubukova, J Barenberg, J Leu, K Hartmann, E Thies, JL Littau, D Sepulveda-, L Zhang, K Ton, Y Liang, J Matschke, F Ricklefs, T Sauvigny, J Sperhake, A Fitzek, A Gerhartl, A Brachner, N Geiger, EM König, J Bodem, S Franzenbur, A Franke, S Moese, FJ Müller, G Geisslinge, C Claussen, A Kannt, A Zaliani, P Gribbon, B Ondruschka, W Neuhaus, MA Friese, M Glatzel, O Pless
    Stem Cell Reports, 2022-01-20;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  137. Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2
    Authors: L El-Shennaw, AD Hoffmann, NK Dashzeveg, KM McAndrews, PJ Mehl, D Cornish, Z Yu, VL Tokars, V Nicolaescu, A Tomatsidou, C Mao, CJ Felicelli, CF Tsai, C Ostiguin, Y Jia, L Li, K Furlong, J Wysocki, X Luo, CF Ruivo, D Batlle, TJ Hope, Y Shen, YK Chae, H Zhang, VS LeBleu, T Shi, S Swaminatha, Y Luo, D Missiakas, GC Randall, AR Demonbreun, MG Ison, R Kalluri, D Fang, H Liu
    Nature Communications, 2022-01-20;13(1):405.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  138. Evaluation of SARS-CoV-2 entry, inflammation and new therapeutics in human lung tissue cells
    Authors: J Grau-Expós, D Perea, M Suppi, N Massana, A Vergara, MJ Soler, B Trinite, J Blanco, J García-Pér, J Alcamí, A Serrano-Mo, J Rosado, V Falcó, M Genescà, MJ Buzon
    PloS Pathogens, 2022-01-13;18(1):e1010171.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  139. Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations
    Authors: L Helms, S Marchiano, IB Stanaway, TY Hsiang, BA Juliar, S Saini, YT Zhao, A Khanna, R Menon, F Alakwaa, C Mikacenic, ED Morrell, MM Wurfel, M Kretzler, JL Harder, CE Murry, J Himmelfarb, H Ruohola-Ba, PK Bhatraju, M Gale, BS Freedman
    JCI Insight, 2021-12-22;0(0):.
    Species: Human
    Sample Types: Organoids
    Applications: IHC
  140. SARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells
    Authors: J Wang, G Yang, X Wang, Z Wen, L Shuai, J Luo, C Wang, Z Sun, R Liu, J Ge, X He, R Hua, X Wang, X Yang, W Chen, G Zhong, Z Bu
    Cell Discovery, 2021-12-14;7(1):119.
    Species: Human, Primate - C. aethiops
    Sample Types: Whole Cells
    Applications: Flow Cytometry, Neutralization
  141. SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-beta signaling
    Authors: SB Biering, FTG de Sousa, LV Tjang, F Pahmeier, R Ruan, SF Blanc, TS Patel, CM Worthingto, DR Glasner, B Castillo-R, V Servellita, NTN Lo, MP Wong, CM Warnes, DR Sandoval, TM Clausen, YA Santos, V Ortega, HC Aguilar, JD Esko, CY Chui, JE Pak, PR Beatty, E Harris
    bioRxiv : the preprint server for biology, 2021-12-13;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  142. Receptor-Binding Domain Proteins of SARS-CoV-2 Variants Elicited Robust Antibody Responses Cross-Reacting with Wild-Type and Mutant Viruses in Mice
    Authors: J Shi, X Jin, Y Ding, X Liu, A Shen, Y Wu, M Peng, C Shen
    Vaccines, 2021-11-24;9(12):.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA Detection
  143. Sialic acid-containing glycolipids mediate binding and viral entry of SARS-CoV-2
    Authors: L Nguyen, KA McCord, DT Bui, KM Bouwman, EN Kitova, M Elaish, D Kumawat, GC Daskhan, I Tomris, L Han, P Chopra, TJ Yang, SD Willows, AL Mason, LK Mahal, TL Lowary, LJ West, SD Hsu, T Hobman, SM Tompkins, GJ Boons, RP de Vries, MS Macauley, JS Klassen
    Nature Chemical Biology, 2021-11-09;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  144. Brain Cross-Protection against SARS-CoV-2 Variants by a Lentiviral Vaccine in New Transgenic Mice
    Authors: MW Ku, P Authié, M Bourgine, F Anna, A Noirat, F Moncoq, B Vesin, F Nevo, J Lopez, P Souque, C Blanc, I Fert, S Chardenoux, L Lafosse, D Cussigh, D Hardy, K Nemirov, F Guinet, F Langa Vive, L Majlessi, P Charneau
    Embo Molecular Medicine, 2021-10-25;0(0):e14459.
    Species: Transgenic Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  145. An airway organoid-based screen identifies a role for the HIF1alpha-glycolysis axis in SARS-CoV-2 infection
    Authors: X Duan, X Tang, MS Nair, T Zhang, Y Qiu, W Zhang, P Wang, Y Huang, J Xiang, H Wang, RE Schwartz, DD Ho, T Evans, S Chen
    Cell Reports, 2021-10-15;37(6):109920.
