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Human FGFR3 PE-conjugated Antibody

Catalog #: FAB766P
5 Citations Datasheet / COA / SDS
Clone 136334 was used by HLDA to establish CD designation
Catalog # Availability Size / Price Qty
FAB766P
Detection of FGF R3 in K562 Human Cell Line by Flow Cytometry.
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Citations (5)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human FGFR3 PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects the IIIb and IIIc isoforms of human FGF R3 in direct ELISAs and Western blots. Does not cross-react with any isoforms of recombinant mouse (rm) FGF R3, rmFGF R2, recombinant human (rh) FGF R1, rhFGF R2, or rhFGF R4.
Source
Monoclonal Mouse IgG1 Clone # 136334
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Pool of NS0-derived recombinant human FGF R3 alpha (IIIb) and Sf21-derived FGF R3 alpha (IIIc)
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of FGF R3 antibody in K562 Human Cell Line antibody by Flow Cytometry. View Larger

Detection of FGF R3 in K562 Human Cell Line by Flow Cytometry. K562 human chronic myelogenous leukemia cell line was stained with Mouse Anti-Human FGF R3 PE-conjugated Monoclonal Antibody (Catalog # FAB766P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: FGFR3

Fibroblast Growth Factor Receptor 3 (FGF R3) is a type I transmembrane tyrosine kinase receptor that binds FGF ligands along with heparin or heparin sulfate proteoglycans as co‑factors. A segment of the membrane proximal Ig-like domain can be encoded by two different exons resulting in (IIIb) or (IIIc) isoforms. The IIIb or IIIc isoforms recognize FGF -1, -2, -4, -8b, -8e, -8f, -9, and -17b. FGF R3 plays a role in skeletal, brain, lung, intestine, kidney, and skin development.

Long Name
Fibroblast Growth Factor Receptor 3
Entrez Gene IDs
2261 (Human); 14184 (Mouse)
Alternate Names
CD333; CEK; EC 2.7.10; FGF R3; FGFR3; fibroblast growth factor receptor 3; HSFGFR3EX; JTK4; JTK4thanatophoric dwarfism

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Citations for Human FGFR3 PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Semi-Automated Cell Panning for Efficient Isolation of FGFR3-Targeting Antibody
    Authors: B Min, M Yoo, H Kim, M Cho, DH Nam, Y Yoon
    International Journal of Molecular Sciences, 2021-06-09;22(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. A comprehensive characterisation of large-scale expanded human bone marrow and umbilical cord mesenchymal stem cells
    Authors: C Mennan, J Garcia, S Roberts, C Hulme, K Wright
    Stem Cell Res Ther, 2019-03-18;10(1):99.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. FGF23 is synthesised locally by renal tubules and activates injury-primed fibroblasts
    Authors: ER Smith, SJ Tan, SG Holt, TD Hewitson
    Sci Rep, 2017-06-13;7(1):3345.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. Detection and follow-up of fibroblast growth factor receptor 3 expression on bone marrow and circulating plasma cells by flow cytometry in patients with t(4;14) multiple myeloma.
    Authors: Chandesris MO, Soulier J, Labaume S, Crinquette A, Repellini L, Chemin K, Malphettes M, Fieschi C, Asli B, Uzunhan Y, Fermand JP, Bories JC, Arnulf B
    Br. J. Haematol., 2007-02-01;136(4):609-14.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. Mutational bias in spermatogonia impacts the anatomy of regulatory sites in the human genome
    Authors: Vera B. Kaiser, Lana Talmane, Yatendra Kumar, Fiona Semple, Marie MacLennan, David R. Deciphering Developmental Disorders Study et al.
    Genome Research

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