Human GR/NR3C1 Antibody (Clone H8031)

Name: Human GR/NR3C1 Antibody (Clone H8031)
Brand: R&D Systems
SKU: PP-H8031-00
Rating: 5 (1 reviews)

Catalog #: PP-H8031-00 1 Review Datasheet / COA / SDS

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PP-H8031-00

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human GR/NR3C1 Antibody (Clone H8031) Summary

Species Reactivity

Human

Source

Monoclonal Mouse IgG2a Clone # H8031

Formulation

A liquid formulation in physiologic saline with 0.1% NaN₃.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Western Blot

Please refer to the PDF datasheet for specifications.

Immunohistochemistry

5-15 µg/mL

Perfusion fixed paraffin-embedded sections of rat pancreas

Immunoprecipitation

Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: GR/NR3C1

Glucocorticoid receptor (GR; NR3C1) is a member of the steroid receptor family. GR are expressed in almost all human tissues and organs. GR bind to its sequences as a homodimer. Two different forms, GR-alpha and GR-beta, differing in their C-terminal parts were isolated. GR-alpha is the classic GR that binds to glucocorticoids and transactivates or transrepresses glucocorticoid-responsive promoters. GR-beta does not bind glucocorticoids.

Long Name

Glucocorticoid Receptor

Entrez Gene IDs

2908 (Human)

Alternate Names

GCR; glucocorticoid receptor; GR; GRGCCR; GRLNuclear receptor subfamily 3 group C member 1; NR3C1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); nuclear receptor subfamily 3, group C, member 1