    Species: Human
    Sample Types: Organoids
    Applications: IHC
  146. SARS-CoV-2 and its variants of concern infect human conjunctival epithelial cells and induce differential antiviral innate immune response
    Authors: S Singh, G Garcia, R Shah, AA Kramerov, RE Wright, TM Spektor, AV Ljubimov, V Arumugaswa, A Kumar
    The ocular surface, 2021-09-25;0(0):.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  147. BRD2 inhibition blocks SARS-CoV-2 infection in vitro by reducing transcription of the host cell receptor ACE2
    Authors: R Tian, AJ Samelson, VV Rezelj, M Chen, GN Ramadoss, X Guo, AM Kain, QD Tran, SA Lim, I Lui, J Nunez, SJ Rockwood, N Liu, J Carlson-St, J Oki, T Maures, K Holden, JS Weissman, JA Wells, B Conklin, M Vignuzzi, M Kampmann
    bioRxiv : the preprint server for biology, 2021-09-20;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  148. "Molecular Masks" for ACE2 to Effectively and Safely Block SARS-CoV-2 Virus Entry
    Authors: SP Shukla, KB Cho, V Rustagi, X Gao, X Fu, SX Zhang, B Guo, DG Udugamasoo
    International Journal of Molecular Sciences, 2021-08-20;22(16):.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: Flow Cytometry, Western Blot
  149. ACE2 protein expression within isogenic cell lines is heterogeneous and associated with distinct transcriptomes
    Authors: EJ Sherman, BT Emmer
    Scientific Reports, 2021-08-05;11(1):15900.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: Western Blot, Flow Cytometry
  150. Signatures in SARS-CoV-2 spike protein conferring escape to neutralizing antibodies
    Authors: M Alenquer, F Ferreira, D Lousa, M Valério, M Medina-Lop, ML Bergman, J Gonçalves, J Demengeot, RB Leite, J Lilue, Z Ning, C Penha-Gonç, H Soares, CM Soares, MJ Amorim
    PloS Pathogens, 2021-08-05;17(8):e1009772.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  151. L-SIGN is a receptor on liver sinusoidal endothelial cells for SARS-CoV-2 virus
    Authors: Y Kondo, JL Larabee, L Gao, H Shi, B Shao, CM Hoover, JM McDaniel, YC Ho, R Silasi-Man, SA Archer-Har, P Azadi, RS Srinivasan, AR Rezaie, A Borczuk, JC Laurence, F Lupu, J Ahamed, RP McEver, JF Papin, Z Yu, L Xia
    JCI Insight, 2021-07-22;6(14):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  152. Cigarette Smoke Stimulates SARS-CoV-2 Internalization by Activating AhR and Increasing ACE2 Expression in Human Gingival Epithelial Cells
    Authors: CLC Almeida-da, H Matshik Da, K Liu, DM Ojcius
    International Journal of Molecular Sciences, 2021-07-18;22(14):.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Western Blot
  153. A human three-dimensional neural-perivascular 'assembloid' promotes astrocytic development and enables modeling of SARS-CoV-2 neuropathology
    Authors: L Wang, D Sievert, AE Clark, S Lee, H Federman, BD Gastfriend, EV Shusta, SP Palecek, AF Carlin, JG Gleeson
    Nature Medicine, 2021-07-09;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: IHC
  154. Rapid, reliable, and reproducible cell fusion assay to quantify SARS-Cov-2 spike interaction with hACE2
    Authors: M Zhao, PY Su, DA Castro, TN Tripler, Y Hu, M Cook, AI Ko, SF Farhadian, B Israelow, CS Dela Cruz, Y Xiong, RE Sutton, Yale IMPAC
    PloS Pathogens, 2021-06-24;17(6):e1009683.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  155. Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
    Authors: M Puray-Chav, KM LaPak, TP Schrank, JL Elliott, DP Bhatt, MJ Agajanian, R Jasuja, DQ Lawson, K Davis, PW Rothlauf, Z Liu, H Jo, N Lee, K Tenneti, JE Eschbach, C Shema Mugi, EM Cousins, EW Cloer, HR Vuong, LA VanBlargan, AL Bailey, P Gilchuk, JE Crowe, MS Diamond, DN Hayes, SPJ Whelan, A Horani, SL Brody, D Goldfarb, MB Major, SB Kutluay
    Cell Reports, 2021-06-23;0(0):109364.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  156. Deletion of ER-retention motif on SARS-CoV-2 spike protein reduces cell hybrid during cell-cell fusion
    Authors: X Wang, CH Chen, S Badeti, JH Cho, A Naghizadeh, Z Wang, D Liu
    Cell & bioscience, 2021-06-23;11(1):114.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  157. Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes
    Authors: M Baratchian, JM McManus, MP Berk, F Nakamura, S Mukhopadhy, W Xu, S Erzurum, J Drazba, J Peterson, EA Klein, B Gaston, N Sharifi
    Scientific Reports, 2021-05-27;11(1):11130.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  158. Direct derivation of human alveolospheres for SARS-CoV-2 infection modeling and drug screening
    Authors: T Ebisudani, S Sugimoto, K Haga, A Mitsuishi, R Takai-Toda, M Fujii, K Toshimitsu, J Hamamoto, K Sugihara, T Hishida, H Asamura, K Fukunaga, H Yasuda, K Katayama, T Sato
    Cell Reports, 2021-05-19;0(0):109218.
    Species: Human
    Sample Types: Whole Tissue
    Applications: ICC
  159. SARS-CoV-2 infects human adult donor eyes and hESC-derived ocular epithelium
    Authors: AZ Eriksen, R Møller, B Makovoz, SA Uhl, BR tenOever, TA Blenkinsop
    Cell Stem Cell, 2021-05-17;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  160. Deletion of ER-retention Motif on SARS-CoV-2 Spike Protein Reduces Cell Hybrid During Cell-cell Fusion
    Authors: CH Chen, S Badeti, JH Cho, A Naghizadeh, X Wang, D Liu
    Research square, 2021-04-09;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry, ICC
  161. Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2
    Authors: M Dittmar, JS Lee, K Whig, E Segrist, M Li, B Kamalia, L Castellana, K Ayyanathan, FL Cardenas-D, EE Morrisey, R Truitt, W Yang, K Jurado, K Samby, H Ramage, DC Schultz, S Cherry
    Cell Reports, 2021-03-23;35(1):108959.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  162. Characterisation of B.1.1.7 and Pangolin coronavirus spike provides insights on the evolutionary trajectory of SARS-CoV-2
    Authors: SJ Dicken, MJ Murray, LG Thorne, AK Reuschl, C Forrest, M Ganeshalin, L Muir, MD Kalemera, M Palor, LE McCoy, C Jolly, GJ Towers, MB Reeves, J Grove
    bioRxiv : the preprint server for biology, 2021-03-22;0(0):.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: Flow Cytometry, Western Blot
  163. SARS-CoV-2 hijacks folate and one-carbon metabolism for viral replication
    Authors: Y Zhang, R Guo, SH Kim, H Shah, S Zhang, JH Liang, Y Fang, M Gentili, CNO Leary, SJ Elledge, DT Hung, VK Mootha, BE Gewurz
    Nature Communications, 2021-03-15;12(1):1676.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  164. MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2
    Authors: K Uemura, M Sasaki, T Sanaki, S Toba, Y Takahashi, Y Orba, WW Hall, K Maenaka, H Sawa, A Sato
    Scientific Reports, 2021-03-08;11(1):5376.
