Human HM74A/PUMA-G/GPR109A PE-conjugated Antibody Summary
Met1-Pro363
Accession # Q8TDS4
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of HM74A/PUMA-G/GPR109A in Human Blood Neutrophils by Flow Cytometry. Human peripheral blood neutrophils were stained with (A) Rat Anti-Human HM74A/PUMA-G/GPR109A PE-conjugated Monoclonal Antibody (Catalog # FAB2760P) or (B) isotype control antibody (Catalog # IC013P) and Mouse anti-Human Fc gamma RIII (CD16) APC-conjugated Monoclonal Antibody (Catalog # FAB2546A). View our protocol for Staining Membrane-associated Proteins.
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Detection of HM74A/PUMA-G/GPR109A in HEK293 Human Cell Line Transfected with Human HM74A/PUMA-G/GPR109A and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with human HM74A/PUMA-G/GPR109A and eGFP were stained with (A) Rat Anti-Human HM74A/PUMA-G/GPR109A PE-conjugated Monoclonal Antibody (Catalog # FAB2760P) or (B) Isotype Control antibody (Catalog # IC013P). View our protocol for Staining Membrane-associated Proteins.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: HM74A/PUMA-G/GPR109A
HM74A/GPR109A (also known as PUMA-G in mouse) is a 50-55 kDa 7-transmembrane protein member of a small subfamily within the GPCR #1 family. It is expressed on or in a wide variety of cells, including microglia, neutrophils, islet beta -cells, macrophages, adipocytes, retinal pigment epithelium and keratinocytes. Although HM74A is noted for its ability to bind niacin, it natural ligand is beta -hydroxybutyrate. Thus it may naturally act as a negative regulator of fatty acid release by fat, which is converted to ketone bodies by the liver, and which feedback on adipocytes. Full-length human HM74A shares 95% amino acid (aa) sequence identity with human HM74 and 81% aa sequence identity with mouse HM74A.
Product Datasheets
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