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Aliskiren hemifumarate

Catalog #: 5491 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5491/10
5491/50
Aliskiren hemifumarate | CAS No. 173334-58-2 | Additional Synthetic Protease Inhibitors
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Description: Potent renin inhibitor; antihypertensive
Alternative Names: SPP 100

Chemical Name: (αS,γS,δS,ζS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,ζ-bis(1-methylethyl)benzeneoctanamide hemifumarate

Purity: ≥99%

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Biological Activity

Aliskiren hemifumarate is a potent renin inhibitor (IC50 = 0.6 and 80 nM for human and rat respectively). Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nM). Lowers blood pressure in a hypertensive rodent model. Orally active.

Technical Data

M.Wt:
609.83
Formula:
C30H53N3O6.1/2C4H4O4
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
173334-58-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Aliskiren: the first renin inhibitor for clinical treatment.
    Jensen et al.
    Nat.Rev.Drug Discov., 2;7:399
  2. Drug discovery for heart failure: a new era or the end of the pipeline?
    Kaye and Krum
    Nat.Rev.Drug Discov., 2007;6:127
  3. Vitamin D/VDR regulates peripheral energy homeostasis via central renin-angiotensin system
    H Su, N Liu, Y Zhang, J Kong
    Journal of advanced research, 2021;33(0):69-80.

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