    Species: Human, Primate
    Sample Types: Whole Cells
    Applications: Flow Cytometry, ICC
  165. Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2
    Authors: J Baggen, L Persoons, E Vanstreels, S Jansen, D Van Loover, B Boeckx, V Geudens, J De Man, D Jochmans, J Wauters, E Wauters, BM Vanaudenae, D Lambrechts, J Neyts, K Dallmeier, HJ Thibaut, M Jacquemyn, P Maes, D Daelemans
    Nature Genetics, 2021-03-08;0(0):.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: Flow Cytometry, Simple Western
  166. Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease
    Authors: EE Khoury, Y Knaney, A Fokra, S Kinaneh, Z Azzam, SN Heyman, Z Abassi
    Journal of Cellular and Molecular Medicine, 2021-03-04;0(0):.
    Species: Rat
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC
  167. An organoid-based organ-repurposing approach to treat short bowel syndrome
    Authors: S Sugimoto, E Kobayashi, M Fujii, Y Ohta, K Arai, M Matano, K Ishikawa, K Miyamoto, K Toshimitsu, S Takahashi, K Nanki, Y Hakamata, T Kanai, T Sato
    Nature, 2021-02-24;0(0):.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  168. Human Erythroid Progenitors Are Directly Infected by SARS-CoV-2: Implications for Emerging Erythropoiesis in Severe COVID-19 Patients
    Authors: H Huerga Enc, W Grey, M Garcia-Alb, H Wood, R Ulferts, IV Aramburu, AG Kulasekara, G Mufti, V Papayannop, R Beale, D Bonnet
    Stem Cell Reports, 2021-02-05;16(3):428-436.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry, ICC
  169. MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells
    Authors: X Yin, L Riva, Y Pu, L Martin-San, J Kanamune, Y Yamamoto, K Sakai, S Gotoh, L Miorin, PD De Jesus, CC Yang, KM Herbert, S Yoh, JF Hultquist, A García-Sas, SK Chanda
    Cell Reports, 2021-01-12;34(2):108628.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  170. A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection
    Authors: C Blume, CL Jackson, CM Spalluto, J Legebeke, L Nazlamova, F Conforti, JM Perotin, M Frank, J Butler, M Crispin, J Coles, J Thompson, RA Ridley, LSN Dean, M Loxham, S Reikine, A Azim, K Tariq, DA Johnston, PJ Skipp, R Djukanovic, D Baralle, CJ McCormick, DE Davies, JS Lucas, G Wheway, V Mennella
    Nature Genetics, 2021-01-11;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  171. Host and viral determinants for efficient SARS-CoV-2 infection of the human lung
    Authors: H Chu, B Hu, X Huang, Y Chai, D Zhou, Y Wang, H Shuai, D Yang, Y Hou, X Zhang, TT Yuen, JP Cai, AJ Zhang, J Zhou, S Yuan, KK To, IH Chan, KY Sit, DC Foo, IY Wong, AT Ng, TT Cheung, SY Law, WK Au, MA Brindley, Z Chen, KH Kok, JF Chan, KY Yuen
    Nature Communications, 2021-01-08;12(1):134.
    Species: Mesocricetus auratus (Hamster)
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  172. SARS-CoV-2 induces human plasmacytoid pre-dendritic cell diversification via UNC93B and IRAK4
    Authors: F Onodi, L Bonnet-Mad, L Meertens, L Karpf, J Poirot, SY Zhang, C Picard, A Puel, E Jouanguy, Q Zhang, J Le Goff, JM Molina, C Delaugerre, JL Casanova, A Amara, V Soumelis
    bioRxiv : the preprint server for biology, 2021-01-08;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  173. SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site
    Authors: AZ Mykytyn, TI Breugem, S Riesebosch, D Schipper, PB van den Do, RJ Rottier, MM Lamers, BL Haagmans
    Elife, 2021-01-04;10(0):.
    Species: Human
    Sample Types: Whole Cells, Whole Tissue
    Applications: ICC, IHC
  174. Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men
    Authors: RM Samuel, H Majd, MN Richter, Z Ghazizadeh, SM Zekavat, A Navickas, JT Ramirez, H Asgharian, CR Simoneau, LR Bonser, KD Koh, M Garcia-Kni, M Tassetto, S Sunshine, S Farahvashi, A Kalantari, W Liu, R Andino, H Zhao, P Natarajan, DJ Erle, M Ott, H Goodarzi, F Fattahi
    Cell Stem Cell, 2020-11-17;27(6):876-889.e12.
