Human Kallikrein 6/Neurosin Antibody Summary
Leu22-Lys244
Accession # Q92876
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Kallikrein 6/Neurosin
Tissue kallikreins are a family of extracellular serine proteases consisting of 15 members (1, 2). The genes of this family aligned in tandem on chromosome 19q13.4 represent the largest contiguous group of proteases within the human genome. Tissue kallikreins have attracted great interest as potential biomarkers for various cancers, including prostate, ovarian, breast, testicular, and lung (2, 3). Human Kallikrein 6 (KLK6) is a member of tissue kallikrein family observed in breast and brain tissues, colon carcinoma cells, and oligodedrocytes (1‑3). Known protein substrates of KLK6 are myelin basic protein, the precursor of the A beta amyloid peptide, and plasminogen. Its physiological functions may include the participation in demyelination processes as well as in the progression of inflammatory disease of the CNS. The level of KLK6 is reduced in brain extracts of Alzheimer patients and increased in serum of patients with ovarian cancer.
- Emami, N. and E.P. Diamandis (2007) Clin Chim Acta 381:78.
- Borgoño, C.A. and E.P. Diamandis (2004) Nat. Rev. Cancer, 4:876.
- Paliouras, M. et al. (2007) Cancer Lett. 249:61.
Product Datasheets
Citations for Human Kallikrein 6/Neurosin Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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A brain-targeted, modified neurosin (kallikrein-6) reduces alpha-synuclein accumulation in a mouse model of multiple system atrophy.
Authors: Spencer B, Valera E, Rockenstein E, Trejo-Morales M, Adame A, Masliah E
Mol Neurodegener, 2015-09-23;10(1):48.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Low CSF Levels of Both alpha-Synuclein and the alpha-Synuclein Cleaving Enzyme Neurosin in Patients with Synucleinopathy.
Authors: Wennstrom M, Surova Y, Hall S, Nilsson C, Minthon L, Bostrom F, Hansson O, Nielsen H
PLoS ONE, 2013-01-08;8(1):e53250.
Species: Human
Sample Types: CSF
Applications: ELISA Development -
Lentivirus mediated delivery of neurosin promotes clearance of wild-type alpha-synuclein and reduces the pathology in an alpha-synuclein model of LBD.
Authors: Spencer B, Michael S, Shen J, Kosberg K, Rockenstein E, Patrick C, Adame A, Masliah E
Mol Ther, 2012-04-17;21(1):31-41.
Species: Human
Sample Types: Tissue Homogenates
Applications: Western Blot -
Inhibition of transcription factor specificity protein 1 alters the gene expression profile of keratinocytes leading to upregulation of kallikrein-related peptidases and thymic stromal lymphopoietin.
Authors: Bin L, Kim BE, Hall CF
J. Invest. Dermatol., 2011-07-14;131(11):2213-22.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization
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