Human Kallikrein 6/Neurosin Antibody Summary
Glu17-Lys244
Accession # Q92876
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Kallikrein 6/Neurosin in Human Breast Cancer Tissue. Kallikrein 6/Neurosin was detected in immersion fixed paraffin-embedded sections of human breast cancer tissue using 15 µg/mL Goat Anti-Human Kallikrein 6/Neurosin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2008) overnight at 4 °C. Tissue was stained with the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Kallikrein 6/Neurosin
Tissue kallikreins are a family of extracellular serine proteases consisting of 15 members (1, 2). The genes of this family aligned in tandem on chromosome 19q13.4 represent the largest contiguous group of proteases within the human genome. Tissue kallikreins have attracted great interest as potential biomarkers for various cancers, including prostate, ovarian, breast, testicular, and lung (2, 3). Human Kallikrein 6 (hKLK6) is a member of tissue kallikrein family observed in breast and brain tissues, colon carcinoma cells, and oligodedrocytes (1-3). Known protein substrates of hKLK6 are myelin basic protein, the precursor of the A beta amyloid peptide, and plasminogen. Its physiological functions may include the participation in demyelination processes as well as in the progression of inflammatory disease of the CNS. The level of hKLK6 is reduced in brain extracts of Alzheimer patients and increased in serum of patients with ovarian cancer.
- Emami, N. and E.P. Diamandis (2007) Clin. Chim. Acta 381:78.
- Borgoño, C.A. and E.P. Diamandis (2004) Nat. Rev. Cancer 4:876.
- Paliouras, M. et al. (2007) Cancer Lett. 249:61.
Product Datasheets
Citations for Human Kallikrein 6/Neurosin Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
8
Citations: Showing 1 - 8
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Hair follicles modulate skin barrier function
Authors: Ford, NC;Benedeck, RE;Mattoon, MT;Peterson, JK;Mesler, AL;Veniaminova, NA;Gardon, DJ;Tsai, SY;Uchida, Y;Wong, SY;
bioRxiv : the preprint server for biology
Species: Mouse
Sample Types: Whole Tissue
Applications: Immunohistochemistry -
Kallikrein 6 protease advances colon tumorigenesis via induction of the high mobility group A2 protein
Authors: Hwudaurw Chen, Earlphia Sells, Ritu Pandey, Edward R. Abril, Chiu-Hsieh Hsu, Robert S. Krouse et al.
Oncotarget
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Expression of Kallikrein-Related Peptidase 6 in Primary Mucosal Malignant Melanoma of the Head and Neck
Authors: Jochen Hess
Head Neck Pathol, 2016-11-14;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Kallikrein-related peptidase 6 regulates epithelial-to-mesenchymal transition and serves as prognostic biomarker for head and neck squamous cell carcinoma patients.
Authors: Schrader C, Kolb M, Zaoui K, Flechtenmacher C, Grabe N, Weber K, Hielscher T, Plinkert P, Hess J
Mol Cancer, 2015-05-20;14(0):107.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Phenotypic characterization of hereditary epithelial ovarian cancer based on a tissue microarray study.
Authors: Munoz-Repeto I, Garcia M, Kamieniak M, Ramon Y Cajal T, Domingo S, Cazorla A, Garcia Donas J, Hernando Polo S, Garcia Sagredo J, Hernandez E, Lacambra C, Saez R, Robles L, Borrego S, Prat J, Palacios J, Benitez J
Histol Histopathol, 2013-01-01;28(1):133-44.
Species: Human
Sample Types: Whole Cells
Applications: IHC-P -
alpha 2 Integrin-Dependent Suppression of Pancreatic Adenocarcinoma Cell Invasion Involves Ectodomain Regulation of Kallikrein-Related Peptidase-5
Authors: Chia-Yao Lee, David Marzan, Grace Lin, Steve Goodison, Steve Silletti
Journal of Oncology
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Novel expression of kallikreins, kallikrein-related peptidases and kinin receptors in human pleural mesothelioma.
Authors: Chee J, Singh J, Naran A, Misso NL, Thompson PJ, Bhoola KD
Biol. Chem., 2007-11-01;388(11):1235-42.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
IL-1 and IL-36 are dominant cytokines in generalized pustular psoriasis.
Authors: Johnston Andrew, Xing Xianying, Wolterink Liza et al.
The Journal of Allergy and Clinical Immunology
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