Home / C1qR1/CD93 / Human C1qR1/CD93 Antibody

Human C1qR1/CD93 Antibody

Catalog #: AF2379
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
AF2379
AF2379-SP
C1qR1/CD93 in U937 Human Cell Line.
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Citations (5)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human C1qR1/CD93 Antibody Summary

Species Reactivity
Human
Specificity
Detects human C1q R1/CD93 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant mouse C1q R1 is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant human C1q R1/CD93
Ala24-Lys580
Accession # Q9NPY3
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human C1q R1/CD93
Flow Cytometry
2.5 µg/106 cells
Human whole blood monocytes
CyTOF-ready
Ready to be labeled using established conjugation methods. No BSA or other carrier proteins that could interfere with conjugation.
 
Immunocytochemistry
5-15 µg/mL
Immersion fixed U937 human histiocytic lymphoma cell line

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunocytochemistry View Larger

C1qR1/CD93 in U937 Human Cell Line. C1qR1/CD93 was detected in immersion fixed U937 human histiocytic lymphoma cell line using Goat Anti-Human C1qR1/CD93 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2379) at 15 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red; NL001) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. Staining was performed using our protocol for Fluorescent ICC Staining of Non-adherent Cells.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: C1qR1/CD93

C1q R1, also known as CD93, C1q R, and C1q RP, is a single chain glycoprotein expressed on cells of myeloid origin, endothelial cells, and hematopoietic progenitor cells. In vitro, this molecule may mediate the enhancement of phagocytosis upon interaction with soluble defense collagens (1, 2).

References
  1. Kim, T.S. et al. (2000) Mol. Immunol. 37:377.
  2. Dean, Y.D. and P. Gasque (2001) Eur. J. Immunol. 31:1370.
Long Name
Complement Component C1q Receptor
Entrez Gene IDs
22918 (Human); 17064 (Mouse); 84398 (Rat)
Alternate Names
AA4 Antigen; C1q R1; C1q receptor 1; C1q Rp; C1q/MBL/SPA receptor; C1qR(P); C1qR1; C1qRp; CD93 antigenC1qR; CD93 molecule; CD93; CDw93C1QR1; Collectin Receptor; Complement component 1 q subcomponent receptor 1; complement component 1, q subcomponent, receptor 1; complement component C1q receptor; dJ737E23.1; ECSM3; Ly68; Matrix-remodeling-associated protein 4; matrix-remodelling associated 4; MXRA4

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Citations for Human C1qR1/CD93 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Significance of Soluble CD93 in Type 2 Diabetes as a Biomarker for Diabetic Nephropathy: Integrated Results from Human and Rodent Studies
    Authors: M Lee, HS Park, MY Choi, HZ Kim, SJ Moon, JY Ha, A Choi, YW Park, JS Park, EC Shin, CW Ahn, S Kang
    J Clin Med, 2020-05-08;9(5):.
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA (detection)
  2. Soluble CD93 is an apoptotic cell opsonin recognized by ?x ?2
    Authors: JWD Blackburn, DHC Lau, EY Liu, J Ellins, AM Vrieze, EN Pawlak, JD Dikeakos, B Heit
    Eur. J. Immunol., 2019-02-07;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  3. Elevated expression of CD93 promotes angiogenesis and tumor growth in nasopharyngeal carcinoma
    Authors: Lili Bao
    Biochem Biophys Res Commun, 2016-05-30;0(0):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  4. Soluble CD93 levels in patients with acute myocardial infarction and its implication on clinical outcome.
    Authors: Youn J, Yu H, Jeon J, Lee H, Jang Y, Park Y, Park Y, Shin E, Ha J
    PLoS ONE, 2014-05-06;9(5):e96538.
    Species: Human
    Sample Types: Serum
    Applications: ELISA Development (Detection)
  5. Plasma CD93 concentration is a potential novel biomarker for coronary artery disease.
    Authors: Malarstig A, Silveira A, Wagsater D, Ohrvik J, Backlund A, Samnegard A, Khademi M, Hellenius ML, Leander K, Olsson T, Uhlen M, de Faire U, Eriksson P, Hamsten A
    J. Intern. Med., 2011-03-21;270(0):229-36.
    Species: Human
    Sample Types: Plasma
    Applications: ELISA Development

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