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Human BMP-2 Antibody

Catalog #: MAB3551
14 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB3551-SP
MAB3551-100
MAB3551-500
Product Details
Citations (14)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human BMP-2 Antibody Summary

Species Reactivity
Human
Specificity
Detects human BMP-2 in ELISAs and Western blots. In Western blots, this antibody shows less than 1% cross-reactivity with recombinant human (rh) BMP‑3, rhBMP-4, rhBMP-5, rhBMP-6, or rhBMP-7.
Source
Monoclonal Mouse IgG2B Clone # 100221
Purification
Protein A or G purified from ascites
Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human BMP-2
Gln283-Arg396
Accession # P12643
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human BMP‑2 (Catalog # 355-BM)

Human BMP-2 Sandwich Immunoassay

Recommended Concentration
Reagent
ELISA Capture (Matched Antibody Pair)
2-8 µg/mL 

Use in combination with:

Detection Reagent: Human BMP‑2 Biotinylated Antibody (Catalog # BAM3552)

Standard: Recombinant Human/Mouse/Rat BMP-2 Protein (Catalog # 355-BM)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: BMP-2

BMP-2 is one of at least 15 structurally and functionally related BMPs, which are members of the transforming growth factor beta (TGF-beta ) superfamily, BMPs were originally identified as protein regulators of cartilage and bone formation. However, they have since been shown to be involved in embryogenesis and morphogenesis of various tissues and organs.

Long Name
Bone Morphogenetic Protein 2
Entrez Gene IDs
650 (Human); 12156 (Mouse); 29373 (Rat)
Alternate Names
BDA2; BMP2; BMP-2; BMP-2A; BMP2ABone morphogenetic protein 2A; bone morphogenetic protein 2; SSFSC

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Citations for Human BMP-2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

14 Citations: Showing 1 - 10
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  1. N-linked glycosylation of the bone morphogenetic protein receptor type 2 (BMPR2) enhances ligand binding
    Authors: Jonathan W. Lowery, Jose M. Amich, Alex Andonian, Vicki Rosen
    Cellular and Molecular Life Sciences
  2. Osteoinduction by combining bone morphogenetic protein (BMP)-2 with a bioactive novel nanocomposite
    Authors: A. Sharma, F. Meyer, M. Hyvonen, S. M. Best, R. E. Cameron, N. Rushton
    Bone & Joint Research
  3. Osteogenic differentiation of human mesenchymal stromal cells and fibroblasts differs depending on tissue origin and replicative senescence
    Authors: V Grotheer, N Skrynecki, L Oezel, J Grassmann, J Windolf, CV Suschek
    Scientific Reports, 2021-06-07;11(1):11968.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. Selective endocytosis of recombinant human BMPs through cell surface heparan sulfate proteoglycans in CHO cells: BMP-2 and BMP-7
    Authors: MG Kim, CL Kim, YS Kim, JW Jang, GM Lee
    Scientific Reports, 2021-02-09;11(1):3378.
    Species: Hamster
    Sample Types: Cell Lysates
    Applications: Western Blot
  5. TNF? drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling
    Authors: LA Hurst, BJ Dunmore, L Long, A Crosby, R Al-Lamki, J Deighton, M Southwood, X Yang, MZ Nikolic, B Herrera, GJ Inman, JR Bradley, AA Rana, PD Upton, NW Morrell
    Nat Commun, 2017-01-13;8(0):14079.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  6. Osteogenic Surface Modification Based on Functionalized Poly-P-Xylylene Coating.
    Authors: Chang C, Yeh S, Lee B, Chen C, Su C, Lin Y, Liu C, Chen H
    PLoS ONE, 2015-09-17;10(9):e0137017.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Bioassay
  7. Regulation of retinal progenitor cell differentiation by bone morphogenetic protein 4 is mediated by the smad/id cascade.
    Authors: Du Y, Xiao Q, Yip HK
    Invest. Ophthalmol. Vis. Sci., 2010-02-03;51(7):3764-73.
    Species: Mouse
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: IHC, Western Blot
  8. Periodontal regeneration using ex vivo autologous stem cells engineered to express the BMP-2 gene: an alternative to alveolaplasty.
    Authors: Chen YL, Chen PK, Jeng LB, Huang CS, Yang LC, Chung HY, Chang SC
    Gene Ther., 2008-08-14;15(22):1469-77.
    Species: Rabbit
    Sample Types: Cell Lysates
    Applications: Western Blot
  9. Chordin-like 1, a bone morphogenetic protein-4 antagonist, is upregulated by hypoxia in human retinal pericytes and plays a role in regulating angiogenesis.
    Authors: Kane R, Godson C, O'Brien C
    Mol. Vis., 2008-06-20;14(0):1138-48.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  10. Targeting of bone morphogenetic protein growth factor complexes to fibrillin.
    Authors: Sengle G, Charbonneau NL, Ono RN, Sasaki T, Alvarez J, Keene DR, Bachinger HP, Sakai LY
    J. Biol. Chem., 2008-03-13;283(20):13874-88.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Western Blot
  11. Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin.
    Authors: Kuns-Hashimoto R, Kuninger D, Nili M, Rotwein P
    Am. J. Physiol., Cell Physiol., 2008-02-20;294(4):C994-C1003.
    Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
    Sample Types: Cell Culture Supernates, Whole Cells
    Applications: ICC, Immunoprecipitation
  12. Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism.
    Authors: Dai J, Keller J, Zhang J, Lu Y, Yao Z, Keller ET
    Cancer Res., 2005-09-15;65(18):8274-85.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  13. Indian hedgehog signaling pathway: expression and regulation in pancreatic cancer.
    Authors: Kayed H, Kleeff J, Keleg S, Guo J, Ketterer K, Berberat P, Giese N, Esposito I, Giese T, Buchler M, Friess H
    Int J Cancer, 2004-07-10;110(5):668-76.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  14. Nanoscale Coatings for Ultralow Dose BMP-2-Driven Regeneration of Critical-Sized Bone Defects
    Authors: Zhe A. Cheng, Andres Alba-Perez, Cristina Gonzalez-Garcia, Hannah Donnelly, Virginia Llopis-Hernandez, Vineetha Jayawarna et al.
    Advanced Science

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