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Human CXCR4 PE-conjugated Antibody

Catalog #: FAB173P
14 Citations 1 Review Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
FAB173P-025
FAB173P-100
Detection of CXCR4 in Human Blood Lymphocytes by Flow Cytometry.
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Citations (14)
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Reviews (1)
Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CXCR4 PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Reacts specifically with human and non-human cells expressing human CXCR4 (fusin) as detected by flow cytometry. It will also react with cells expressing feline CXCR4 but not rat CXCR4. This antibody does not cross-react with other chemokine receptors.
Source
Monoclonal Mouse IgG2B Clone # 44717
Purification
Protein A or G purified from ascites
Immunogen
Mouse 3T3 cells transfected with human CXCR4
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of CXCR4 antibody in Human Blood Lymphocytes antibody by Flow Cytometry. View Larger

Detection of CXCR4 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CXCR4 PE-conjugated Monoclonal Antibody (Catalog # FAB173P) and Mouse Anti-Human CD19 APC-conjugated Monoclonal Antibody (FAB4867A) for 15 minutes at 37°C followed by 15 minutes at room temperature. View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: CXCR4

CXCR4 is a G-protein-linked seven transmembrane spanning receptor that binds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factor for T-cell tropic HIV-1 and -2 viral entry into cells.

Long Name
C-X-C Motif Chemokine Receptor 4
Entrez Gene IDs
7852 (Human); 12767 (Mouse); 60628 (Rat); 483900 (Canine); 493676 (Feline)
Alternate Names
CD184; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CXCR4; CXC-R4; CXCR-4; D2S201E; D2S201ESDF-1 receptor; FB22; Fusin; HM89; HM89NPYRL; HSY3RR; LAP3; LAP-3; LCR1; LESTR; LESTRCD184 antigen; Leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; NPY3R; NPY3RWHIM; NPYR; NPYRL; NPYY3R; pCXCR4; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; Stromal cell-derived factor 1 receptor; WHIMS

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Citations for Human CXCR4 PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

14 Citations: Showing 1 - 10
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  1. Reprogramming CD19-Specific T Cells with IL-21 Signaling Can Improve Adoptive Immunotherapy of B-Lineage Malignancies
    Authors: Harjeet Singh, Matthew J. Figliola, Margaret J. Dawson, Helen Huls, Simon Olivares, Kirsten Switzer et al.
    Cancer Research
  2. Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression
    Authors: Katia K. Mattis, Nicole A. J. Krentz, Christoph Metzendorf, Fernando Abaitua, Aliya F. Spigelman, Han Sun et al.
    Diabetologia
  3. Inhibition of CXCR4 by LY2624587, a Fully Humanized Anti-CXCR4 Antibody Induces Apoptosis of Hematologic Malignancies
    Authors: Sheng-Bin Peng, Xiaoyi Zhang, Donald Paul, Lisa M. Kays, Ming Ye, Peter Vaillancourt et al.
    PLOS ONE
  4. Differential B-Cell Receptor Signaling Requirement for Adhesion of Mantle Cell Lymphoma Cells to Stromal Cells
    Authors: L Sadeghi, G Arvidsson, M Merrien, A M Wasik, A Görgens, CIE Smith, B Sander, AP Wright
    Cancers (Basel), 2020-05-02;12(5):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. A human immunodeficiency syndrome caused by mutations in CARMIL2
    Authors: T Schober, T Magg, M Laschinger, M Rohlfs, ND Linhares, J Puchalka, T Weisser, K Fehlner, J Mautner, C Walz, K Hussein, G Jaeger, B Kammer, I Schmid, M Bahia, SD Pena, U Behrends, BH Belohradsk, C Klein, F Hauck
    Nat Commun, 2017-01-23;8(0):14209.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. CXCR4/IgG-expressing plasma cells are associated with human gastrointestinal tissue inflammation.
    Authors: Buckner, Clarisa, Moir, Susan, Kardava, Lela, Ho, Jason, Santich, Brian H, Kim, Leo Jin, Funk, Emily K, Nelson, Amy K, Winckler, Britanny, Chairez, Cheryl L, Theobald-Whiting, Narda L, Anaya-O'Brien, Sandra, Alimchandani, Meghna, Quezado, Martha M, Yao, Michael, Kovacs, Joseph A, Chun, Tae-Wook, Fauci, Anthony, Malech, Harry L, De Ravin, Suk See
    J Allergy Clin Immunol, 2013-12-25;133(6):1676-85.e5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  7. Expression and functional heterogeneity of chemokine receptors CXCR4 and CXCR7 in primary patient-derived glioblastoma cells.
    Authors: Liu, Che, Pham, Kien, Luo, Defang, Reynolds, Brent A, Hothi, Parvinde, Foltz, Gregory, Harrison, Jeffrey
    PLoS ONE, 2013-03-21;8(3):e59750.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  8. Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis.
    Authors: Badr G, Lefevre EA, Mohany M
    PLoS ONE, 2011-09-01;6(9):e23741.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  9. Protein kinase C and NF-kappaB-dependent CD4 downregulation in macrophages induced by T cell-derived soluble factors: consequences for HIV-1 infection.
    Authors: Raposo RA, Trudgian DC, Thomas B, van Wilgenburg B, Cowley SA, James W
    J. Immunol., 2011-06-10;187(2):748-59.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. Human melanoma metastases express functional CXCR4.
    Authors: Scala S, Giuliano P, Ascierto PA, Ierano C, Franco R, Napolitano M, Ottaiano A, Lombardi ML, Luongo M, Simeone E, Castiglia D, Mauro F, De Michele I, Calemma R, Botti G, Caraco C, Nicoletti G, Satriano RA, Castello G
    Clin. Cancer Res., 2006-04-15;12(8):2427-33.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  11. Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry.
    Authors: Hatse S, Princen K, Vermeire K, Gerlach LO, Rosenkilde MM, Schwartz TW, Bridger G, De Clercq E, Schols D
    FEBS Lett., 2003-07-10;546(2):300-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  12. Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS.
    Authors: Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle MT, Pedemonte E, Noonan D, Albini A, Bernardi G, Mancardi GL, Battistini L, Uccelli A
    J. Leukoc. Biol., 2003-05-01;73(5):584-90.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  13. Clonal Th2 cells associated with chronic hypereosinophilia: TARC-induced CCR4 down-regulation in vivo.
    Authors: de Lavareille A, Roufosse F, Schandene L, Stordeur P, Cogan E, Goldman M
    Eur. J. Immunol., 2001-04-01;31(4):1037-46.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  14. Interleukin-6 Production in CD40-Engaged Fibrocytes in Thyroid-Associated Ophthalmopathy: Involvement of Akt and NF-kappa B
    Authors: Erin F. Gillespie, Nupur Raychaudhuri, Konstantinos I. Papageorgiou, Stephen J. Atkins, Ying Lu, Laya K. Charara et al.
    Investigative Opthalmology & Visual Science

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Human CXCR4 PE-conjugated Antibody
By Anonymous on 12/15/2016
Application: Flow Sample Tested: endoderm,induced pluripotent stem cells Species: Human

We use CXCR4 to test the % positive definitive endoderm made from human induced pluripotent stem cells.