Human Dopamine D1R/DRD1 Antibody Summary
Met1-Thr446
Accession # P21728
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
![Detection of Dopamine D1 R/DRD1 antibody in HEK293 Human Cell Line Transfected with Human Dopamine D1/DRD1 and eGFP antibody by Flow Cytometry. Detection of Dopamine D1 R/DRD1 antibody in HEK293 Human Cell Line Transfected with Human Dopamine D1/DRD1 and eGFP antibody by Flow Cytometry.](https://aeroglobalimagesuat.blob.core.windows.net/images/datasheets/antibody/Dopamine_D1_R_MAB8276_Flow_Cytometry_15227.jpg)
Detection of Dopamine D1 R/DRD1 in HEK293 Human Cell Line Transfected with Human Dopamine D1/DRD1 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with human Dopamine D1/DRD1 and eGFP was stained with either (A) Mouse Anti-Human Dopamine D1 R/DRD1 Monoclonal Antibody (Catalog # MAB8276) or (B) Mouse IgG2AIsotype Control (Catalog # MAB003) followed by Allophycocyanin-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # F0101B).
![Dopamine D1 R/DRD1 antibody in Human Brain by Immunohistochemistry (IHC-P). Dopamine D1 R/DRD1 antibody in Human Brain by Immunohistochemistry (IHC-P).](https://aeroglobalimagesuat.blob.core.windows.net/images/datasheets/antibody/Dopamine_D1_R_MAB8276_Immunohistochemistry_15175.jpg)
Dopamine D1 R/DRD1 in Human Brain. Dopamine D1 R/DRD1 was detected in immersion fixed paraffin-embedded sections of human brain (caudate nucleus) using Mouse Anti-Human Dopamine D1 R/DRD1 Monoclonal Antibody (Catalog # MAB8276) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific staining was localized to neuronal cytoplasm. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Dopamine D1R/DRD1
Dopamine Receptor D1 (DRD1) is a 50 kDa member of class 1 GPCR superfamily and is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. DRD1 is associated with nicotine dependence, schizophrenia, and systolic blood pressure levels.
Product Datasheets
Citation for Human Dopamine D1R/DRD1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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Dopamine receptors D1 and D2 show prognostic significance and potential therapeutic applications for endometrial cancer patients
Authors: Español, P;Rovira, R;Caruana, P;Luna-Guibourg, R;Soler, C;Teixeira, N;Rodríguez, F;Gallardo, A;Edwards, M;Porta, O;Gámez, M;Sánchez, O;Llurba, E;Corchero, JL;Céspedes, MV;
Gynecologic oncology
Species: Human
Sample Types: Whole Tissue
Applications: Immunohistochemistry
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