Home / LRP-6 / Human LRP-6 APC-conjugated Antibody

Human LRP-6 APC-conjugated Antibody

Catalog #: FAB1505A
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
FAB1505A
Detection of LRP‑6 in MDA‑MB‑231 Human Cell Line by Flow Cytometry.
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Citations (2)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human LRP-6 APC-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human LRP-6 in direct ELISAs. In direct ELISAs, approximately 5% cross-reactivity with recombinant mouse (rm) LRP-6 and no cross-reactivity with recombinant human (rh) LRP-1, -4, -5, rhLRP-6 (intracellular domain), or rhLDL R is observed.
Source
Monoclonal Mouse IgG2A Clone # 255302
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human LRP-6
Ala20-Pro1368
Accession # O75581
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of LRP-6 antibody in MDA-MB-231 Human Cell Line antibody by Flow Cytometry. View Larger

Detection of LRP‑6 in MDA‑MB‑231 Human Cell Line by Flow Cytometry. MDA-MB-231 human breast cancer cell line was stained with Mouse Anti-Human LRP-6 APC-conjugated Monoclonal Antibody (Catalog # FAB1505A, filled histogram) or isotype control antibody (Catalog # IC003A, open histogram). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: LRP-6

LRP-6 (Low-density lipoprotein receptor-related protein 6) is a 200-210 kDa member of the LDLR family of proteins. It is widely expressed, and serves as a coreceptor for both Wnt and parathyroid hormone. In the Wnt system, LRP-6 associates with select Fzd multipass receptors; in the PTH system, LRP-6 complexes with PTH1R. Mature human LRP-6 is a 1594 amino acid (aa) type I transmembrane glycoprotein. It contains a 1351 aa extracellular region (aa 20-1370) plus a 220 aa cytoplasmic domain (aa 1394-1613). The cytoplasmic domain contains two palmitoylation sites, one ubiquitination residue, and multiple phosphorylation motifs.

Long Name
LDL Receptor-related Protein 6
Entrez Gene IDs
4040 (Human); 16974 (Mouse)
Alternate Names
ADCAD2; FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6; LRP6; LRP-6

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Citations for Human LRP-6 APC-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Parkinson's disease-associated receptor GPR37 is an ER chaperone for LRP6
    Authors: BS Berger, SP Acebron, J Herbst, S Koch, C Niehrs
    EMBO Rep, 2017-03-24;0(0):.
  2. Whole Exome/Genome Sequencing Joint Analysis of a Family with Oligogenic Familial Hypercholesterolemia
    Authors: Y Ghaleb, S Elbitar, A Philippi, P El Khoury, Y Azar, M Andrianiri, A Loste, Y Abou-Khali, G Nicolas, M Le Borgne, P Moulin, M Di-Filippo, S Charrière, M Farnier, C Yelnick, V Carreau, J Ferrières, JM Lecerf, A Derksen, G Bernard, MS Gauthier, B Coulombe, D Lütjohann, B Fin, A Boland, R Olaso, JF Deleuze, JP Rabès, C Boileau, M Abifadel, M Varret
    Metabolites, 2022-03-18;12(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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