Human CCL18/PARC Antibody Summary
Ala21-Ala89
Accession # P55774
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CCL18/PARC
CCL18, also known as alternative macrophage activation-associated CC chemokine (AMAC)-1, macrophage inflammatory protein (MIP)-4, and dendritic cell chemokine (DC-CK1), is a novel CC chemokine that is highly homologous to MIP-1 alpha (61% amino acid (aa) sequence identity). CCL18 cDNA encodes an 89 aa residue precursor protein with a 20 aa putative signal peptide that is cleaved to generate a 69 aa residue mature protein which lacks potential glycosylation sites. In vitro, CCL18 mRNA expression is induced in alternatively activated macrophages by Th2 cytokines such as IL-4, IL-10, and IL-13, and inhibited by IFN‑ gamma. CCL18 mRNA is also expressed by GM-CSF/IL-4-induced monocyte-derived dendritic cells. In vivo, CCL18 is highly expressed in lung and placenta but is not expressed in epidermal Langerhans cells. Recombinant CCL18 has been shown to chemoattract naive T cells but not monocytes or neutrophils.
Product Datasheets
Citations for Human CCL18/PARC Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 7
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IL-4/IL-13 Stimulated Macrophages Enhance Breast Cancer Invasion Via Rho-GTPase Regulation of Synergistic VEGF/CCL-18 Signaling
Authors: Andrew C. Little, Pragathi Pathanjeli, Zhifen Wu, Liwei Bao, Laura E. Goo, Joel A. Yates et al.
Frontiers in Oncology
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CCL18 signaling from tumor-associated macrophages activates fibroblasts to adopt a chemoresistance-inducing phenotype
Authors: W Zeng, L Xiong, W Wu, S Li, J Liu, L Yang, L Lao, P Huang, M Zhang, H Chen, N Miao, Z Lin, Z Liu, X Yang, J Wang, P Wang, E Song, Y Yao, Y Nie, J Chen, D Huang
Oncogene, 2022-11-22;0(0):.
Species: Human, Mouse
Sample Types: In Vivo, Whole Tissue
Applications: IHC, In Vivo -
High CCL18/PARC expression in articular cartilage and synovial tissue of patients with rheumatoid arthritis.
Authors: Momohara S, Okamoto H, Iwamoto T, Mizumura T, Ikari K, Kawaguchi Y, Takeuchi M, Kamatani N, Tomatsu T
J. Rheumatol., 2007-02-01;34(2):266-71.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Induction of prolonged infiltration of T lymphocytes and transient T lymphocyte-dependent collagen deposition in mouse lungs following adenoviral gene transfer of CCL18.
Authors: Luzina IG, Papadimitriou JC, Anderson R, Pochetuhen K, Atamas SP
Arthritis Rheum., 2006-08-01;54(8):2643-55.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Western Blot -
Diesel exhaust exposure favors TH2 cell recruitment in nonatopic subjects by differentially regulating chemokine production.
Authors: Chang Y, Senechal S, de Nadai P, Chenivesse C, Gilet J, Vorng H, Legendre B, Tonnel AB, Wallaert B, Lassalle P, Tsicopoulos A
J. Allergy Clin. Immunol., 2006-06-21;118(2):354-60.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
CCL18 is expressed in atopic dermatitis and mediates skin homing of human memory T cells.
Authors: Gunther C, Bello-Fernandez C, Kopp T, Kund J, Carballido-Perrig N, Hinteregger S, Fassl S, Schwarzler C, Lametschwandtner G, Stingl G, Biedermann T, Carballido JM
J. Immunol., 2005-02-01;174(3):1723-8.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure.
Authors: Pivarcsi A, Gombert M, Dieu-Nosjean MC, Kubitza R, Meller S, Rieker J, Muller A, Da Cunha L, Haahtela A, Sonkoly E, Fridman WH, Alenius H, Kemeny L, Ruzicka T, Zlotnik A
J. Immunol., 2004-11-01;173(9):5810-7.
Species: Human
Sample Types: Whole Tissue
Applications: IHC
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We used this antibody in an in-house ELISA along with mAb (394) and protein (394-PA-010) to detect CCL18 in human serum and plasma. This combination detected CCL18 in human serum and plasma efficiently and generated a good standard curve.
