Human IL-4I1 Antibody

Catalog #: MAB56841 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB56841-100
MAB56841-SP

All IL-4I1 Antibodies

Product Details

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human IL-4I1 Antibody Summary

Species Reactivity

Human

Specificity

Detects human IL-4I1 in direct ELISAs.

Source

Monoclonal Rat IgG_2B Clone # 1006209

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant human IL-4I1
Met1-His567
Accession # Q96RQ9

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Label

Unconjugated

Applications

Recommended Concentration

Sample

ELISA

This antibody functions as an ELISA detection antibody when paired with Rat Anti-Human IL‑4I1 Monoclonal Antibody (Catalog # MAB56842).

This product is intended for assay development on various assay platforms requiring antibody pairs.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-4I1

Interleukin 4 induced protein 1 (IL-4I1), also known as protein FIG-1 and L-amino acid oxidase, is encoded by a B-cell IL-4-inducible gene, FIG1, and is highly expressed in primary metastinal B-cell lymphomas (1-4). It belongs to the flavin monoamine oxidase family, FIG1 subfamily. Enzymological characterization reveals that IL-4I1 has L-amino acid oxidase activity with preference toward aromatic amino acids. Studies have shown that hIL-4I1 inhibited the proliferation of CD3‑stimulated T lymphocytes with a similar effect on CD4(+) and CD8(+) T cells (5). Its inhibitory effect was dependent on enzymatic activity and H₂O₂ production. Its restricted expression to lymphoid tissues indicates that it may play an important function in the immune system (1, 4).

References

Chu, C.C. and W.E. Paul. (1997) Proc. Natl. Acad. Sci. USA 94:2507.
Mason, J.M. et al. (2004) J. Immunol. 173:4561.
Chavan, S.S. et al. (2002) Biochim. Biophys. Acta. 1576:70.
Copie-Bergman, C. et al. (2003) Blood 101:2756.
Boulland, M.L. et al. (2007) Blood 110:220.

Long Name

Interleukin 4-induced Protein-1

Entrez Gene IDs

259307 (Human); 14204 (Mouse); 308575 (Rat); 102115096 (Cynomolgus Monkey)

Alternate Names

Fig-1 protein; FIG1; hFIG1; IL4I1; IL-4I1; IL4-induced protein 1; interleukin 4 induced 1; interleukin four induced 1; LAAO; L-amino-acid oxidase; LAO; UNQ636/PRO1265