Human CXCL7/NAP‑2 Biotinylated Antibody Summary
Ala59-Asp128
Accession # P02775
Applications
Human CXCL7/NAP-2 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CXCL7/NAP-2
Neutrophil Activating Peptide 2 (NAP-2), Connective Tissue Activating Protein III (CTAP‑III) and beta -thrombogulin ( beta ‑TG), are proteolytically processed carboxyl-terminal fragments of platelet basic protein (PBP) which is found in the alpha-granules of human platelets. NAP-2 is a member of the CXC chemokines. Similar to other ELR domain containing CXC chemokines such as IL-8 and the GRO proteins, NAP-2 has been shown to bind CXCR2 and to chemoattract and activate neutrophils. Although CTAP-III, beta -TG and PBP represent amino-terminal extended variants of NAP-2 and possess the same CXC chemokine domains, these proteins do not exhibit NAP-2 activity. It has been shown that the additional amino-terminal residues of CTAP-III masks the critical ELR receptor binding domain that is exposed on NAP-2 and may account for lack of NAP-2 activity.
- Schall, T. (1994) The Cytokine Handbook, 2nd edition, A. Thomson, ed. Academic Press, New York, p. 419.
- Malkowski, M.G. et al. (1997) J. Mol. Biol. 266:367.
Product Datasheets
Citations for Human CXCL7/NAP‑2 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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Identifying platelet-derived factors as amplifiers of B. burgdorferi-induced cytokine production
Authors: Mariska Kerstholt, Freek R van de Schoor, Marije Oosting, Simone J C F M Moorlag, Yang Li, Martin Jaeger et al.
Clinical and Experimental Immunology
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Development of a Glycosaminoglycan Derived, Selectin Targeting Anti-Adhesive Coating to Treat Endothelial Cell Dysfunction
Authors: JR Wodicka, AM Chambers, GS Sangha, CJ Goergen, A Panitch
Pharmaceuticals (Basel), 2017-03-29;10(2):.
Species: Human
Sample Types: Platelet Rich Plasma (PRP)
Applications: ELISA Development (Detection) -
Up-regulation of platelet activation in hemophilia A.
Authors: van Bladel ER, Roest M
Haematologica, 2011-03-21;0(0):.
Species: Human
Sample Types: Plasma
Applications: ELISA Development -
High platelet reactivity is associated with myocardial infarction in premenopausal women: a population-based case-control study.
Authors: Snoep JD, Roest M, Barendrecht AD
J. Thromb. Haemost., 2010-01-30;8(5):906-13.
Species: Human
Sample Types: Plasma
Applications: ELISA Development
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