Human CCR2 Biotinylated Antibody
Human CCR2 Biotinylated Antibody Summary
Met1-Leu360
Accession # NP_001116868
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of CCR2 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD14 Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB3832F) and either (A) Mouse Anti-Human CCR2 Biotinylated Monoclonal Antibody (Catalog # FAB151B) or (B) Mouse IgG2BBiotinylated Isotype Control (Catalog # IC0041B). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: CCR2
CCR2 is a G-protein linked seven transmembrane domain spanning chemokine receptor that preferentially binds Monocyte Chemoattractant Proteins-1 and -3 (MCP-1 and MCP-3). Two isoforms of this receptor (CCR2A and CCR2B) are expressed on cell surfaces as a result of alternate splicing from the same gene. These two CCR2 variants differ only at their intracellular carboxyl terminals, with the CCR2A form possessing 14 additional amino acids. This may provide a mechanism by which cells responding to similar extracellular ligands can activate different intracellular second messengers. Cells that respond to the action of MCP-1 and therefore are likely to express CCR2 receptors, include monocytes, T cells, NK cells, basophils, mast cells and dendritic cells. A recent report suggests that B cells may also express CCR2 receptors. The recognition that a variety of chemokine receptors, including CCR2, can serve as HIV fusion co-factors and as facilitators of T cell recruitment during inflammation makes chemokine receptor monitoring an important exercise in elucidating the HIV infection process and the regulation of inflammatory reactions.
Product Datasheets
Citations for Human CCR2 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 7
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Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells
Authors: F Parween, SP Singh, HH Zhang, N Kathuria, FA Otaizo-Car, A Shamsaddin, PJ Gardina, S Ganesan, J Kabat, HA Lorenzi, TG Myers, JM Farber
bioRxiv : the preprint server for biology, 2023-02-13;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Neutralizing -
C/EBP? drives interactions between human MAIT cells and endothelial cells that are important for extravasation
Authors: CH Lee, HH Zhang, SP Singh, L Koo, J Kabat, H Tsang, TP Singh, JM Farber
Elife, 2018-02-22;7(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
CCR2+CCR5+ T Cells Produce Matrix Metalloproteinase-9 and Osteopontin in the Pathogenesis of Multiple Sclerosis.
Authors: Sato W, Tomita A, Ichikawa D, Lin Y, Kishida H, Miyake S, Ogawa M, Okamoto T, Murata M, Kuroiwa Y, Aranami T, Yamamura T
J Immunol, 2012-10-15;189(10):5057-65.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
CCR2 identifies a stable population of human effector memory CD4+ T cells equipped for rapid recall response.
Authors: Zhang HH, Song K, Rabin RL, Hill BJ, Perfetto SP, Roederer M, Douek DC, Siegel RM, Farber JM
J. Immunol., 2010-10-27;185(11):6646-63.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Monocyte chemoattractant protein-1 (MCP-1)/CCL2 secreted by hepatic myofibroblasts promotes migration and invasion of human hepatoma cells.
Authors: Dagouassat M, Suffee N, Hlawaty H, Haddad O, Charni F, Laguillier C, Vassy R, Martin L, Schischmanoff PO, Gattegno L, Oudar O, Sutton A, Charnaux N
Int. J. Cancer, 2010-03-01;126(5):1095-108.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Down-modulation of CXCR3 surface expression and function in CD8+ T cells from cutaneous T cell lymphoma patients.
Authors: Winter D, Moser J, Kriehuber E, Wiesner C, Knobler R, Trautinger F, Bombosi P, Stingl G, Petzelbauer P, Rot A, Maurer D
J. Immunol., 2007-09-15;179(6):4272-82.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Cutting edge: Human Th17 cells are identified as bearing CCR2+CCR5- phenotype.
Authors: Sato W, Aranami T, Yamamura T
J. Immunol., 2007-06-15;178(12):7525-9.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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