Human IL-1 RI APC-conjugated Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of IL‑1 RI in HUVEC Human Cells by Flow Cytometry. HUVEC human umbilical vein endothelial cells were stained with Goat Anti-Human IL-1 RI APC-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB269A, filled histogram) or control antibody (Catalog # IC108A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: IL-1 RI
Two distinct types of receptors that bind the pleiotropic cytokines IL-1 alpha and IL-1 beta have been described. The IL-1 receptor Type I is an 80 kDa transmembrane protein that is expressed predominantly by T cells, fibroblasts, and endothelial cells. IL-1 receptor Type II is a 68 kDa transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Both receptors are members of the immunoglobulin superfamily and show approximately 28% sequence identity in their extracellular domains. The two receptor types do not heterodimerize into a receptor complex.
An IL-1 receptor accessory protein that can heterodimerize with the Type I receptor in the presence of IL-1 alpha or IL-1 beta but not IL-1ra, was identified (1). This Type I receptor complex appears to mediate all the known IL-1 biological responses. The receptor Type II has a short cytoplasmic domain and does not transduce IL-1 signals. In addition to the membrane-bound form of IL-1 RII, a naturally-occurring soluble form of IL-1 RII has been described. It has been suggested that the Type II receptor, either as the membrane-bound or as the soluble form, serves as a decoy for IL-1 and inhibits IL-1 action by blocking the binding of IL-1 to the signaling Type I receptor complex. Recombinant IL-1 soluble receptor Type I is a potent antagonist of IL-1 action.
Product Datasheets
Citations for Human IL-1 RI APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 6
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Inhibition of interleukin-1 signaling enhances elimination of tyrosine kinase inhibitor treated CML stem cells
Blood, 2016-09-12;0(0):.
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Fungal sensing by dectin-1 directs the non-pathogenic polarization of TH17 cells through balanced type I IFN responses in human DCs
Authors: SI Gringhuis, TM Kaptein, EBM Remmerswaa, A Drewniak, BA Wevers, B Theelen, GRAM D'Haens, T Boekhout, TBH Geijtenbee
Nature Immunology, 2022-12-01;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Single-cell sequencing of human white adipose tissue identifies new cell states in health and obesity
Authors: AD Hildreth, F Ma, YY Wong, R Sun, M Pellegrini, TE O'Sullivan
Nature Immunology, 2021-04-27;22(5):639-653.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Differential role of Interleukin-1 and Interleukin-6 in K-Ras-driven pancreatic carcinoma undergoing mesenchymal transition
Authors: I Siddiqui, M Erreni, MA Kamal, C Porta, F Marchesi, S Pesce, F Pasqualini, S Schiarea, C Chiabrando, A Mantovani, P Allavena
Oncoimmunology, 2017-11-01;7(2):e1388485.
Species: Human
Sample Types: Whole Cell
Applications: Flow Cytometry -
Oncogenic Transformation Can Orchestrate Immune Evasion and Inflammation in Human Mesenchymal Stem Cells Independently of Extrinsic Immune-Selective Pressure.
Authors: Miranda A, Funes J, Sanchez N, Limia C, Mesa M, Quezada S, Perez R, de Leon J
Cancer Res, 2015-06-11;75(15):3032-42.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
The IL18RAP region disease polymorphism decreases IL-18RAP/IL-18R1/IL-1R1 expression and signaling through innate receptor-initiated pathways.
Authors: Hedl M, Zheng S, Abraham C
J Immunol, 2014-05-19;192(12):5924-32.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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