Human LIGHT/TNFSF14 Antibody
Human LIGHT/TNFSF14 Antibody Summary
Asp74-Val240
Accession # O43557
Applications
Human LIGHT/TNFSF14 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: LIGHT/TNFSF14
Human LIGHT, also known as TNFSF14, is a type II membrane protein that is a member of the TNF superfamily. LIGHT is an acronym which stands for "is homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes". LIGHT has also been called HVEM-L and LT-gamma. LIGHT is a 240 amino acid (aa) protein that contains a 37 aa cytoplasmic domain, a 22 aa transmembrane region, and a 181 aa extracellular domain. Similar to other TNF ligand family members, LIGHT is predicted to assemble as a homotrimer. LIGHT is produced by activated T cells and was first identified by its ability to compete with HSV glycoprotein D for HVEM binding. LIGHT has also been shown to bind to the lymphotoxin beta receptor (LT beta R) and the decoy receptor (DcR3/TR6). LIGHT overexpression in tumor cells induces apoptosis, which can be enhanced by IFN-gamma.
- Mauri, D.N. et al. (1998) Immunity 8:21.
- Zhai, Y. et al. (1998) J. Clin. Invest. 102:1142.
- Harrop, J.A. et al. (1998) J. Biol. Chem. 273:27548.
- Yu, K-Y. et al. (1999) J. Biol. Chem. 274:13733.
Product Datasheets
Citations for Human LIGHT/TNFSF14 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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Licensed human natural killer cells aid dendritic cell maturation via TNFSF14/LIGHT.
Authors: Holmes T, Wilson E, Black E, Benest A, Vaz C, Tan B, Tanavde V, Cook G
Proc Natl Acad Sci U S A, 2014-12-15;111(52):E5688-96.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
4-1BBL induces TNF receptor-associated factor 1-dependent Bim modulation in human T cells and is a critical component in the costimulation-dependent rescue of functionally impaired HIV-specific CD8 T cells.
Authors: Wang C, Wen T, Routy JP, Bernard NF, Sekaly RP, Watts TH
J. Immunol., 2007-12-15;179(12):8252-63.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
LIGHT up-regulated on B lymphocytes and monocytes in rheumatoid arthritis mediates cellular adhesion and metalloproteinase production by synoviocytes.
Authors: Kang YM, Kim SY, Kang JH
Arthritis Rheum., 2007-04-01;56(4):1106-17.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Platelet-derived LIGHT induces inflammatory responses in endothelial cells and monocytes.
Authors: Otterdal K, Smith C, Oie E, Pedersen TM, Yndestad A, Stang E, Endresen K, Solum NO, Aukrust P, Damas JK
Blood, 2006-08-01;108(3):928-35.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P
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Cells were transfected with hLIGHT (IRES GFP) or a negative control. Cells were stained with MAB664 using a 1/500 dilution and binding was detected with an anti-mouse 594 secondary antibody.
