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Human CCR2 APC-conjugated Antibody

Catalog #: FAB151A
12 Citations Datasheet / COA / SDS
Clone 48607 was used by HLDA to establish CD designation
Catalog # Availability Size / Price Qty
FAB151A-025
FAB151A-100
Detection of CCR2 in Human PBMCs by Flow Cytometry.
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Product Details
Citations (12)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CCR2 APC-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human CCR-2 transfectants but not the parental cell line or CCR-5 transfectants.
Source
Monoclonal Mouse IgG2B Clone # 48607
Purification
Protein A or G purified from ascites
Immunogen
NS0 mouse myeloma cell line transfected with human CCR2
Met1-Leu360
Accession # NP_001116868
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of CCR2 antibody in Human PBMCs antibody by Flow Cytometry. View Larger

Detection of CCR2 in Human PBMCs by Flow Cytometry. Human peripheral blood mononuclear cells (PBMCs) were stained with Mouse Anti-Human CD14 PE-conjugated Monoclonal Antibody (Catalog # FAB3832P) and either (A) Mouse Anti-Human CCR2 APC-conjugated Monoclonal Antibody (Catalog # FAB151A) or (B) Mouse IgG2BAllophycocyanin Isotype Control (Catalog # IC0041A). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: CCR2

CCR2 is a G-protein linked seven transmembrane domain spanning chemokine receptor that preferentially binds monocyte chemoattractant proteins-1 and -3 (MCP-1 and MCP-3). Two isoforms of this receptor (CCR2A and CCR2B) are expressed on cell surfaces as a result of alternate splicing from the same gene. These two CCR2 variants differ only at their intracellular carboxyl terminals, with the CCR2A form possessing 14 additional amino acids. This may provide a mechanism by which cells responding to similar extracellular ligands can activate different intracellular second messengers. Cells that respond to the action of MCP-1 and therefore are likely to express CCR2 receptors, include monocytes, T cells, NK cells, basophils, mast cells and dendritic cells. A recent report suggests that B cells may also express CCR2 receptors. The recognition that a variety of chemokine receptors, including CCR2, can serve as HIV fusion co-factors and as facilitators of T cell recruitment during inflammation makes chemokine receptor monitoring an important exercise in elucidating the HIV infection process and the regulation of inflammatory reactions.

Entrez Gene IDs
729230 (Human); 12772 (Mouse); 60463 (Rat)
Alternate Names
C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CC-CKR-2CKR2B; CCR2; CCR-2; CCR2A; CCR2B; CD192 antigen; CD192; chemokine (C-C motif) receptor 2; CKR2; CKR2A; CMKBR2; CMKBR2MGC111760; FLJ78302; MCP-1 receptor; MCP-1-R; MCP-1-RMGC103828; MGC168006; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor

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Citations for Human CCR2 APC-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

12 Citations: Showing 1 - 10
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  1. Monocytes are increased in pregnancy after gestational hypertensive disease
    Authors: JS Castleman, GYH Lip, E Shantsila
    Oncogene, 2022-06-20;12(1):10358.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. Comparison of circulating dendritic cell and monocyte subsets at different stages of atherosclerosis: insights from optical coherence tomography
    Authors: J Zhuang, Y Han, D Xu, G Zhu, S Singh, L Chen, M Zhu, W Chen, Y Xu, X Li
    BMC Cardiovasc Disord, 2017-10-18;17(1):270.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. Detection of Primary T Cell Responses to Drugs and Chemicals in HLA-Typed Volunteers: Implications for the Prediction of Drug Immunogenicity
    Authors: Lee Faulkner
    Toxicol. Sci, 2016-09-16;154(2):416-429.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. The Effect of Post-Resistance Exercise Amino Acids on Plasma MCP-1 and CCR2 Expression
    Authors: Adam J. Wells, Jay R. Hoffman, Adam R. Jajtner, Alyssa N. Varanoske, David D. Church, Adam M. Gonzalez et al.
    Nutrients
  5. Altered Peripheral Blood Monocyte Phenotype and Function in Chronic Liver Disease: Implications for Hepatic Recruitment and Systemic Inflammation
    Authors: Victoria L Gadd
    PLoS ONE, 2016-06-16;11(6):e0157771.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization.
    Authors: Martinez-Martin N, Viejo-Borbolla A, Martin R, Blanco S, Benovic J, Thelen M, Alcami A
    Nat Commun, 2015-01-27;6(0):6163.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  7. CX3CL1/CX3CR1 and CCL2/CCR2 Chemokine/Chemokine Receptor Complex in Patients with AMD.
    Authors: Falk M, Singh A, Faber C, Nissen M, Hviid T, Sorensen T
    PLoS ONE, 2014-12-15;9(12):e112473.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  8. CXCR4 positive and angiogenic monocytes in myocardial infarction.
    Thromb Haemost, 2012-12-06;109(2):255-62.
    Species: Human
    Sample Types: Whole Blood
    Applications: Flow Cytometry
  9. Immunophenotypic characterization of human monocyte subsets: possible implications for cardiovascular disease pathophysiology.
    Authors: Shantsila E, Wrigley B, Tapp L, Apostolakis S, Montoro-Garcia S, Drayson MT, Lip GY
    J. Thromb. Haemost., 2011-05-01;9(5):1056-66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  10. CCR2 identifies a stable population of human effector memory CD4+ T cells equipped for rapid recall response.
    Authors: Zhang HH, Song K, Rabin RL, Hill BJ, Perfetto SP, Roederer M, Douek DC, Siegel RM, Farber JM
    J. Immunol., 2010-10-27;185(11):6646-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  11. Chemokine responsiveness of CD4+ CD25+ regulatory and CD4+ CD25- T cells from atopic and nonatopic donors.
    Authors: Ahern D, Lloyd CM, Robinson DS
    Allergy, 2009-02-07;64(8):1121-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  12. Human cytomegalovirus-encoded interleukin-10 homolog inhibits maturation of dendritic cells and alters their functionality.
    Authors: Chang WL, Baumgarth N, Yu D, Barry PA
    J. Virol., 2004-08-01;78(16):8720-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry

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