    Species: Human
    Sample Types: Organoid
    Applications: ICC
  175. Goblet Cell Hyperplasia Increases SARS-CoV-2 Infection in COPD
    Authors: JK Osan, SN Talukdar, F Feldmann, B Ann DeMont, K Jerome, KL Bailey, H Feldmann, M Mehedi
    bioRxiv, 2020-11-12;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  176. Effective screening of SARS-CoV-2 neutralizing antibodies in patient serum using lentivirus particles pseudotyped with SARS-CoV-2 spike glycoprotein
    Authors: R Tandon, D Mitra, P Sharma, MG McCandless, SJ Stray, JT Bates, GD Marshall
    Sci Rep, 2020-11-05;10(1):19076.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  177. ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs
    Authors: IT Lee, T Nakayama, CT Wu, Y Goltsev, S Jiang, PA Gall, CK Liao, LC Shih, CM Schürch, DR McIlwain, P Chu, NA Borchard, D Zarabanda, SS Dholakia, A Yang, D Kim, H Chen, T Kanie, CD Lin, MH Tsai, KM Phillips, R Kim, JB Overdevest, MA Tyler, CH Yan, CF Lin, YT Lin, DT Bau, GJ Tsay, ZM Patel, YA Tsou, A Tzankov, MS Matter, CJ Tai, TH Yeh, PH Hwang, GP Nolan, JV Nayak, PK Jackson
    Nat Commun, 2020-10-28;11(1):5453.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  178. SARS-CoV-2 Mpro inhibitors and activity-based probes for patient-sample imaging
    Authors: W Rut, K Groborz, L Zhang, X Sun, M Zmudzinski, B Pawlik, X Wang, D Jochmans, J Neyts, W M?ynarski, R Hilgenfeld, M Drag
    Nat Chem Biol, 2020-10-22;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  179. IgM autoantibodies recognizing ACE2 are associated with severe COVID-19
    Authors: L Casciola-R, DR Thiemann, F Andrade, MI Trejo Zamb, JE Hooper, E Leonard, J Spangler, AL Cox, C Machamer, L Sauer, O Laeyendeck, BT Garibaldi, SC Ray, C Mecoli, L Christophe, L Gutierrez-, Q Yang, D Hines, W Clarke, RE Rothman, A Pekosz, K Fenstermac, Z Wang, SL Zeger, A Rosen
    medRxiv, 2020-10-15;0(0):.
    Species: Human
    Sample Types: Protein
    Applications: Western Blot
  180. A nanoluciferase SARS-CoV-2 for rapid neutralization testing and screening of anti-infective drugs for COVID-19
    Authors: X Xie, AE Muruato, X Zhang, KG Lokugamage, CR Fontes-Gar, J Zou, J Liu, P Ren, M Balakrishn, T Cihlar, CK Tseng, S Makino, VD Menachery, JP Bilello, PY Shi
    Nat Commun, 2020-10-15;11(1):5214.
    Species: Primate
    Sample Types: Whole Cells
    Applications: ICC, Neutralization
  181. Sex, androgens and regulation of pulmonary AR, TMPRSS2 and ACE2
    Authors: M Baratchian, JM McManus, M Berk, F Nakamura, S Mukhopadhy, W Xu, S Erzurum, J Drazba, J Peterson, EA Klein, B Gaston, N Sharifi
    bioRxiv, 2020-10-14;0(0):.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  182. SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids
    Authors: L Pellegrini, A Albecka, DL Mallery, MJ Kellner, D Paul, AP Carter, LC James, MA Lancaster
    Cell Stem Cell, 2020-10-13;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  183. Type 2 and interferon inflammation regulate SARS-CoV-2 entry factor expression in the airway epithelium
    Authors: SP Sajuthi, P DeFord, Y Li, ND Jackson, MT Montgomery, JL Everman, CL Rios, E Pruesse, JD Nolin, EG Plender, ME Wechsler, ACY Mak, C Eng, S Salazar, V Medina, EM Wohlford, S Huntsman, DA Nickerson, S Germer, MC Zody, G Abecasis, HM Kang, KM Rice, R Kumar, S Oh, J Rodriguez-, EG Burchard, MA Seibold
    Nat Commun, 2020-10-12;11(1):5139.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  184. Functional genomic screens identify human host factors for SARS-CoV-2 and common cold coronaviruses
    Authors: R Wang, CR Simoneau, J Kulsuptrak, M Bouhaddou, K Travisano, JM Hayashi, J Carlson-St, J Oki, K Holden, NJ Krogan, M Ott, AS Puschnik
    bioRxiv : the preprint server for biology, 2020-09-24;0(0):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  185. SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response
    Authors: J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta, KD Alysandrat, ML Beermann, C Simone-Roa, J Lindstrom-, J Olejnik, EL Suder, E Bullitt, A Hinds, A Sharma, M Bosmann, R Wang, F Hawkins, EJ Burks, M Saeed, AA Wilson, E Mühlberger, DN Kotton
    Cell Stem Cell, 2020-09-18;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry, ICC
  186. Modeling COVID-19 with Human Pluripotent Stem Cell-Derived Cells Reveals Synergistic Effects of Anti-inflammatory Macrophages with ACE2 Inhibition Against SARS-CoV-2
    Authors: F Duan, L Guo, L Yang, Y Han, A Thakur, BE Nilsson-Pa, P Wang, Z Zhang, CY Ma, X Zhou, T Han, T Zhang, X Wang, D Xu, X Duan, J Xiang, HF Tse, C Liao, W Luo, FP Huang, YW Chen, T Evans, RE Schwartz, B tenOever, DD Ho, S Chen, Q Lian, HJ Chen
    Res Sq, 2020-09-15;0(0):.
