Human BCMA/TNFRSF17 PE-conjugated Antibody Summary
Met1-Ala54
Accession # Q6PE46
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of BCMA/TNFRSF17 in RPMI 8226 Human Cell Line by Flow Cytometry. RPMI 8226 human multiple myeloma cell line was stained with Goat Anti-Human BCMA/TNFRSF17 PE-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB193P, filled histogram) or isotype control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: BCMA/TNFRSF17
BCMA, B cell maturation, is a member of the TNF receptor superfamily. It has been designated TNFRSF17. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development, function and regulation. Human BCMA is a 184 amino acid (aa) protein consisting of a 54 aa extracellular domain, a 23 aa transmembrane domain, and a 107 aa intracellular domain. Mouse and human BCMA share 62% amino acid identity.
- Madry, C. et al. (1998) Int. Immunol. 10:1693.
- Gras, M. et al. (1995) Int. Immunol. 7:1093.
- Kwon, B. et al. (1999) Curr. Opin. Immunol. 11:340.
- Marsters, S. et al. (2000) Curr. Biol. 10:785.
- Thompson, J. et al. (2000) J. Exp. Med. 192:129.
Product Datasheets
Citations for Human BCMA/TNFRSF17 PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 5
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Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells
Authors: M Chapellier, P Peña-Martí, R Ramakrishn, M Eriksson, M Safaee-Tal, C Orsmark-Pi, H Lilljebjör, C Högberg, A Hagström-A, T Fioretos, J Larsson, M Järås
Haematologica, 2019-02-28;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Anti-CD19 CAR T cells with high-dose melphalan and autologous stem cell transplantation for refractory multiple myeloma
Authors: AL Garfall, EA Stadtmauer, WT Hwang, SF Lacey, JJ Melenhorst, M Krevvata, MP Carroll, WH Matsui, Q Wang, MV Dhodapkar, K Dhodapkar, R Das, DT Vogl, BM Weiss, AD Cohen, PA Mangan, EC Ayers, S Nunez-Cruz, I Kulikovska, MM Davis, A Lamontagne, K Dengel, ND Kerr, RM Young, DL Siegel, BL Levine, MC Milone, MV Maus, CH June
JCI Insight, 2018-04-19;3(8):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Clinical relevance of circulating anti-ENA and anti-dsDNA secreting cells from SLE patients and their dependence on STAT-3 activation
Authors: R de la Varg, B Rodríguez-, GA Añez, F Medina Var, JJ Pérez Vene, JA Brieva, C Rodríguez
Eur. J. Immunol., 2017-05-23;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Robust isolation of malignant plasma cells in multiple myeloma.
Authors: Frigyesi I, Adolfsson J, Ali M, Christophersen M, Johnsson E, Turesson I, Gullberg U, Hansson M, Nilsson B
Blood, 2014-01-02;123(9):1336-40.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
APRIL facilitates viral-induced erythroleukemia but is dispensable for T cell immunity and lymphomagenesis.
Authors: Hardenberg G, Fernandez L, Hendriks J, Chebli K, Jacquet C, Sitbon M, Hahne M, Medema JP
J. Leukoc. Biol., 2008-05-15;84(2):380-8.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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