Human CCR2 PerCP-conjugated Antibody
Human CCR2 PerCP-conjugated Antibody Summary
Met1-Leu360
Accession # NP_001116868
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of CCR2 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD14 APC-conjugated Monoclonal Antibody (Catalog # FAB3832A) and either (A) Mouse Anti-Human CCR2 PerCP-conjugated Monoclonal Antibody (Catalog # FAB151C) or (B) Mouse IgG2BPerCP Isotype Control (Catalog # IC0041C). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: CCR2
CCR2 is a G-protein linked seven transmembrane domain spanning chemokine receptor that preferentially binds monocyte chemoattractant proteins-1 and -3 (MCP-1 and MCP-3). Two isoforms of this receptor (CCR2A and CCR2B) are expressed on cell surfaces as a result of alternate splicing from the same gene. These two CCR2 variants differ only at their intracellular carboxyl terminals, with the CCR2A form possessing 14 additional amino acids. This may provide a mechanism by which cells responding to similar extracellular ligands can activate different intracellular second messengers. Cells that respond to the action of MCP-1 and therefore are likely to express CCR2 receptors, include monocytes, T cells, NK cells, basophils, mast cells and dendritic cells. A recent report suggests that B cells may also express CCR2 receptors. The recognition that a variety of chemokine receptors, including CCR2, can serve as HIV fusion co-factors and as facilitators of T cell recruitment during inflammation makes chemokine receptor monitoring an important exercise in elucidating the HIV infection process and the regulation of inflammatory reactions.
Product Datasheets
Citations for Human CCR2 PerCP-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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Chronic heavy drinking drives distinct transcriptional and epigenetic changes in splenic macrophages
Authors: S Sureshchan, C Stull, BJK Ligh, SB Nguyen, KA Grant, I Messaoudi
EBioMedicine, 2019-04-18;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Tie2 Expressing Monocytes in the Spleen of Patients with Primary Myelofibrosis
Authors: Rita Campanelli
PLoS ONE, 2016-06-09;11(6):e0156990.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine/Chemokine Receptor Complex in Patients with AMD.
Authors: Falk M, Singh A, Faber C, Nissen M, Hviid T, Sorensen T
PLoS ONE, 2014-12-15;9(12):e112473.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Secondary lymphoid organ homing phenotype of human myeloid dendritic cells disrupted by an intracellular oral pathogen.
Authors: Miles, Brodie, Zakhary, Ibrahim, El-Awady, Ahmed, Scisci, Elizabet, Carrion, Julio, O'Neill, John C, Rawlings, Aaron, Stern, J Kobi, Susin, Cristian, Cutler, Christop
Infect Immun, 2013-10-14;82(1):101-11.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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