Human FGFR2 (IIIb) Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
![FGF R2 alpha Inhibition of FGF acidic-dependent Cell Proliferation and Neutralization by Human FGF R2 Antibody. FGF R2 alpha Inhibition of FGF acidic-dependent Cell Proliferation and Neutralization by Human FGF R2 Antibody.](https://resources.rndsystems.com/images/datasheets/antibody/FGF_R2_MAB665_Block_Neutralize_2823.jpg)
FGF R2 alpha Inhibition of FGF acidic-dependent Cell Proliferation and Neutralization by Human FGF R2 Antibody. Recombinant Human FGF R2a (IIIb) Fc Chimera (Catalog # 663-FR) inhibits Recombinant Human FGF acidic (Catalog # 232-FA) induced proliferation in the NR6R‑3T3 mouse fibroblast cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Human FGF acidic (0.3 ng/mL) activity elicited by Recombinant Human FGF R2a (IIIb) Fc Chimera (6 ng/mL) is neutralized (green line) by increasing concentrations of Human FGF R2 (IIIb) Monoclonal Antibody (Catalog # MAB665). The ND50 is typically 2-8 µg/mL in the presence of heparin (10 µg/mL).
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: FGFR2
FGF R2 is a transmembrane tyrosine kinase that functions as a receptor for several FGF family proteins. The extracellular domain includes three ( alpha isoforms) or two ( beta isoforms) Ig-like domains. Alternative exon usage results in IIIb or IIIc isoforms that differ in their membrane proximal Ig-like domain.
Product Datasheets
Citations for Human FGFR2 (IIIb) Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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FGFR-mediated ERK1/2 signaling contributes to mesendoderm and definitive endoderm formation in vitro
Authors: Hwee Hui Lau, Nur Shabrina Amirruddin, Larry Sai Weng Loo, Jun Wei Chan, Elhadi Iich, Vidhya Gomathi Krishnan et al.
iScience
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Effect of tumour-cell-derived or recombinant keratinocyte growth factor (KGF) on proliferation and radioresponse of human epithelial tumour cells (HNSCC) and normal keratinocytes in vitro
Authors: Andrea Hille, Susanne Grüger, Hans Christiansen, Hendrik A. Wolff, Beate Volkmer, Jörg Lehmann et al.
Radiation and Environmental Biophysics
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Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling
Authors: DG Brownfield, AD de Arce, E Ghelfi, A Gillich, TJ Desai, MA Krasnow
Nature Communications, 2022-11-21;13(1):7137.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Translocation of fibroblast growth factor-10 and its receptor into nuclei of human urothelial cells.
Authors: Kosman J, Carmean N, Leaf EM, Dyamenahalli K, Bassuk JA
J. Cell. Biochem., 2007-10-15;102(3):769-85.
Species: Human
Sample Types: Whole Cells
Applications: ICC
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