    Species: Human, Mouse
    Sample Types: Whole Cells, Whole Tissue
    Applications: IHC, Neutralization
  187. Antiviral Activity of Type I, II, and III Interferons Counterbalances ACE2 Inducibility and Restricts SARS-CoV-2
    Authors: I Busnadiego, S Fernbach, MO Pohl, U Karakus, M Huber, A Trkola, S Stertz, BG Hale
    MBio, 2020-09-10;11(5):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  188. Neuroinvasion of SARS-CoV-2 in human and mouse brain
    Authors: E Song, C Zhang, B Israelow, A Lu-Culliga, AV Prado, S Skriabine, P Lu, OE Weizman, F Liu, Y Dai, K Szigeti-Bu, Y Yasumoto, G Wang, C Castaldi, J Heltke, E Ng, J Wheeler, MM Alfajaro, E Levavasseu, B Fontes, NG Ravindra, D Van Dijk, S Mane, M Gunel, A Ring, SA Jaffar Kaz, K Zhang, CB Wilen, TL Horvath, I Plu, S Haik, JL Thomas, A Louvi, SF Farhadian, A Huttner, D Seilhean, N Renier, K Bilguvar, A Iwasaki
    bioRxiv : the preprint server for biology, 2020-09-08;0(0):.
    Species: Human
    Sample Types: Organoid
    Applications: Neutralization
  189. Implications for SARS-CoV-2 Vaccine Design: Fusion of Spike Glycoprotein Transmembrane Domain to Receptor-Binding Domain Induces Trimerization
    Authors: T Azad, R Singaravel, MJF Crupi, T Jamieson, J Dave, EEF Brown, R Rezaei, Z Taha, S Boulton, NT Martin, A Surendran, J Poutou, M Ghahremani, K Nouri, JT Whelan, J Duong, S Tucker, JS Diallo, JC Bell, CS Ilkow
    Membranes (Basel), 2020-08-30;10(9):.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  190. SARS-CoV-2 Infection of Pluripotent Stem Cell-derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response
    Authors: J Huang, AJ Hume, KM Abo, RB Werder, C Villacorta, KD Alysandrat, ML Beermann, C Simone-Roa, J Olejnik, EL Suder, E Bullitt, A Hinds, A Sharma, M Bosmann, R Wang, F Hawkins, EJ Burks, M Saeed, AA Wilson, E Mühlberger, DN Kotton
    bioRxiv, 2020-08-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry, ICC
  191. Cross-sectional evaluation of humoral responses against SARS-CoV-2 Spike
    Authors: J Prévost, R Gasser, G Beaudoin-B, J Richard, R Duerr, A Laumaea, SP Anand, G Goyette, S Ding, H Medjahed, A Lewin, J Perreault, T Tremblay, G Gendron-Le, N Gauthier, M Carrier, D Marcoux, A Piché, M Lavoie, A Benoit, V Loungnarat, G Brochu, M Desforges, PJ Talbot, GT Gould Maul, M Côté, C Therrien, B Serhir, R Bazin, M Roger, A Finzi
    bioRxiv : the preprint server for biology, 2020-07-30;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  192. Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection
    Authors: R Rathnasing, S Strohmeier, F Amanat, VL Gillespie, F Krammer, A García-Sas, L Coughlan, M Schotsaert, M Uccellini
    bioRxiv, 2020-07-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  193. Co-expression of SARS-CoV-2 entry genes in the superficial adult human conjunctival, limbal and corneal epithelium suggests an additional route of entry via the ocular surface
    Authors: J Collin, R Queen, D Zerti, B Dorgau, M Georgiou, I Djidrovski, R Hussain, JM Coxhead, A Joseph, P Rooney, S Lisgo, F Figueiredo, L Armstrong, M Lako
    Ocul Surf, 2020-06-03;0(0):.
    Species: Human
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  194. Infection of bat and human intestinal organoids by SARS-CoV-2
    Authors: J Zhou, C Li, X Liu, MC Chiu, X Zhao, D Wang, Y Wei, A Lee, AJ Zhang, H Chu, JP Cai, CC Yip, IH Chan, KK Wong, OT Tsang, KH Chan, JF Chan, KK To, H Chen, KY Yuen
    Nat. Med., 2020-05-13;0(0):.
    Species: Bat, Human
    Sample Types: Whole Cells
    Applications: ICC
  195. Robust ACE2 protein expression localizes to the motile cilia of the respiratory tract epithelia and is not increased by ACE inhibitors or angiotensin receptor blockers
    Authors: IT Lee, T Nakayama, CT Wu, Y Goltsev, S Jiang, PA Gall, CK Liao, LC Shih, CM Schurch, DR McIlwain, P Chu, NA Borchard, D Zarabanda, SS Dholakia, A Yang, D Kim, T Kanie, CD Lin, MH Tsai, KM Phillips, R Kim, JB Overdevest, MA Tyler, CH Yan, CF Lin, YT Lin, DT Bau, GJ Tsay, ZM Patel, YA Tsou, CJ Tai, TH Yeh, PH Hwang, GP Nolan, JV Nayak, PK Jackson
    medRxiv, 2020-05-12;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  196. Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays
    Authors: KHD Crawford, R Eguia, AS Dingens, AN Loes, KD Malone, CR Wolf, HY Chu, MA Tortorici, D Veesler, M Murphy, D Pettie, NP King, AB Balazs, JD Bloom
    Viruses, 2020-05-06;12(5):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  197. Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids
    Authors: Y Han, L Yang, X Duan, F Duan, BE Nilsson-Pa, TM Yaron, P Wang, X Tang, T Zhang, Z Zhao, Y Bram, D Redmond, S Houghton, D Nguyen, D Xu, X Wang, S Uhl, Y Huang, JL Johnson, J Xiang, H Wang, FC Pan, LC Cantley, BR tenOever, DD Ho, T Evans, RE Schwartz, HJ Chen, S Chen
    bioRxiv, 2020-05-05;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  198. Liraglutide Attenuates Non-Alcoholic Fatty Liver Disease in Mice by Regulating the Local Renin-Angiotensin System
    Authors: M Yang, X Ma, X Xuan, H Deng, Q Chen, L Yuan
    Front Pharmacol, 2020-04-08;11(0):432.
