Cyclic Pifithrin-α hydrobromide
Chemical Name: 5,6,7,8-Tetrahydro-2-(4-methylphenyl)-imidazo[2,1-b]benzothiazole hydrobromide
Purity: ≥98%
Biological Activity
Cyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine thymocytes (EC50 = 2.01 μM). Sensitizes p53-deficient tumors to radiotherapy and chemotherapy; increases apoptosis in target cells when used in combination with antimicrotubule agents.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-α.
Barchechath et al.
J.Med.Chem., 2005;48:6409 -
Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies.
Pietrancosta et al.
Bioorg.Med.Chem.Lett., 2005;15:1561 -
Cyclic Pifithrin-α sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis.
Zuco and Zunino
Neoplasia, 2008;10:587
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Citations for Cyclic Pifithrin-α hydrobromide
The citations listed below are publications that use Tocris products. Selected citations for Cyclic Pifithrin-α hydrobromide include:
2 Citations: Showing 1 - 2
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Reversible p53 inhibition prevents cisplatin ototoxicity without blocking chemotherapeutic efficacy.
Authors: Benkafadar Et al.
EMBO Mol Med 2017;9:7
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The p53 co-activator Zac1 neither induces cell cycle arrest nor apoptosis in chicken Lim1 horizontal progenitor cells.
Authors: F Et al.
Cell Death Discov 2015;1:15023
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