Human Carnosine Dipeptidase 1/CNDP1 Biotinylated Antibody
Human Carnosine Dipeptidase 1/CNDP1 Biotinylated Antibody Summary
Pro28-His507
Accession # Q96KN2
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Human Carnosine Dipeptidase 1/CNDP1 by ELISA Identification and validation of CNPD1 reduction in CC.Detected protein levels are shown for A. the screen using Sandwich Bead Arrays (SBA) and B. validation by Sandwich Immunoassays (SIA) and expressed as mean intensity fluorescence (MIF). C. There was an excellent correlation between results obtained by SBA and SIA. CNPD1 levels measured by SIA were not influenced by D. age or E. gender. F. Distribution of circulating CNDP1 concentrations determined by SIA in Cohort 2. WS = Weight stable, CC = Cancer cachexia. P- and rho-values are given. Image collected and cropped by CiteAb from the following publication (https://dx.plos.org/10.1371/journal.pone.0123566), licensed under a CC-BY license. Not internally tested by R&D Systems.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Carnosine Dipeptidase 1/CNDP1
The human CNDP1 gene encodes carnosine dipeptidase 1, a member of the M20 family of metalloproteases (1, 2). Also known as X-His dipeptidase, glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1), CNDP1 is a secreted dipeptidase with a narrow specificity for Xaa-His dipeptides including those with Xaa = beta -Ala (carnosine) and Xaa = gamma -aminobutyric acid (homocarnosine), two naturally occurring dipeptides with potential neuroprotective and neurotransmitter fucntions in the brain. In comparison, a closely related protein known as CNDP2, CPGL or CN2, is a cytosolic nonspecific dipeptidase.
Product Datasheets
Citation for Human Carnosine Dipeptidase 1/CNDP1 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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Circulating carnosine dipeptidase 1 associates with weight loss and poor prognosis in gastrointestinal cancer.
Authors: Arner P, Henjes F, Schwenk J, Darmanis S, Dahlman I, Iresjo B, Naredi P, Agustsson T, Lundholm K, Nilsson P, Ryden M
PLoS ONE, 2015-04-21;10(4):e0123566.
Species: Human
Sample Types: Plasma
Applications: ELISA Development (Detection)
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