    Species: Human, Mouse
    Sample Types: Cell Lysates, Tissue Homogenates
    Applications: Western Blot
  199. SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.
    Authors: Hoffmann M, Kleine-Weber H, Schroeder S, Kruger N, Herrler T, Erichsen S, Schiergens T, Herrler G, Wu N, Nitsche A, Muller M, Drosten C, Pohlmann S
    Cell, 2020-03-05;181(0):1-10.
    Species: Primate - Chlorocebus aethiops (African Green Monkey)
    Sample Types: Whole Cells
    Applications: Neutralization
  200. Protective effects of the Francisella tularensis δpdpC mutant against its virulent parental strain SCHU P9 in Cynomolgus macaques
    Authors: D Tian, A Uda, Y Ami, A Hotta, ES Park, N Nagata, N Iwata-Yosh, A Yamada, K Hirayama, K Miura, Y Koyama, M Azaki, S Morikawa
    Sci Rep, 2019-06-24;9(1):9193.
    Species: Rhesus Macaca (Macaque)
    Sample Types: Whole Tissue
    Applications: IHC-P
  201. Translation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNA
    Authors: E Schrom, M Huber, M Aneja, C Dohmen, D Emrich, J Geiger, G Hasenpusch, A Herrmann-J, V Kretzschma, O Mykhailyk, T Pasewald, P Oak, A Hilgendorf, D Wohlleber, HG Hoymann, D Schaudien, C Plank, C Rudolph, R Kubisch-Do
    Mol Ther Nucleic Acids, 2017-04-13;7(0):350-365.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: Flow Cytometry, Western Blot
  202. Protein Kinase C-? Mediates Shedding of Angiotensin-Converting Enzyme 2 from Proximal Tubular Cells.
    Authors: Fengxia Xiao, Joseph Zimpelman, Dylan Burger, Christopher Kennedy, Richard L Hébert, Kevin D Burns
    Frontiers in Pharmacology, 2016-06-01;0(0):1663-9812.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: Western Blot
  203. HTCC: Broad Range Inhibitor of Coronavirus Entry
    Authors: Aleksandra Milewska
    PLoS ONE, 2016-06-01;11(6):e0156552.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Whole Cells
    Applications: IHC
  204. Surface vimentin is critical for the cell entry of SARS-CoV.
    Authors: Yu Y, Chien S, Chen I, Lai C, Tsay Y, Chang S, Chang M
    J Biomed Sci, 2016-01-22;23(1):14.
    Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
    Sample Types: Whole Cells
    Applications: Neutralization
  205. Characterization of angiotensin-converting enzyme 2 ectodomain shedding from mouse proximal tubular cells.
    Authors: Xiao F, Zimpelmann J, Agaybi S, Gurley S, Puente L, Burns K
    PLoS ONE, 2014-01-15;9(1):e85958.
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  206. In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East Respiratory Syndrome (MERS) Coronavirus infection.
    Authors: Eckerle I, Muller M, Kallies S, Gotthardt D, Drosten C
    Virol J, 2013-12-23;10(0):359.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  207. TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.
    Authors: Heurich A, Hofmann-Winkler H, Gierer S, Liepold T, Jahn O, Pohlmann S
    J Virol, 2013-11-13;88(2):1293-307.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  208. Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor.
    Authors: Ge, Xing-Yi, Li, Jia-Lu, Yang, Xing-Lou, Chmura, Aleksei, Zhu, Guangjia, Epstein, Jonathan, Mazet, Jonna K, Hu, Ben, Zhang, Wei, Peng, Cheng, Zhang, Yu-Ji, Luo, Chu-Ming, Tan, Bing, Wang, Ning, Zhu, Yan, Crameri, Gary, Zhang, Shu-Yi, Wang, Lin-Fa, Daszak, Peter, Shi, Zheng-Li
    Nature, 2013-10-30;503(7477):535-8.
    Species: Bat, Civet, Human
    Sample Types: Whole Cells
    Applications: IHC
  209. Influenza and SARS-coronavirus activating proteases TMPRSS2 and HAT are expressed at multiple sites in human respiratory and gastrointestinal tracts.
    Authors: Bertram S, Heurich A, Lavender H, Gierer S, Danisch S, Perin P, Lucas JM, Nelson PS, Pohlmann S, Soilleux EJ
    PLoS ONE, 2012-04-30;7(4):e35876.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  210. Intrarenal renin angiotensin system revisited: role of megalin-dependent endocytosis along the proximal nephron.
    Authors: Pohl M, Kaminski H, Castrop H, Bader M, Himmerkus N, Bleich M, Bachmann S, Theilig F
    J. Biol. Chem., 2010-10-21;285(53):41935-46.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC-Fr, Western Blot
  211. Importance of cholesterol-rich membrane microdomains in the interaction of the S protein of SARS-coronavirus with the cellular receptor angiotensin-converting enzyme 2.
    Authors: Glende J, Schwegmann-Wessels C, Al-Falah M, Pfefferle S, Qu X, Deng H, Drosten C, Naim HY, Herrler G
    Virology, 2008-09-23;381(2):215-21.
    Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
    Sample Types: Cell Lysates
    Applications: Western Blot
  212. Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system.
    Authors: Epelman S, Tang WH, Chen SY, Van Lente F, Francis GS, Sen S
    J. Am. Coll. Cardiol., 2008-08-26;52(9):750-4.
    Species: Human
    Sample Types: Plasma
    Applications: Neutralization
  213. Lipid rafts are involved in SARS-CoV entry into Vero E6 cells.
    Authors: Lu Y, Liu DX, Tam JP
    Biochem. Biophys. Res. Commun., 2008-02-13;369(2):344-9.
    Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  214. Difference in receptor usage between severe acute respiratory syndrome (SARS) coronavirus and SARS-like coronavirus of bat origin.
    Authors: Ren W, Qu X, Li W, Han Z, Yu M, Zhou P, Zhang SY, Wang LF, Deng H, Shi Z
    J. Virol., 2007-12-12;82(4):1899-907.
    Species: Human
    Sample Types: Cell Lysates, Whole Cells
    Applications: ICC, Western Blot
  215. Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted.
    Authors: Inoue Y, Tanaka N, Tanaka Y, Inoue S, Morita K, Zhuang M, Hattori T, Sugamura K
    J. Virol., 2007-05-23;81(16):8722-9.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Cell Lysates
    Applications: Western Blot
  216. Synthetic reconstruction of zoonotic and early human severe acute respiratory syndrome coronavirus isolates that produce fatal disease in aged mice.
    Authors: Rockx B, Sheahan T, Donaldson E, Harkema J, Sims A, Heise M, Pickles R, Cameron M, Kelvin D, Baric R
    J. Virol., 2007-05-16;81(14):7410-23.
    Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
    Sample Types: Whole Cells
    Applications: Neutralization
  217. Interferon-gamma and interleukin-4 downregulate expression of the SARS coronavirus receptor ACE2 in Vero E6 cells.
    Authors: de Lang A, Osterhaus AD, Haagmans BL
    Virology, 2006-07-24;353(2):474-81.
    Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
    Sample Types: Whole Cells
    Applications: ICC
  218. Apical entry and release of severe acute respiratory syndrome-associated coronavirus in polarized Calu-3 lung epithelial cells.
    Authors: Tseng CT, Tseng J, Perrone L, Worthy M, Popov V, Peters CJ
    J. Virol., 2005-08-01;79(15):9470-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC, Neutralization
  219. Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor.
    Authors: Hofmann H, Geier M, Marzi A, Krumbiegel M, Peipp M, Fey GH, Gramberg T, Pohlmann S
    Biochem. Biophys. Res. Commun., 2004-07-09;319(4):1216-21.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  220. Multimerization- and glycosylation-dependent receptor binding of SARS-CoV-2 spike proteins
    Authors: Kim M. Bouwman, Ilhan Tomris, Hannah L. Turner, Roosmarijn van der Woude, Tatiana M. Shamorkina, Gerlof P. Bosman et al.
    PLOS Pathogens
  221. SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly
    Authors: Anna Onnis, Emanuele Andreano, Chiara Cassioli, Francesca Finetti, Chiara Della Bella, Oskar Staufer et al.
    Journal of Experimental Medicine
  222. An Immunological Perspective: What Happened to Pregnant Women After Recovering From COVID-19?
    Authors: Sijia Zhao, Ting Xie, Li Shen, Hong Liu, Liling Wang, Xixiang Ma et al.
    Frontiers in Immunology
  223. Development and validation of a rapid and easy-to-perform point-of-care lateral flow immunoassay (LFIA) for the detection of SARS-CoV-2 spike protein
    Authors: Shamim Mohammad, Yuxia Wang, John Cordero, Christopher Watson, Robert Molestina, Sujatha Rashid et al.
    Frontiers in Immunology
  224. A Hybrid Soluble gp130/Spike-Nanobody Fusion Protein Simultaneously Blocks Interleukin-6 trans -Signaling and Cellular Infection with SARS-CoV-2
    Authors: Julia Ettich, Julia Werner, Hendrik T. Weitz, Eva Mueller, Roland Schwarzer, Philipp A. Lang et al.
    Journal of Virology
  225. Attenuation of SARS-CoV-2 infection by losartan in human kidney organoids
    Authors: Waleed Rahmani, Hyunjae Chung, Sarthak Sinha, Maxwell P. Bui-Marinos, Rohit Arora, Arzina Jaffer et al.
    iScience
  226. Uptake of severe acute respiratory syndrome coronavirus 2 spike protein mediated by angiotensin converting enzyme 2 and ganglioside in human cerebrovascular cells
    Authors: Conor McQuaid, Alexander Solorzano, Ian Dickerson, Rashid Deane
    Frontiers in Neuroscience
  227. A Novel Glucocorticoid and Androgen Receptor Modulator Reduces Viral Entry and Innate Immune Inflammatory Responses in the Syrian Hamster Model of SARS-CoV-2 Infection
    Authors: Savannah M. Rocha, Anna C. Fagre, Amanda S. Latham, Jason E. Cummings, Tawfik A. Aboellail, Philip Reigan et al.
    Frontiers in Immunology
  228. SARS-CoV-2 triggers pericyte-mediated cerebral capillary constriction
    Authors: Chanawee Hirunpattarasilp, Greg James, Jaturon Kwanthongdee, Felipe Freitas, Jiandong Huo, Huma Sethi et al.
    Brain
  229. Tissue distribution of ACE2 protein in Syrian golden hamster (Mesocricetus auratus) and its possible implications in SARS-CoV-2 related studies
    Authors: Suresh V, Parida D, Minz A, Senapati S
    Front Pharmacol
  230. Repeated ethanol exposure and withdrawal alters angiotensin-converting enzyme 2 expression in discrete brain regions: Implications for SARS-CoV-2 neuroinvasion
    Authors: Balasubramanian N, James TD, Selvakumar GP et al.
    Alcoholism: Clinical and Experimental Research
  231. Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models
    Authors: Min-Wen Ku, Maryline Bourgine, Pierre Authié, Jodie Lopez, Kirill Nemirov, Fanny Moncoq et al.
    Cell Host & Microbe
  232. A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids
    Authors: Wysocki J, Ye M, Hassler L et al.
    Journal of the American Society of Nephrology : JASN
  233. In well-differentiated primary human bronchial epithelial cells, TGF-beta 1 and TGF-beta 2 induce expression of furin
    Authors: Michael J. O’Sullivan, Jennifer A. Mitchel, Chimwemwe Mwase, Maureen McGill, Phyllis Kanki, Jin-Ah Park
    American Journal of Physiology-Lung Cellular and Molecular Physiology
  234. Genetic Screens Identify Host Factors for SARS-CoV-2 and Common Cold Coronaviruses
    Authors: Wang R, Simoneau CR, Kulsuptrakul J et al.
    Cell
  235. Flagellin From Pseudomonas aeruginosa Modulates SARS-CoV-2 Infectivity in Cystic Fibrosis Airway Epithelial Cells by Increasing TMPRSS2 Expression
    Authors: Manon Ruffin, Jeanne Bigot, Claire Calmel, Julia Mercier, Maëlle Givelet, Justine Oliva et al.
    Frontiers in Immunology
  236. SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent manner
    Authors: Yun-Qi Zhou, Ke Wang, Xue-Yan Wang, Hong-Yong Cui, Yongxiang Zhao, Ping Zhu et al.
    Emerging Microbes & Infections
  237. Platelets mediate inflammatory monocyte activation by SARS-CoV-2 Spike protein
    Authors: Li T, Yang Y, Li Y et al.
    The Journal of clinical investigation
  238. SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
    Authors: J Jansen, KC Reimer, JS Nagai, FS Varghese, GJ Overheul, M de Beer, R Roverts, D Daviran, LAS Fermin, B Willemsen, M Beukenboom, S Djudjaj, S von Stillf, LE van Eijk, M Mastik, M Bulthuis, WD Dunnen, H van Goor, JL Hillebrand, SH Triana, T Alexandrov, MC Timm, BT van den Be, M van den Br, Q Nlandu, J Heijnert, EMJ Bindels, RM Hoogenboez, F Mooren, C Kuppe, P Miesen, K Grünberg, T Ijzermans, EJ Steenberge, J Czogalla, MF Schreuder, N Sommerdijk, A Akiva, P Boor, VG Puelles, J Floege, TB Huber, COVID Moon, RP van Rij, IG Costa, RK Schneider, B Smeets, R Kramann
    Cell Stem Cell, 2021-12-25;29(2):217-231.e8.
  239. Long-Term Modeling of SARS-CoV-2 Infection of In Vitro Cultured Polarized Human Airway Epithelium
    Authors: Siyuan Hao, Kang Ning, Cagla Aksu Kuz, Kai Vorhies, Ziying Yan, Jianming Qiu
    mBio
  240. Impact of COVID‐19 on thrombus composition and response to thrombolysis: Insights from a monocentric cohort population of COVID‐19 patients with acute ischemic stroke
    Authors: Jean‐Philippe Desilles, Mialitiana Solo Nomenjanahary, Arturo Consoli, Véronique Ollivier, Dorothée Faille, Marie‐Charlotte Bourrienne et al.
    Journal of Thrombosis and Haemostasis
  241. Secretory IgA and T cells targeting SARS-CoV-2 spike protein are transferred to the breastmilk upon mRNA vaccination
    Authors: Juliana Gonçalves, A. Margarida Juliano, Nádia Charepe, Marta Alenquer, Diogo Athayde, Filipe Ferreira et al.
    Cell Reports Medicine
  242. Effective vaccination strategy using SARS-CoV-2 spike cocktail against Omicron and other variants of concern
    Authors: Juan Shi, Gang Wang, Jian Zheng, Abhishek K. Verma, Xiaoqing Guan, Moffat M. Malisheni et al.
    npj Vaccines
  243. SARS-CoV-2-triggered mast cell rapid degranulation induces alveolar epithelial inflammation and lung injury
    Authors: Meng-Li Wu, Feng-Liang Liu, Jing Sun, Xin Li, Xiao-Yan He, Hong-Yi Zheng et al.
    Signal Transduction and Targeted Therapy
  244. Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells
    Authors: Elena Garreta, Daniel Moya-Rull, Megan L. Stanifer, Vanessa Monteil, Patricia Prado, Andrés Marco et al.
    STAR Protocols
  245. LRRC15 is an inhibitory receptor blocking SARS-CoV-2 spike-mediated entry in trans
    Authors: Jaewon Song, Ryan D. Chow, Mario Pena-Hernandez, Li Zhang, Skylar A. Loeb, Eui-Young So et al.
    bioRxiv
  246. Increased circulating microparticles contribute to severe infection and adverse outcomes of COVID-19 in patients with diabetes
    Authors: Haoyu Sun, Yong Du, Rinki Kumar, Nicholas Buchkovich, Pingnian He
    American Journal of Physiology-Heart and Circulatory Physiology
  247. Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19
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  249. Dynamics of ADAM17-Mediated Shedding of ACE2 Applied to Pancreatic Islets of Male db/db Mice
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  251. Data, Reagents, Assays and Merits of Proteomics for SARS-CoV-2 Research and Testing
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  252. Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells
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Human/Mouse/Rat/Hamster ACE-2 Antibody
By Anonymous on 10/04/2022
Application: B/N Sample Tested: Embryonic lung Species: Human
Human/Mouse/Rat/Hamster ACE-2 Antibody
By Yuchen Liu on 03/09/2021
Application: Immunocytochemistry/Immunofluorescence Sample Tested: Stimulated Human Bronchial Epithelial Cell Line (BEAS-2B) Species: Human
Immunocytochemistry/Immunofluorescence Human/Mouse/Rat/Hamster ACE-2 Antibody AF933
Human ACE-2 Antibody
By Anonymous on 08/12/2016
Application: WB Sample Tested: Blood mononuclear cells (PBMCs),Human CD34+ Cells Species: Human
Western Blot Human ACE-2 Antibody AF933